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MAPKAP1 MAPK associated protein 1 [ Homo sapiens (human) ]

Gene ID: 79109, updated on 14-Nov-2024

Summary

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Official Symbol
MAPKAP1provided by HGNC
Official Full Name
MAPK associated protein 1provided by HGNC
Primary source
HGNC:HGNC:18752
See related
Ensembl:ENSG00000119487 MIM:610558; AllianceGenome:HGNC:18752
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIP1; SIN1; JC310; SIN1b; SIN1g
Summary
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 18.8), testis (RPKM 17.4) and 25 other tissues See more
Orthologs
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Genomic context

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See MAPKAP1 in Genome Data Viewer
Location:
9q33.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (125437394..125707208, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137636609..137907172, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (128199673..128469487, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929014 Neighboring gene uncharacterized LOC112268055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128186118-128186618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128194217-128194791 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128207109-128207610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128207611-128208110 Neighboring gene NANOG hESC enhancer GRCh37_chr9:128208606-128209135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128209344-128209872 Neighboring gene RNA, U5B small nuclear 5, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128242575-128243076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128243077-128243576 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:128243732-128243912 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:128246700-128246866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:128257291-128258078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29005 Neighboring gene Sharpr-MPRA regulatory region 1305 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29008 Neighboring gene uncharacterized LOC124902270 Neighboring gene RNA, 7SL, cytoplasmic 30, pseudogene Neighboring gene uncharacterized LOC105376272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128349429-128349928 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29009 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:128407768-128408361 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:128411544-128412743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29013 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:128416201-128417099 Neighboring gene uncharacterized LOC124902358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:128458383-128459122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20278 Neighboring gene Sharpr-MPRA regulatory region 13831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20283 Neighboring gene VISTA enhancer hs1030 Neighboring gene VISTA enhancer hs818 Neighboring gene VISTA enhancer hs1102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128540192-128540692 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:128541469-128542156 Neighboring gene PBX3 divergent transcript Neighboring gene PBX homeobox 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29015 Neighboring gene uncharacterized LOC124902271 Neighboring gene Sharpr-MPRA regulatory region 15662

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation. Yang G, et al. Cell Rep, 2015 Aug 11. PMID 26235620
  2. Localization of mTORC2 activity inside cells. Ebner M, et al. J Cell Biol, 2017 Feb. PMID 28143890, Free PMC Article
  3. Epigenetic activation of SIN1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial-mesenchymal transition. Hu Z, et al. Biochem Biophys Res Commun, 2017 Jan 29. PMID 27993679
  4. The Effect of SIN1 and Microtubules on Insulin Induced PKC ζ Activation. Yingying X, et al. Med Sci Monit, 2017 Jul 28. PMID 28751630, Free PMC Article
  5. SIN1 promotes the proliferation and migration of breast cancer cells by Akt activation. Wang D, et al. Biosci Rep, 2016 Dec. PMID 27780891, Free PMC Article

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of microRNA-611 inhibits TGF-beta-induced epithelial-mesenchymal transition and migration in lung cancer cells through MAPKAP1.
    Title: Overexpression of microRNA-611 inhibits TGF-β-induced epithelial-mesenchymal transition and migration in lung cancer cells through MAPKAP1.
  2. Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2.
    Title: Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2.
  3. Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
    Title: Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
  4. RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
    Title: RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
  5. G-Protein-Coupled Estrogen Receptor 1 Promotes Gender Disparities in Hepatocellular Carcinoma via Modulation of SIN1 and mTOR Complex 2 Activity.
    Title: G-Protein-Coupled Estrogen Receptor 1 Promotes Gender Disparities in Hepatocellular Carcinoma via Modulation of SIN1 and mTOR Complex 2 Activity.
  6. Genetic Predisposition to Glioma Mediated by a MAPKAP1 Enhancer Variant.
    Title: Genetic Predisposition to Glioma Mediated by a MAPKAP1 Enhancer Variant.
  7. Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and androgen receptor signaling cascades.
    Title: Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and AR signaling cascades.
  8. Sin1 is an amplifier of platelet alphaIIbbeta3-mediated outsidein signaling and a susceptible sensor of hypoxia/ROS signaling in ischemic environments after myocardial infarction, inducing microthrombosis.
    Title: Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets.
  9. Lysophosphatidic acids tabilizes mSin1 protein expression via JNK signaling by blocking its proteasomal degradation and identify the LPA/JNK/mSin1/mTORC/collagen I pathway as critical for fibrotic activation of mesenchymal cells.
    Title: c-Jun N-terminal kinase (JNK)-mediated induction of mSin1 expression and mTORC2 activation in mesenchymal cells during fibrosis.
  10. SIN1 interacted and co-located with PKC zeta by pleckstrin homology (PH) domain. Downregulation of SIN1 severely impaired PKC zeta translocation and phosphorylation induced by insulin.
    Title: The Effect of SIN1 and Microtubules on Insulin Induced PKC ζ Activation.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2745

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC2 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to nutrient levels NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cytoskeleton organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in substantia nigra development HEP PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TORC2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
target of rapamycin complex 2 subunit MAPKAP1
Names
MEKK2-interacting protein 1
SAPK-interacting protein 1
TORC2 subunit MAPKAP1
mSIN1
mitogen-activated protein kinase 2-associated protein 1
mitogen-activated protein kinase associated protein 1
ras inhibitor MGC2745
stress-activated map kinase interacting protein 1
stress-activated protein kinase-interacting 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006617.3 → NP_001006618.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 1

    See identical proteins and their annotated locations for NP_001006618.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as Sin1 and Mip1b, represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL162584, AL358074, AL359632
    Consensus CDS
    CCDS35140.1
    UniProtKB/Swiss-Prot
    A8K1Z5, B1AMA4, B7Z309, Q00426, Q5JSV5, Q5JSV6, Q5JSV9, Q658R0, Q699U1, Q699U2, Q699U3, Q699U4, Q6GVJ0, Q6GVJ1, Q6GVJ2, Q9BPZ7
    Related
    ENSP00000265960.3, ENST00000265960.8
    Conserved Domains (3) summary
    cd13331
    Location:383 → 490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18 → 129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:140 → 266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  2. NM_001006618.2 → NP_001006619.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 5

    See identical proteins and their annotated locations for NP_001006619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as Sin1a, differs in the 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 5), also known as the alpha isoform, has a shorter and distinct C-terminus, compared to isoform 1. The existence of this isoform has not been confirmed experimentally.
    Source sequence(s)
    AY524429, AY524430
    Consensus CDS
    CCDS48020.1
    UniProtKB/Swiss-Prot
    Q9BPZ7
    Related
    ENSP00000377624.3, ENST00000394060.7
    Conserved Domains (2) summary
    pfam05422
    Location:18 → 129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:140 → 266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  3. NM_001006619.2 → NP_001006620.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 3

    See identical proteins and their annotated locations for NP_001006620.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as Sin1g, lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 3), also known as the gamma isoform, is shorter, compared to isoform 1.
    Source sequence(s)
    AL162584, AL358074, AL359632
    Consensus CDS
    CCDS35139.1
    UniProtKB/Swiss-Prot
    Q9BPZ7
    Related
    ENSP00000362610.2, ENST00000373511.6
    Conserved Domains (3) summary
    cd13331
    Location:353 → 443
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18 → 129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:140 → 266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  4. NM_001006620.2 → NP_001006621.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 4

    See identical proteins and their annotated locations for NP_001006621.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as Sin1d, lacks an alternate in-frame exon in the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 4), also known as the delta isoform, has a shorter N-terminus, compared to isoform 1. The existence of this isoform has not been confirmed experimentally. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AL162584, AL358074, AL359632
    Consensus CDS
    CCDS35141.1
    UniProtKB/Swiss-Prot
    Q9BPZ7
    Related
    ENSP00000362602.3, ENST00000373503.7
    Conserved Domains (2) summary
    cd13331
    Location:191 → 298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:1 → 74
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  5. NM_001006621.2 → NP_001006622.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 4

    See identical proteins and their annotated locations for NP_001006622.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as Sin1e, lacks two alternate in-frame exons in the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 4), also known as the delta isoform, has a shorter N-terminus, compared to isoform 1. The existence of this isoform has not been confirmed experimentally. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AL162584, AL358074, AL359632
    Consensus CDS
    CCDS35141.1
    UniProtKB/Swiss-Prot
    Q9BPZ7
    Related
    ENSP00000377627.1, ENST00000394063.5
    Conserved Domains (2) summary
    cd13331
    Location:191 → 298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:1 → 74
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

  6. NM_024117.4 → NP_077022.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 2

    See identical proteins and their annotated locations for NP_077022.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as Sin1b and Mip1a, lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2), also known as the beta isoform, is shorter, compared to isoform 1.
    Source sequence(s)
    AL162584, AL358074, AL359632
    Consensus CDS
    CCDS6864.1
    Related
    ENSP00000265961.5, ENST00000350766.7
    Conserved Domains (3) summary
    cd13331
    Location:347 → 454
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18 → 129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:140 → 266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    125437394..125707208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    137636609..137907172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BPZ7.2 GenPept UniProtKB/Swiss-Prot:Q9BPZ7

Gene LinkOut

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