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cnmd chondromodulin [ Danio rerio (zebrafish) ]

Gene ID: 791772, updated on 2-Nov-2024

Summary

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Official Symbol
cnmdprovided by ZNC
Official Full Name
chondromodulinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010713-1
See related
Ensembl:ENSDARG00000100133 AllianceGenome:ZFIN:ZDB-GENE-010713-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
chm1; cb298; lect1; fb55b05; wu:fb55b05
Summary
Predicted to be involved in negative regulation of angiogenesis and negative regulation of endothelial cell proliferation. Predicted to act upstream of or within cartilage development and cell differentiation. Predicted to be located in endomembrane system; extracellular region; and membrane. Is expressed in several structures, including cartilage element; cranium; head mesenchyme; hypochord; and lapillus. Orthologous to human CNMD (chondromodulin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cnmd in Genome Data Viewer
Location:
chromosome: 9
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (53725128..53744248)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (54185533..54204653)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496513 Neighboring gene si:ch211-199f5.1 Neighboring gene endothelin receptor type Bb Neighboring gene component of oligomeric golgi complex 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis. Sachdev SW, et al. Mech Dev, 2001 Jul. PMID 11429291
  2. Expression of two novel zebrafish iroquois homologues (ziro1 and ziro5) during early development of axial structures and central nervous system. Wang X, et al. Mech Dev, 2001 Jul. PMID 11429297
  3. Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation. Xu P, et al. Elife, 2021 Jan 27. PMID 33501917, Free PMC Article
  4. Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher. Clément A, et al. PLoS Genet, 2008 Jul 25. PMID 18654627, Free PMC Article
  5. barx1 is necessary for ectomesenchyme proliferation and osteochondroprogenitor condensation in the zebrafish pharyngeal arches. Sperber SM, et al. Dev Biol, 2008 Sep 1. PMID 18590717, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC76820

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cartilage development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leukocyte cell-derived chemotaxin 1
Names
chM-I
chondromodulin-1
chondromodulin-I
leukocyte cell derived chemotaxin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126448.2 → NP_001119920.2  leukocyte cell-derived chemotaxin 1

    Status: VALIDATED

    Source sequence(s)
    EH585281, FP102998
    UniProtKB/Swiss-Prot
    P58239
    UniProtKB/TrEMBL
    A0A0R4IIF8, A0A8M1NGS2
    Related
    ENSDARP00000138747.1, ENSDART00000169062.2
    Conserved Domains (1) summary
    smart01039
    Location:73 → 156
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    53725128..53744248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009305008.4 → XP_009303283.1  leukocyte cell-derived chemotaxin 1 isoform X1

    UniProtKB/Swiss-Prot
    P58239
    UniProtKB/TrEMBL
    A0A0R4IMQ2, A0A8M3BCN7
    Related
    ENSDARP00000136347.1, ENSDART00000165991.2
    Conserved Domains (1) summary
    smart01039
    Location:73 → 156
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58239.1 GenPept UniProtKB/Swiss-Prot:P58239

Gene LinkOut

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