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Grid1 glutamate ionotropic receptor delta type subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79219, updated on 2-Nov-2024

Summary

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Symbol
Grid1provided by RGD
Full Name
glutamate ionotropic receptor delta type subunit 1provided by RGD
Primary source
RGD:68366
See related
EnsemblRapid:ENSRNOG00000055499 AllianceGenome:RGD:68366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GluD1
Summary
Enables identical protein binding activity. Predicted to be involved in several processes, including glutamatergic synaptic transmission; regulation of postsynapse organization; and social behavior. Located in postsynaptic membrane. Orthologous to human GRID1 (glutamate ionotropic receptor delta type subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 71.9), Heart (RPKM 10.4) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Grid1 in Genome Data Viewer
Location:
16p15
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (10145018..10894184)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (10138564..10885803)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (11170831..11932197)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 63 Neighboring gene cofilin 1, pseudogene 7 Neighboring gene ribosomal protein L38, pseudogene 3 Neighboring gene microRNA 346 Neighboring gene ral guanine nucleotide dissociation stimulator-like Neighboring gene ral guanine nucleotide dissociation stimulator-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Grid1 regulates the onset of puberty in female rats. Ye J, et al. J Vet Med Sci, 2024 May 6. PMID 38479882, Free PMC Article
  2. Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture. Burada AP, et al. Nat Struct Mol Biol, 2020 Jan. PMID 31925409, Free PMC Article
  3. Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors. Yadav R, et al. PLoS One, 2012. PMID 22412961, Free PMC Article
  4. Differential localization of delta glutamate receptors in the rat cerebellum: coexpression with AMPA receptors in parallel fiber-spine synapses and absence from climbing fiber-spine synapses. Landsend AS, et al. J Neurosci, 1997 Jan 15. PMID 8987804, Free PMC Article
  5. The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family. Lomeli H, et al. FEBS Lett, 1993 Jan 11. PMID 8422924

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in social behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in social behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutamate receptor ionotropic, delta-1
Names
gluR delta-1 subunit
glutamate receptor delta-1 subunit
glutamate receptor ionotropic, delta-1-like
glutamate receptor, ionotropic, delta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024378.3 → NP_077354.1  glutamate receptor ionotropic, delta-1 precursor

    See identical proteins and their annotated locations for NP_077354.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    Q62640, Q63225
    UniProtKB/TrEMBL
    A6KFQ4
    Related
    ENSRNOP00000073010.2, ENSRNOT00000079833.3
    Conserved Domains (4) summary
    cd06392
    Location:25 → 423
    PBP1_iGluR_delta_1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
    cd13730
    Location:436 → 806
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
    pfam00060
    Location:564 → 841
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:41 → 400
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    10145018..10894184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275757.1 → XP_063131827.1  glutamate receptor ionotropic, delta-1 isoform X1

  2. XM_039094853.2 → XP_038950781.1  glutamate receptor ionotropic, delta-1 isoform X2

    UniProtKB/TrEMBL
    A6KFQ4
    Conserved Domains (2) summary
    cd13730
    Location:436 → 806
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
    cd06392
    Location:25 → 425
    PBP1_iGluR_delta_1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family

  3. XM_063275758.1 → XP_063131828.1  glutamate receptor ionotropic, delta-1 isoform X3

  4. XM_063275759.1 → XP_063131829.1  glutamate receptor ionotropic, delta-1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62640.1 GenPept UniProtKB/Swiss-Prot:Q62640

Gene LinkOut

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