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cxcr2 chemokine (C-X-C motif) receptor 2 [ Danio rerio (zebrafish) ]

Gene ID: 796724, updated on 2-Nov-2024

Summary

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Official Symbol
cxcr2provided by ZNC
Official Full Name
chemokine (C-X-C motif) receptor 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-100414-1
See related
Ensembl:ENSDARG00000054975 AllianceGenome:ZFIN:ZDB-GENE-100414-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CXCR1bb; si:ch73-54b5.1
Summary
Enables granulocyte colony-stimulating factor binding activity. Acts upstream of or within several processes, including leukocyte migration involved in inflammatory response; neutrophil activation; and neutrophil migration. Predicted to be located in membrane. Is expressed in several structures, including digestive system; head; heart; intermediate cell mass of mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; WHIM syndrome 2; end stage renal disease; pyelonephritis (multiple); and urinary tract infection. Orthologous to several human genes including CXCR2 (C-X-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See cxcr2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (48105382..48111050)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (48410767..48411865)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene C-X-C chemokine receptor type 1 Neighboring gene uncharacterized LOC137496503 Neighboring gene methyltransferase 5, N6-adenosine Neighboring gene kelch-like family member 23 Neighboring gene transfer RNA methionine (anticodon CAU)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Live Imaging of Chemokine Receptors in Zebrafish Neutrophils During Wound Responses. Georgantzoglou A, et al. J Vis Exp, 2020 Dec 4. PMID 33346191
  2. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Powell D, et al. Cell Rep, 2017 May 23. PMID 28538177, Free PMC Article
  3. The inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish. Torraca V, et al. Dev Comp Immunol, 2017 Feb. PMID 27815178
  4. Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish. Coombs C, et al. Nat Commun, 2019 Nov 14. PMID 31727891, Free PMC Article
  5. Cxcl8b and Cxcr2 Regulate Neutrophil Migration through Bloodstream in Zebrafish. Zuñiga-Traslaviña C, et al. J Immunol Res, 2017. PMID 28642884, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. differential ligand-induced trafficking of chemokine receptors such as Cxcr1 and Cxcr2 orchestrates the state of neutrophil congregation at sites of tissue damage.
    Title: Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish.
  2. results obtained indicate that Cxcl8b and Cxcr2 are key regulators of neutrophil migration by the bloodstream in zebrafish
    Title: Cxcl8b and Cxcr2 Regulate Neutrophil Migration through Bloodstream in Zebrafish.
  3. this study shows that the inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish
    Title: The inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables C-X-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables granulocyte colony-stimulating factor binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leukocyte migration involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C-X-C chemokine receptor type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    48105382..48111050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223678.1 → XP_068079779.1  C-X-C chemokine receptor type 1

    Related
    ENSDARP00000071727.4, ENSDART00000077260.5
Nucleotide Protein Strain
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