epha3 eph receptor A3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: epha3provided by ZNC
Official Full Name: eph receptor A3provided by ZNC
Primary source: ZFIN:ZDB-GENE-010724-10
See related: Ensembl:ENSDARG00000039373 AllianceGenome:ZFIN:ZDB-GENE-010724-10
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: epha3l; si:dkey-114e9.1; si:ch211-176k6.1
Summary: Predicted to enable transmembrane-ephrin receptor activity. Acts upstream of or within mesoderm migration involved in gastrulation and somitogenesis. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in optic cup. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human EPHA3 (EPH receptor A3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (16445114..16622467)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (16437398..16615414)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ephrin type-A receptor 3

Names: eph receptor A3, like

NP_001352101.1

EC 2.7.10.1

XP_009302851.1

EC 2.7.10.1

XP_009302852.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365172.1 → NP_001352101.1 ephrin type-A receptor 3 precursor

Status: VALIDATED

Source sequence(s)

CABZ01027126, CR556723, CT025925

UniProtKB/TrEMBL

A0A8M3AVX1

Conserved Domains (5) summary

cd09544
Location:910 → 972

SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors

cd10481
Location:28 → 199

EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3

cd00063
Location:435 → 526

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:614 → 880

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:545 → 614

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

16445114..16622467

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009304576.4 → XP_009302851.1 ephrin type-A receptor 3 isoform X1

UniProtKB/TrEMBL

A0A8M3B5I9

Conserved Domains (6) summary

cd09544
Location:909 → 971

SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors

cd10481
Location:28 → 199

EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3

cd00063
Location:435 → 525

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:613 → 879

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam07714
Location:618 → 875

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:544 → 613

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
XM_009304577.4 → XP_009302852.1 ephrin type-A receptor 3 isoform X2

UniProtKB/TrEMBL

A0A8M3B2K7

Related

ENSDARP00000021706.12, ENSDART00000006787.12

Conserved Domains (6) summary

cd10481
Location:28 → 199

EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3

cd00063
Location:435 → 526

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:614 → 880

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam07714
Location:619 → 876

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:545 → 614

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl15755
Location:910 → 947

SAM_superfamily; SAM (Sterile alpha motif )