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sirt1 sirtuin 1 [ Danio rerio (zebrafish) ]

Gene ID: 797132, updated on 2-Nov-2024

Summary

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Official Symbol
sirt1provided by ZNC
Official Full Name
sirtuin 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070801-2
See related
Ensembl:ENSDARG00000068064 AllianceGenome:ZFIN:ZDB-GENE-070801-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7148963
Summary
Predicted to enable several functions, including NAD+ binding activity; p53 binding activity; and transcription corepressor activity. Acts upstream of or within several processes, including cell migration involved in sprouting angiogenesis; fin regeneration; and positive regulation of angiogenesis. Predicted to be located in rDNA heterochromatin. Predicted to be active in nuclear inner membrane and nucleoplasm. Is expressed in brain; female organism; liver; male organism; and retina. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See sirt1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (50348975..50366817, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (50035732..50053619, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 137Ba Neighboring gene myopalladin Neighboring gene CDK2 associated cullin domain 1 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 12 Neighboring gene cytochrome c oxidase subunit 5B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cellular Energy Sensor Sirt1 Augments Mapk Signaling to Promote Hypoxia/Reoxygenation-Induced Catch-up Growth in Zebrafish Embryo. Hayasaka O, et al. Zoolog Sci, 2024 Feb. PMID 38587514
  2. Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo. Watchon M, et al. Mol Brain, 2021 Aug 20. PMID 34416891, Free PMC Article
  3. Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1. Bräutigam L, et al. Proc Natl Acad Sci U S A, 2013 Dec 10. PMID 24277839, Free PMC Article
  4. SIRT1 controls endothelial angiogenic functions during vascular growth. Potente M, et al. Genes Dev, 2007 Oct 15. PMID 17938244, Free PMC Article
  5. A behavioral and molecular analysis of ketamine in zebrafish. Zakhary SM, et al. Synapse, 2011 Feb. PMID 20623473, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cellular Energy Sensor Sirt1 Augments Mapk Signaling to Promote Hypoxia/Reoxygenation-Induced Catch-up Growth in Zebrafish Embryo.
    Title: Cellular Energy Sensor Sirt1 Augments Mapk Signaling to Promote Hypoxia/Reoxygenation-Induced Catch-up Growth in Zebrafish Embryo.
  2. Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction.
    Title: Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction.
  3. association of the Sirt1 gene to aging processes and lifespan
    Title: Knockout of longevity gene Sirt1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span.
  4. To our knowledge, our study is the first composite analysis of sirtuins in adult zebrafish retina and provides sufficient evidence that resveratrol, as an activator of SIRT1, protects NMDA-induced zebrafish retinal damage by potentially mediating mitochondrial sirtuins and OPA1 genes.
    Title: Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina.
  5. Formation of a functional vascular system requires glutaredoxin 2-dependent reversible S-glutathionylation of the NAD+-dependent protein deacetylase sirtuin 1.
    Title: Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of gliogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of gliogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1
Names
sirtuin (silent mating type information regulation 2 homolog) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    50348975..50366817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001334404.7 → XP_001334440.4  NAD-dependent protein deacetylase sirtuin-1

    UniProtKB/TrEMBL
    A0A8M1Q1C3, E7F8W3
    Related
    ENSDARP00000088981.3, ENSDART00000098209.5
    Conserved Domains (1) summary
    cd01408
    Location:190 → 425
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
Nucleotide Protein Strain
Heading Accession and Version

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