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TTC13 tetratricopeptide repeat domain 13 [ Homo sapiens (human) ]

Gene ID: 79573, updated on 3-Nov-2024

Summary

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Official Symbol
TTC13provided by HGNC
Official Full Name
tetratricopeptide repeat domain 13provided by HGNC
Primary source
HGNC:HGNC:26204
See related
Ensembl:ENSG00000143643 AllianceGenome:HGNC:26204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in lymph node (RPKM 8.0), spleen (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

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See TTC13 in Genome Data Viewer
Location:
1q42.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (230906243..230978861, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (230286691..230359339, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (231041989..231114607, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373167 Neighboring gene uncharacterized LOC124904844 Neighboring gene RNA, 7SL, cytoplasmic 837, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231037919-231038420 Neighboring gene MPRA-validated peak762 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2721 Neighboring gene ARV1 homolog, fatty acid homeostasis modulator Neighboring gene microRNA 1182 Neighboring gene family with sequence similarity 89 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TTC13 expression and STAT3 activation may form a positive feedback loop to promote ccRCC progression.
    Title: TTC13 expression and STAT3 activation may form a positive feedback loop to promote ccRCC progression.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TTC13 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22584

General protein information

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Preferred Names
tetratricopeptide repeat protein 13
Names
TPR repeat protein 13
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122835.3 → NP_001116307.2  tetratricopeptide repeat protein 13 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the middle portion of the coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AK075386, AK075561, BC047662, DA741498, EL946523
    Consensus CDS
    CCDS44332.2
    UniProtKB/TrEMBL
    Q69YR0
    Related
    ENSP00000355622.4, ENST00000366662.8
    Conserved Domains (4) summary
    sd00006
    Location:196 → 224
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:264 → 297
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:229 → 294
    TPR_11; TPR repeat
    pfam13424
    Location:149 → 228
    TPR_12; Tetratricopeptide repeat

  2. NM_001376507.1 → NP_001363436.1  tetratricopeptide repeat protein 13 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
    UniProtKB/TrEMBL
    Q69YR0
    Conserved Domains (2) summary
    TIGR02917
    Location:119 → 387
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:218 → 246
    TPR; TPR repeat [structural motif]

  3. NM_001376508.1 → NP_001363437.1  tetratricopeptide repeat protein 13 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
    UniProtKB/TrEMBL
    Q69YR0
    Conserved Domains (2) summary
    COG0457
    Location:114 → 275
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:179 → 204
    TPR; TPR repeat [structural motif]

  4. NM_001376509.1 → NP_001363438.1  tetratricopeptide repeat protein 13 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
    UniProtKB/TrEMBL
    Q69YR0
    Conserved Domains (2) summary
    TIGR02917
    Location:126 → 310
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:188 → 216
    TPR; TPR repeat [structural motif]

  5. NM_001376510.1 → NP_001363439.1  tetratricopeptide repeat protein 13 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
    UniProtKB/TrEMBL
    Q69YR0
    Conserved Domains (2) summary
    TIGR02917
    Location:119 → 418
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:249 → 277
    TPR; TPR repeat [structural motif]

  6. NM_001376511.1 → NP_001363440.1  tetratricopeptide repeat protein 13 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
    UniProtKB/TrEMBL
    Q69YR0
    Conserved Domains (2) summary
    COG0457
    Location:145 → 329
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:196 → 224
    TPR; TPR repeat [structural motif]

  7. NM_001376512.1 → NP_001363441.1  tetratricopeptide repeat protein 13 isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
    UniProtKB/TrEMBL
    Q69YR0
    Conserved Domains (2) summary
    COG0457
    Location:139 → 306
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:241 → 269
    TPR; TPR repeat [structural motif]

  8. NM_001376513.1 → NP_001363442.1  tetratricopeptide repeat protein 13 isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
    UniProtKB/TrEMBL
    Q69YR0
    Conserved Domains (2) summary
    TIGR02917
    Location:119 → 387
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:218 → 246
    TPR; TPR repeat [structural motif]

  9. NM_001376514.1 → NP_001363443.1  tetratricopeptide repeat protein 13 isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AL844165, FO393421
    UniProtKB/TrEMBL
    Q69YR0
    Conserved Domains (2) summary
    TIGR02917
    Location:126 → 310
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:188 → 216
    TPR; TPR repeat [structural motif]

  10. NM_024525.5 → NP_078801.3  tetratricopeptide repeat protein 13 isoform a precursor

    See identical proteins and their annotated locations for NP_078801.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK074365, AK075386, AK075561, DA468037, DA741498, EL946523
    Consensus CDS
    CCDS1588.1
    UniProtKB/Swiss-Prot
    B1AQI1, B1AQI2, Q8IVP8, Q8NBI0, Q8NBP0, Q8ND20
    UniProtKB/TrEMBL
    A0A384NPL4, Q69YR0
    Related
    ENSP00000355621.4, ENST00000366661.9
    Conserved Domains (2) summary
    sd00006
    Location:249 → 277
    TPR; TPR repeat [structural motif]
    cl26002
    Location:119 → 418
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    230906243..230978861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711814.3 → XP_006711877.1  tetratricopeptide repeat protein 13 isoform X2

    UniProtKB/TrEMBL
    Q69YR0
    Conserved Domains (4) summary
    sd00006
    Location:188 → 216
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:188 → 221
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:189 → 253
    TPR_11; TPR repeat
    pfam13424
    Location:149 → 215
    TPR_12; Tetratricopeptide repeat

  2. XM_047430306.1 → XP_047286262.1  tetratricopeptide repeat protein 13 isoform X3

  3. XM_005273264.3 → XP_005273321.1  tetratricopeptide repeat protein 13 isoform X1

    UniProtKB/TrEMBL
    Q69YR0
    Conserved Domains (3) summary
    sd00006
    Location:241 → 269
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:241 → 274
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:242 → 306
    TPR_11; TPR repeat

  4. XM_047430313.1 → XP_047286269.1  tetratricopeptide repeat protein 13 isoform X4

  5. XM_011544276.3 → XP_011542578.1  tetratricopeptide repeat protein 13 isoform X5

    Conserved Domains (3) summary
    sd00006
    Location:19 → 49
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:20 → 53
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:21 → 85
    TPR_11; TPR repeat

  6. XM_047430332.1 → XP_047286288.1  tetratricopeptide repeat protein 13 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    230286691..230359339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338715.1 → XP_054194690.1  tetratricopeptide repeat protein 13 isoform X14

  2. XM_054338714.1 → XP_054194689.1  tetratricopeptide repeat protein 13 isoform X13

  3. XM_054338712.1 → XP_054194687.1  tetratricopeptide repeat protein 13 isoform X2

  4. XM_054338710.1 → XP_054194685.1  tetratricopeptide repeat protein 13 isoform X12

  5. XM_054338709.1 → XP_054194684.1  tetratricopeptide repeat protein 13 isoform X11

  6. XM_054338713.1 → XP_054194688.1  tetratricopeptide repeat protein 13 isoform X3

  7. XM_054338708.1 → XP_054194683.1  tetratricopeptide repeat protein 13 isoform X10

  8. XM_054338707.1 → XP_054194682.1  tetratricopeptide repeat protein 13 isoform X9

  9. XM_054338711.1 → XP_054194686.1  tetratricopeptide repeat protein 13 isoform X1

  10. XM_054338706.1 → XP_054194681.1  tetratricopeptide repeat protein 13 isoform X8

  11. XM_054338705.1 → XP_054194680.1  tetratricopeptide repeat protein 13 isoform X7

  12. XM_054338716.1 → XP_054194691.1  tetratricopeptide repeat protein 13 isoform X4

  13. XM_054338717.1 → XP_054194692.1  tetratricopeptide repeat protein 13 isoform X5

  14. XM_054338718.1 → XP_054194693.1  tetratricopeptide repeat protein 13 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NBP0.3 GenPept UniProtKB/Swiss-Prot:Q8NBP0

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