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HAND2-AS1 HAND2 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 79804, updated on 23-Mar-2024

Summary

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Official Symbol
HAND2-AS1provided by HGNC
Official Full Name
HAND2 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:48872
See related
Ensembl:ENSG00000237125 MIM:617240; AllianceGenome:HGNC:48872
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UPH; DEIN; NBLA00301
Summary
Predicted to be involved in positive regulation of gene expression. Predicted to act upstream of or within with a positive effect on cardiac right ventricle morphogenesis. Predicted to act upstream of or within transcription elongation from RNA polymerase II promoter. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in endometrium (RPKM 13.8), adrenal (RPKM 11.4) and 8 other tissues See more
Orthologs
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Genomic context

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Location:
4q34.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (173528600..173591255)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (176868392..176930983)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (174449751..174512406)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene stimulator of chondrogenesis 1 Neighboring gene uncharacterized LOC101928409 Neighboring gene uncharacterized LOC124900815 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:174439311-174440510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:174445895-174446436 Neighboring gene uncharacterized LOC124900816 Neighboring gene NANOG hESC enhancer GRCh37_chr4:174457885-174458386 Neighboring gene heart and neural crest derivatives expressed 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:174529467-174530044 Neighboring gene mortality factor 4 (pseudogene) Neighboring gene RAN pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HAND2-AS1 rs2276941 Polymorphism Affecting the Binding of hsa-miR-1275 Is Associated with the Risk of Colorectal Cancer. Gao X, et al. DNA Cell Biol, 2022 Jun. PMID 35575749
  2. HAND2-AS1: A functional cancer-related long non-coding RNA. Gu X, et al. Biomed Pharmacother, 2021 May. PMID 33556872
  3. Role of HAND2-AS1 in human tumors. Da CM, et al. Clin Chim Acta, 2020 Dec. PMID 33096034
  4. LncRNA HAND2-AS1 inhibits proliferation and promotes apoptosis of non-small cell lung cancer cells by inactivating PI3K/Akt pathway. Gao T, et al. Biosci Rep, 2020 Nov 27. PMID 32975291, Free PMC Article
  5. Long noncoding RNA HAND2-AS1 reduced the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis. Bi HQ, et al. Hepatobiliary Pancreat Dis Int, 2020 Dec. PMID 32224127

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of HAND2-FGFR signaling pathway by lncRNA HAND2-AS1 in adenomyosisdagger.
    Title: Activation of HAND2-FGFR signaling pathway by lncRNA HAND2-AS1 in adenomyosis†.
  2. HAND2-AS1 associates with outcomes of acute coronary syndrome and regulates cell viability of vascular endothelial cells.
    Title: HAND2-AS1 associates with outcomes of acute coronary syndrome and regulates cell viability of vascular endothelial cells.
  3. Bladder Cancer Progression Is Suppressed Through the Heart and Neural Crest Derivatives Expressed 2-Antisense RNA 1/microRNA-93-5p/Defective in Cullin Neddylation 1 Domain Containing 3 Axis.
    Title: Bladder Cancer Progression Is Suppressed Through the Heart and Neural Crest Derivatives Expressed 2-Antisense RNA 1/microRNA-93-5p/Defective in Cullin Neddylation 1 Domain Containing 3 Axis.
  4. LncRNA HAND2-AS1 attenuates glioma cell proliferation, invasion and migration by targeting CDK6.
    Title: LncRNA HAND2-AS1 attenuates glioma cell proliferation, invasion and migration by targeting CDK6.
  5. HAND2-AS1 rs2276941 Polymorphism Affecting the Binding of hsa-miR-1275 Is Associated with the Risk of Colorectal Cancer.
    Title: HAND2-AS1 rs2276941 Polymorphism Affecting the Binding of hsa-miR-1275 Is Associated with the Risk of Colorectal Cancer.
  6. Construction and Analysis of lncRNA-Associated ceRNA Network in Atherosclerotic Plaque Formation.
    Title: Construction and Analysis of lncRNA-Associated ceRNA Network in Atherosclerotic Plaque Formation.
  7. Long non-coding RNA HAND2-AS1 delays cervical cancer progression via its regulation on the microRNA-21-5p/TIMP3/VEGFA axis.
    Title: Long non-coding RNA HAND2-AS1 delays cervical cancer progression via its regulation on the microRNA-21-5p/TIMP3/VEGFA axis.
  8. HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates foam cell formation in atherosclerosis.
    Title: HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates foam cell formation in atherosclerosis.
  9. Long noncoding RNA HAND2AS1/miR106a/PTEN axis resensitizes cisplatinresistant ovarian cells to cisplatin treatment.
    Title: Long non‑coding RNA HAND2‑AS1/miR‑106a/PTEN axis re‑sensitizes cisplatin‑resistant ovarian cells to cisplatin treatment.
  10. Long non-coding RNA HAND2-AS1 inhibits gastric cancer progression by suppressing TCEAL7 expression via targeting miR-769-5p.
    Title: Long non-coding RNA HAND2-AS1 inhibits gastric cancer progression by suppressing TCEAL7 expression via targeting miR-769-5p.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • HAND2 antisense RNA 1 (head to head)
  • differentially expressed in neuroblastoma
  • neuroblastoma transcript 301

Clone Names

  • FLJ11539, FLJ41674, FLJ50876

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_003679.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1)
    Source sequence(s)
    AA156933, EF529505
    Related
    ENST00000505621.5

  2. NR_136192.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2)
    Source sequence(s)
    AA156933, BQ882603, EU000853
    Related
    ENST00000507062.6

  3. NR_136193.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3)
    Source sequence(s)
    AA156933, AB075501, AC093849, BQ882603, EU000853

  4. NR_136194.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4)
    Source sequence(s)
    AA156933, AK300846, BQ882603, EU000853

  5. NR_136195.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5)
    Source sequence(s)
    AC093849, AC113154, AK054605, BQ882603
    Related
    ENST00000503474.5

  6. NR_136196.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6)
    Source sequence(s)
    AC079789, BQ882603, DA863153, DB292439

  7. NR_136197.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7)
    Source sequence(s)
    AA156933, DC421261, EU000853

  8. NR_136198.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8)
    Source sequence(s)
    AA156933, BG519698, BQ882603, EU000853

  9. NR_136199.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9)
    Source sequence(s)
    AA156933, AC093849, BQ882603, DC386781, EU000853

  10. NR_136200.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10)
    Source sequence(s)
    AA156933, AB075501, AU253586, BQ882603, EU000853
    Related
    ENST00000502896.5

  11. NR_136201.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11)
    Source sequence(s)
    AA156933, AB075501, AC093849, BQ882603, DA665500, EU000853

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    173528600..173591255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    176868392..176930983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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Chemical Information
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