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PRKDC protein kinase, DNA-activated, catalytic subunit [ Equus caballus (horse) ]

Gene ID: 791233, updated on 17-Aug-2024

Summary

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Official Symbol
PRKDCprovided by VGNC
Official Full Name
protein kinase, DNA-activated, catalytic subunitprovided by VGNC
Primary source
VGNC:VGNC:21853
See related
Ensembl:ENSECAG00000020168
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as
DNAPK; DNA-PK
Orthologs
human mouse all
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Genomic context

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See PRKDC in Genome Data Viewer
Location:
chromosome: 9
Exon count:
89
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 9 NC_009152.3 (36236670..36438603)

Chromosome 9 - NC_009152.3Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 V2 Neighboring gene minichromosome maintenance complex component 4 Neighboring gene CCAAT enhancer binding protein delta Neighboring gene scaffold protein involved in DNA repair Neighboring gene 60S ribosomal protein L36 pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009152.3 Chromosome 9 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Linkage of the gene for equine combined immunodeficiency disease to microsatellite markers HTG8 and HTG4; synteny and FISH mapping to ECA9. Bailey E, et al. Anim Genet, 1997 Aug. PMID 9345723
  2. A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation. Shin EK, et al. J Immunol, 1997 Apr 15. PMID 9103416
  3. PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer. Brunner A, et al. Elife, 2020 Jul 6. PMID 32628111, Free PMC Article
  4. DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia. Ding Q, et al. Gene, 2002 Jan 23. PMID 11867233
  5. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer.
    Title: PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immunoglobulin V(D)J recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA-dependent protein kinase catalytic subunit
Names
DNA protein kinase catalytic subunit
protein kinase, DNA-activated, catalytic polypeptide
NP_001157330.1
XP_023504092.1
XP_023504093.1
XP_023504094.1
XP_023504096.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163858.2 → NP_001157330.1  DNA-dependent protein kinase catalytic subunit

    Status: PROVISIONAL

    Source sequence(s)
    PJAA01000010
    UniProtKB/TrEMBL
    A0A3Q2L6Q7
    Conserved Domains (4) summary
    cd05172
    Location:3725 → 4021
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:3030 → 3476
    FAT; FAT domain
    pfam02260
    Location:4104 → 4134
    FATC; FATC domain
    pfam08163
    Location:1817 → 2204
    NUC194; NUC194 domain

RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009152.3 Reference EquCab3.0 Primary Assembly

    Range
    36236670..36438603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023648324.1 → XP_023504092.1  DNA-dependent protein kinase catalytic subunit isoform X1

    UniProtKB/TrEMBL
    A0A3Q2L6Q7, F6RWW4
    Related
    ENSECAP00000018902.2, ENSECAT00000022846.4
    Conserved Domains (5) summary
    cd05172
    Location:3725 → 4020
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:3030 → 3476
    FAT; FAT domain
    pfam02260
    Location:4134 → 4164
    FATC; FATC domain
    pfam08163
    Location:1817 → 2204
    NUC194; NUC194 domain
    cl26692
    Location:3490 → 4042
    FRB_dom; FKBP12-rapamycin binding domain

  2. XM_023648326.1 → XP_023504094.1  DNA-dependent protein kinase catalytic subunit isoform X3

    UniProtKB/TrEMBL
    F6RGR8
    Related
    ENSECAP00000018867.3, ENSECAT00000022809.4
    Conserved Domains (5) summary
    cd05172
    Location:3674 → 3969
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:2979 → 3425
    FAT; FAT domain
    pfam02260
    Location:4083 → 4113
    FATC; FATC domain
    pfam08163
    Location:1766 → 2153
    NUC194; NUC194 domain
    cl26692
    Location:3439 → 3991
    FRB_dom; FKBP12-rapamycin binding domain

  3. XM_023648328.1 → XP_023504096.1  DNA-dependent protein kinase catalytic subunit isoform X4

    UniProtKB/TrEMBL
    A0A3Q2L6Q7
    Conserved Domains (2) summary
    pfam02259
    Location:3030 → 3476
    FAT; FAT domain
    pfam08163
    Location:1817 → 2204
    NUC194; NUC194 domain

  4. XM_023648325.1 → XP_023504093.1  DNA-dependent protein kinase catalytic subunit isoform X2

    UniProtKB/TrEMBL
    Q8WN21
    Conserved Domains (5) summary
    cd05172
    Location:3680 → 3975
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
    pfam02259
    Location:2985 → 3431
    FAT; FAT domain
    pfam02260
    Location:4089 → 4119
    FATC; FATC domain
    pfam08163
    Location:1772 → 2159
    NUC194; NUC194 domain
    cl26692
    Location:3445 → 3997
    FRB_dom; FKBP12-rapamycin binding domain
Nucleotide Protein Strain
Heading Accession and Version

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