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bloc1s6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin [ Danio rerio (zebrafish) ]

Gene ID: 791215, updated on 2-Nov-2024

Summary

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Official Symbol
bloc1s6provided by ZNC
Official Full Name
biogenesis of lysosomal organelles complex-1, subunit 6, pallidinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070112-1862
See related
Ensembl:ENSDARG00000042933 AllianceGenome:ZFIN:ZDB-GENE-070112-1862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pldn; zgc:158718
Summary
Predicted to be involved in intracellular transport. Predicted to be located in cytoplasm. Predicted to be part of BLOC-1 complex. Predicted to be active in transport vesicle. Is expressed in female organism. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 9. Orthologous to human BLOC1S6 (biogenesis of lysosomal organelles complex 1 subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See bloc1s6 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (5505999..5509631, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (5653137..5656769, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene NAD(P) transhydrogenase, mitochondrial Neighboring gene uncharacterized LOC103909115 Neighboring gene muscle-specific beta 1 integrin binding protein 2 Neighboring gene solute carrier family 30 member 4 Neighboring gene zgc:153317

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Gan L, et al. Nat Cell Biol, 2019 May. PMID 31036939, Free PMC Article
  2. The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia. Shen K, et al. Cell Rep, 2016 Jan 26. PMID 26774477, Free PMC Article
  3. Genetic characterization and in vivo image analysis of novel zebrafish Danio rerio pigment mutants. Hsu CC, et al. J Fish Biol, 2013 May. PMID 23639161
  4. Kcnb1 plays a role in development of the inner ear. Jedrychowska J, et al. Dev Biol, 2021 Mar. PMID 33316259
  5. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of BLOC-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
biogenesis of lysosome-related organelles complex 1 subunit 6
Names
pallidin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080697.2 → NP_001074166.2  biogenesis of lysosome-related organelles complex 1 subunit 6

    Status: VALIDATED

    Source sequence(s)
    CU595864, EH586647, EH604090, EH609352
    UniProtKB/TrEMBL
    A0A8M1NBU1, E9QGH2
    Related
    ENSDARP00000122569.1, ENSDART00000142945.3
    Conserved Domains (1) summary
    pfam14712
    Location:34 → 122
    Snapin_Pallidin; Snapin/Pallidin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    5505999..5509631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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