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DHRS12 dehydrogenase/reductase 12 [ Homo sapiens (human) ]

Gene ID: 79758, updated on 2-Nov-2024

Summary

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Official Symbol
DHRS12provided by HGNC
Official Full Name
dehydrogenase/reductase 12provided by HGNC
Primary source
HGNC:HGNC:25832
See related
Ensembl:ENSG00000102796 MIM:616163; AllianceGenome:HGNC:25832
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR40C1
Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in fat (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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See DHRS12 in Genome Data Viewer
Location:
13q14.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (51754854..51804163, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (50969770..51018859, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52342129..52378299, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7777 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 1 Neighboring gene WD repeat and FYVE domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:52200616-52201123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:52201124-52201630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52201812-52202431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52202432-52203050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:52216947-52217446 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52220347-52220993 Neighboring gene Sharpr-MPRA regulatory region 2859 Neighboring gene uncharacterized LOC124903177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7778 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52371189-52371717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5377 Neighboring gene uncharacterized LOC107984561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7782 Neighboring gene transmembrane protein 272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:52423314-52423814 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:52435707-52436906 Neighboring gene coiled-coil domain containing 70 Neighboring gene CTAGE family member 3, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DHRS12 inhibits the proliferation and metastasis of osteosarcoma via Wnt3a/β-catenin pathway. Xu Z, et al. Future Oncol, 2020 Apr. PMID 32250163
  2. Genetic architecture of asthma in African American patients. Chang X, et al. J Allergy Clin Immunol, 2023 Apr. PMID 36089080, Free PMC Article
  3. Isolation and characterization of proteins associated with histone H3 tails in vivo. Heo K, et al. J Biol Chem, 2007 May 25. PMID 17403666
  4. Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants. Strohm L, et al. Life Sci Alliance, 2022 Nov. PMID 35777956, Free PMC Article
  5. Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Golkowski M, et al. Mol Cell, 2023 Mar 2. PMID 36736316, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic architecture of asthma in African American patients.
    Title: Genetic architecture of asthma in African American patients.
  2. DHRS12 inhibits the proliferation and metastasis of osteosarcoma via Wnt3a/beta-catenin pathway.
    Title: DHRS12 inhibits the proliferation and metastasis of osteosarcoma via Wnt3a/β-catenin pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13639

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 12
Names
dehydrogenase/reductase (SDR family) member 12
short-chain dehydrogenase/reductase family 40C member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031719.3 → NP_001026889.1  dehydrogenase/reductase SDR family member 12 isoform 1

    See identical proteins and their annotated locations for NP_001026889.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL162377, BC009825, DB481446, R60032
    Consensus CDS
    CCDS31976.1
    UniProtKB/Swiss-Prot
    A0PJE2
    Related
    ENSP00000280056.2, ENST00000280056.6
    Conserved Domains (1) summary
    cl25409
    Location:33 → 186
    SDR; Short-chain dehydrogenases/reductases (SDR)

  2. NM_001270424.1 → NP_001257353.1  dehydrogenase/reductase SDR family member 12 isoform 3

    See identical proteins and their annotated locations for NP_001257353.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region and 3' UTR, including the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 3) has distinct N- and C-termini and is longer than isoform 1.
    Source sequence(s)
    AA831151, BC026024, DB481446
    Consensus CDS
    CCDS58292.1
    UniProtKB/Swiss-Prot
    A0PJE2, Q96GB2, Q9H8H1
    Related
    ENSP00000507480.2, ENST00000682342.2
    Conserved Domains (2) summary
    cd09808
    Location:40 → 293
    DHRS-12_like_SDR_c-like; human dehydrogenase/reductase SDR family member (DHRS)-12/FLJ13639-like, classical (c)-like SDRs
    PRK06138
    Location:40 → 298
    PRK06138; short chain dehydrogenase; Provisional

  3. NM_001377533.1 → NP_001364462.1  dehydrogenase/reductase SDR family member 12 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL136525, AL162377
    Consensus CDS
    CCDS91809.1
    UniProtKB/TrEMBL
    A0A8C8L8Z5
    Related
    ENSP00000411565.3, ENST00000444610.8
    Conserved Domains (1) summary
    cl21454
    Location:33 → 244
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. NM_001377929.1 → NP_001364858.1  dehydrogenase/reductase SDR family member 12 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL136525, AL162377
    Conserved Domains (1) summary
    cl21454
    Location:40 → 235
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. NM_001377930.1 → NP_001364859.1  dehydrogenase/reductase SDR family member 12 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL136525, AL162377
    Conserved Domains (1) summary
    cl21454
    Location:103 → 268
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  6. NM_001377931.1 → NP_001364860.1  dehydrogenase/reductase SDR family member 12 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL136525, AL162377
    Conserved Domains (1) summary
    cd09808
    Location:40 → 296
    DHRS-12_like_SDR_c-like; human dehydrogenase/reductase SDR family member (DHRS)-12/FLJ13639-like, classical (c)-like SDRs

  7. NM_001377932.1 → NP_001364861.1  dehydrogenase/reductase SDR family member 12 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL136525, AL162377
    Conserved Domains (1) summary
    cl21454
    Location:1 → 153
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  8. NM_001377933.1 → NP_001364862.1  dehydrogenase/reductase SDR family member 12 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL136525, AL162377
    Conserved Domains (1) summary
    cl21454
    Location:40 → 205
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  9. NM_024705.2 → NP_078981.1  dehydrogenase/reductase SDR family member 12 isoform 2

    See identical proteins and their annotated locations for NP_078981.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA831151, AK023701, DB481446
    Consensus CDS
    CCDS9430.1
    UniProtKB/Swiss-Prot
    A0PJE2
    Related
    ENSP00000218981.1, ENST00000218981.5
    Conserved Domains (1) summary
    cl21454
    Location:33 → 232
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. NR_165330.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136525, AL162377

  2. NR_165332.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136525, AL162377

  3. NR_165333.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136525, AL162377

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    51754854..51804163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430642.1 → XP_047286598.1  dehydrogenase/reductase SDR family member 12 isoform X24

  2. XM_047430638.1 → XP_047286594.1  dehydrogenase/reductase SDR family member 12 isoform X20

  3. XM_047430637.1 → XP_047286593.1  dehydrogenase/reductase SDR family member 12 isoform X19

  4. XM_047430632.1 → XP_047286588.1  dehydrogenase/reductase SDR family member 12 isoform X14

  5. XM_047430634.1 → XP_047286590.1  dehydrogenase/reductase SDR family member 12 isoform X16

  6. XM_047430629.1 → XP_047286585.1  dehydrogenase/reductase SDR family member 12 isoform X11

  7. XM_047430631.1 → XP_047286587.1  dehydrogenase/reductase SDR family member 12 isoform X13

  8. XM_047430628.1 → XP_047286584.1  dehydrogenase/reductase SDR family member 12 isoform X10

  9. XM_047430624.1 → XP_047286580.1  dehydrogenase/reductase SDR family member 12 isoform X6

  10. XM_047430621.1 → XP_047286577.1  dehydrogenase/reductase SDR family member 12 isoform X3

  11. XM_047430645.1 → XP_047286601.1  dehydrogenase/reductase SDR family member 12 isoform X26

  12. XM_047430630.1 → XP_047286586.1  dehydrogenase/reductase SDR family member 12 isoform X12

  13. XM_047430627.1 → XP_047286583.1  dehydrogenase/reductase SDR family member 12 isoform X9

  14. XM_047430626.1 → XP_047286582.1  dehydrogenase/reductase SDR family member 12 isoform X8

  15. XM_047430639.1 → XP_047286595.1  dehydrogenase/reductase SDR family member 12 isoform X21

  16. XM_047430625.1 → XP_047286581.1  dehydrogenase/reductase SDR family member 12 isoform X7

  17. XM_047430623.1 → XP_047286579.1  dehydrogenase/reductase SDR family member 12 isoform X5

  18. XM_047430620.1 → XP_047286576.1  dehydrogenase/reductase SDR family member 12 isoform X2

  19. XM_047430635.1 → XP_047286591.1  dehydrogenase/reductase SDR family member 12 isoform X17

  20. XM_047430622.1 → XP_047286578.1  dehydrogenase/reductase SDR family member 12 isoform X4

  21. XM_047430619.1 → XP_047286575.1  dehydrogenase/reductase SDR family member 12 isoform X1

  22. XM_047430647.1 → XP_047286603.1  dehydrogenase/reductase SDR family member 12 isoform X27

  23. XM_047430646.1 → XP_047286602.1  dehydrogenase/reductase SDR family member 12 isoform X27

  24. XM_047430641.1 → XP_047286597.1  dehydrogenase/reductase SDR family member 12 isoform X23

  25. XM_047430640.1 → XP_047286596.1  dehydrogenase/reductase SDR family member 12 isoform X22

  26. XM_047430636.1 → XP_047286592.1  dehydrogenase/reductase SDR family member 12 isoform X18

  27. XM_047430633.1 → XP_047286589.1  dehydrogenase/reductase SDR family member 12 isoform X15

  28. XM_047430643.1 → XP_047286599.1  dehydrogenase/reductase SDR family member 12 isoform X25

RNA

  1. XR_007063698.1 RNA Sequence

  2. XR_007063697.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    50969770..51018859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375000.1 → XP_054230975.1  dehydrogenase/reductase SDR family member 12 isoform X24

  2. XM_054374996.1 → XP_054230971.1  dehydrogenase/reductase SDR family member 12 isoform X20

  3. XM_054374995.1 → XP_054230970.1  dehydrogenase/reductase SDR family member 12 isoform X19

  4. XM_054374990.1 → XP_054230965.1  dehydrogenase/reductase SDR family member 12 isoform X14

  5. XM_054374992.1 → XP_054230967.1  dehydrogenase/reductase SDR family member 12 isoform X16

  6. XM_054374987.1 → XP_054230962.1  dehydrogenase/reductase SDR family member 12 isoform X11

  7. XM_054374989.1 → XP_054230964.1  dehydrogenase/reductase SDR family member 12 isoform X13

  8. XM_054374986.1 → XP_054230961.1  dehydrogenase/reductase SDR family member 12 isoform X10

  9. XM_054374982.1 → XP_054230957.1  dehydrogenase/reductase SDR family member 12 isoform X6

  10. XM_054374979.1 → XP_054230954.1  dehydrogenase/reductase SDR family member 12 isoform X3

  11. XM_054375002.1 → XP_054230977.1  dehydrogenase/reductase SDR family member 12 isoform X26

  12. XM_054374988.1 → XP_054230963.1  dehydrogenase/reductase SDR family member 12 isoform X12

  13. XM_054374985.1 → XP_054230960.1  dehydrogenase/reductase SDR family member 12 isoform X9

  14. XM_054374984.1 → XP_054230959.1  dehydrogenase/reductase SDR family member 12 isoform X8

  15. XM_054374997.1 → XP_054230972.1  dehydrogenase/reductase SDR family member 12 isoform X21

  16. XM_054374983.1 → XP_054230958.1  dehydrogenase/reductase SDR family member 12 isoform X7

  17. XM_054374981.1 → XP_054230956.1  dehydrogenase/reductase SDR family member 12 isoform X5

  18. XM_054374978.1 → XP_054230953.1  dehydrogenase/reductase SDR family member 12 isoform X2

  19. XM_054374993.1 → XP_054230968.1  dehydrogenase/reductase SDR family member 12 isoform X17

  20. XM_054374980.1 → XP_054230955.1  dehydrogenase/reductase SDR family member 12 isoform X4

  21. XM_054374977.1 → XP_054230952.1  dehydrogenase/reductase SDR family member 12 isoform X1

  22. XM_054375004.1 → XP_054230979.1  dehydrogenase/reductase SDR family member 12 isoform X27

  23. XM_054375003.1 → XP_054230978.1  dehydrogenase/reductase SDR family member 12 isoform X27

  24. XM_054374999.1 → XP_054230974.1  dehydrogenase/reductase SDR family member 12 isoform X23

  25. XM_054374998.1 → XP_054230973.1  dehydrogenase/reductase SDR family member 12 isoform X22

  26. XM_054374994.1 → XP_054230969.1  dehydrogenase/reductase SDR family member 12 isoform X18

  27. XM_054374991.1 → XP_054230966.1  dehydrogenase/reductase SDR family member 12 isoform X15

  28. XM_054375001.1 → XP_054230976.1  dehydrogenase/reductase SDR family member 12 isoform X25

RNA

  1. XR_008488781.1 RNA Sequence

  2. XR_008488780.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0PJE2.2 GenPept UniProtKB/Swiss-Prot:A0PJE2

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