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ZNF329 zinc finger protein 329 [ Homo sapiens (human) ]

Gene ID: 79673, updated on 14-Nov-2024

Summary

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Official Symbol
ZNF329provided by HGNC
Official Full Name
zinc finger protein 329provided by HGNC
Primary source
HGNC:HGNC:14209
See related
Ensembl:ENSG00000181894 AllianceGenome:HGNC:14209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 4.3), thyroid (RPKM 3.5) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF329 in Genome Data Viewer
Location:
19q13.43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58126248..58155104, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61222728..61251579, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58637615..58662156, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 526, pseudogene Neighboring gene zinc finger and SCAN domain containing 18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15178 Neighboring gene uncharacterized LOC124904784 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58694039-58694752 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58694753-58695464 Neighboring gene zinc finger protein 274

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Reconstructing directed gene regulatory network by only gene expression data. Zhang L, et al. BMC Genomics, 2016 Aug 18. PMID 27556418, Free PMC Article
  2. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265
  3. USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer. Ren Y, et al. Cancer Res, 2023 Apr 4. PMID 36607699
  4. Functional proteomics mapping of a human signaling pathway. Colland F, et al. Genome Res, 2004 Jul. PMID 15231748, Free PMC Article
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12586

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 329

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024620.4 → NP_078896.3  zinc finger protein 329

    See identical proteins and their annotated locations for NP_078896.3

    Status: VALIDATED

    Source sequence(s)
    AC008751, AK095349, BC047501
    Consensus CDS
    CCDS12972.1
    UniProtKB/Swiss-Prot
    B3KR32, Q86UD4, Q9H9R7
    Related
    ENSP00000470008.1, ENST00000598312.6
    Conserved Domains (5) summary
    COG5048
    Location:177 → 539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:233 → 253
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:203 → 225
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:457 → 524
    DUF45; Protein of unknown function DUF45

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58126248..58155104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723384.4 → XP_006723447.1  zinc finger protein 329 isoform X2

    See identical proteins and their annotated locations for XP_006723447.1

    UniProtKB/Swiss-Prot
    B3KR32, Q86UD4, Q9H9R7
    Conserved Domains (5) summary
    COG5048
    Location:177 → 539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:233 → 253
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:203 → 225
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:457 → 524
    DUF45; Protein of unknown function DUF45

  2. XM_011527313.3 → XP_011525615.1  zinc finger protein 329 isoform X1

    See identical proteins and their annotated locations for XP_011525615.1

    Conserved Domains (5) summary
    COG5048
    Location:200 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256 → 276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226 → 248
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:380 → 405
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:480 → 547
    DUF45; Protein of unknown function DUF45

  3. XM_011527310.3 → XP_011525612.1  zinc finger protein 329 isoform X1

    See identical proteins and their annotated locations for XP_011525612.1

    Conserved Domains (5) summary
    COG5048
    Location:200 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256 → 276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226 → 248
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:380 → 405
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:480 → 547
    DUF45; Protein of unknown function DUF45

  4. XM_006723383.4 → XP_006723446.1  zinc finger protein 329 isoform X2

    See identical proteins and their annotated locations for XP_006723446.1

    UniProtKB/Swiss-Prot
    B3KR32, Q86UD4, Q9H9R7
    Conserved Domains (5) summary
    COG5048
    Location:177 → 539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:233 → 253
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:203 → 225
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:457 → 524
    DUF45; Protein of unknown function DUF45

  5. XM_011527311.3 → XP_011525613.1  zinc finger protein 329 isoform X1

    See identical proteins and their annotated locations for XP_011525613.1

    Conserved Domains (5) summary
    COG5048
    Location:200 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256 → 276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226 → 248
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:380 → 405
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:480 → 547
    DUF45; Protein of unknown function DUF45

  6. XM_047439443.1 → XP_047295399.1  zinc finger protein 329 isoform X1

  7. XM_011527314.3 → XP_011525616.1  zinc finger protein 329 isoform X1

    See identical proteins and their annotated locations for XP_011525616.1

    Conserved Domains (5) summary
    COG5048
    Location:200 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256 → 276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226 → 248
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:380 → 405
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:480 → 547
    DUF45; Protein of unknown function DUF45

  8. XM_011527316.3 → XP_011525618.1  zinc finger protein 329 isoform X2

    See identical proteins and their annotated locations for XP_011525618.1

    UniProtKB/Swiss-Prot
    B3KR32, Q86UD4, Q9H9R7
    Conserved Domains (5) summary
    COG5048
    Location:177 → 539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:233 → 253
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:203 → 225
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:457 → 524
    DUF45; Protein of unknown function DUF45

  9. XM_006723381.3 → XP_006723444.1  zinc finger protein 329 isoform X2

    See identical proteins and their annotated locations for XP_006723444.1

    UniProtKB/Swiss-Prot
    B3KR32, Q86UD4, Q9H9R7
    Related
    ENSP00000350773.4, ENST00000358067.5
    Conserved Domains (5) summary
    COG5048
    Location:177 → 539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:233 → 253
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:203 → 225
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:457 → 524
    DUF45; Protein of unknown function DUF45

  10. XM_011527312.3 → XP_011525614.1  zinc finger protein 329 isoform X1

    See identical proteins and their annotated locations for XP_011525614.1

    Conserved Domains (5) summary
    COG5048
    Location:200 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:256 → 276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226 → 248
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:380 → 405
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:480 → 547
    DUF45; Protein of unknown function DUF45

  11. XM_006723382.4 → XP_006723445.1  zinc finger protein 329 isoform X2

    See identical proteins and their annotated locations for XP_006723445.1

    UniProtKB/Swiss-Prot
    B3KR32, Q86UD4, Q9H9R7
    Conserved Domains (5) summary
    COG5048
    Location:177 → 539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:233 → 253
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:203 → 225
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain
    cl19237
    Location:457 → 524
    DUF45; Protein of unknown function DUF45

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61222728..61251579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322161.1 → XP_054178136.1  zinc finger protein 329 isoform X1

  2. XM_054322168.1 → XP_054178143.1  zinc finger protein 329 isoform X2

    UniProtKB/Swiss-Prot
    B3KR32, Q86UD4, Q9H9R7

  3. XM_054322162.1 → XP_054178137.1  zinc finger protein 329 isoform X1

  4. XM_054322167.1 → XP_054178142.1  zinc finger protein 329 isoform X2

    UniProtKB/Swiss-Prot
    B3KR32, Q86UD4, Q9H9R7

  5. XM_054322160.1 → XP_054178135.1  zinc finger protein 329 isoform X1

  6. XM_054322158.1 → XP_054178133.1  zinc finger protein 329 isoform X1

  7. XM_054322163.1 → XP_054178138.1  zinc finger protein 329 isoform X1

  8. XM_054322159.1 → XP_054178134.1  zinc finger protein 329 isoform X1

  9. XM_054322164.1 → XP_054178139.1  zinc finger protein 329 isoform X2

    UniProtKB/Swiss-Prot
    B3KR32, Q86UD4, Q9H9R7

  10. XM_054322165.1 → XP_054178140.1  zinc finger protein 329 isoform X2

    UniProtKB/Swiss-Prot
    B3KR32, Q86UD4, Q9H9R7

  11. XM_054322166.1 → XP_054178141.1  zinc finger protein 329 isoform X2

    UniProtKB/Swiss-Prot
    B3KR32, Q86UD4, Q9H9R7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UD4.2 GenPept UniProtKB/Swiss-Prot:Q86UD4

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