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Igfals insulin-like growth factor binding protein, acid labile subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 79438, updated on 2-Nov-2024

Summary

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Official Symbol
Igfalsprovided by RGD
Official Full Name
insulin-like growth factor binding protein, acid labile subunitprovided by RGD
Primary source
RGD:68429
See related
EnsemblRapid:ENSRNOG00000015061 AllianceGenome:RGD:68429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Als
Summary
Enables insulin-like growth factor binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; and cellular response to growth hormone stimulus. Part of insulin-like growth factor ternary complex. Orthologous to human IGFALS (insulin like growth factor binding protein acid labile subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 342.9) and Kidney (RPKM 47.2) See more
Orthologs
human mouse all
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Genomic context

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See Igfals in Genome Data Viewer
Location:
10q12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14397076..14408439)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13897468..13903920)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14240308..14243554)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene transfer RNA proline (anticodon AGG) 67 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene NUBP iron-sulfur cluster assembly factor 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Purification and characterization of the acid-labile subunit of rat serum insulin-like growth factor binding protein complex. Baxter RC, et al. Endocrinology, 1994 Feb. PMID 7507839
  2. Regulation of the acid-labile subunit of the insulin-like growth factor complex in cultured rat hepatocytes. Dai J, et al. Endocrinology, 1994 Sep. PMID 8070348
  3. Cloning and characterization of the rat gene for the acid-labile subunit of the insulin-like growth factor binding protein complex. Delhanty PJ, et al. J Mol Endocrinol, 1997 Dec. PMID 9460648
  4. Interleukin-1 beta suppresses growth hormone-induced acid-labile subunit mRNA levels and secretion in primary hepatocytes. Delhanty PJ. Biochem Biophys Res Commun, 1998 Feb 4. PMID 9473516
  5. Changes in the circulating IGF system during short-term fasting and refeeding in rats. Frystyk J, et al. Am J Physiol, 1999 Aug. PMID 10444419

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables insulin-like growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin-like growth factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to epidermal growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to growth hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
part_of insulin-like growth factor ternary complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of insulin-like growth factor ternary complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of insulin-like growth factor ternary complex IEA
Inferred from Electronic Annotation
more info
  
part_of insulin-like growth factor ternary complex ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
insulin-like growth factor-binding protein complex acid labile subunit
Names
insulin-like growth factor-binding protein complex acid labile chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053329.3 → NP_445781.3  insulin-like growth factor-binding protein complex acid labile subunit precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HCX9, F1LRE2, O70211
    Related
    ENSRNOP00000020233.5, ENSRNOT00000020233.7
    Conserved Domains (5) summary
    smart00013
    Location:40 → 78
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:68 → 494
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:244 → 267
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:486 → 536
    LRR_8; Leucine rich repeat
    cl15307
    Location:535 → 578
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    14397076..14408439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086922.2 → XP_038942850.1  insulin-like growth factor-binding protein complex acid labile subunit isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y6E1, A6HCX8, O70211
    Conserved Domains (5) summary
    smart00013
    Location:40 → 78
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:68 → 494
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:244 → 267
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:486 → 536
    LRR_8; Leucine rich repeat
    cl15307
    Location:535 → 578
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  2. XM_063269930.1 → XP_063126000.1  insulin-like growth factor-binding protein complex acid labile subunit isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35859.1 GenPept UniProtKB/Swiss-Prot:P35859

Gene LinkOut

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