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SLC25A23 solute carrier family 25 member 23 [ Homo sapiens (human) ]

Gene ID: 79085, updated on 2-Nov-2024

Summary

Official Symbol
SLC25A23provided by HGNC
Official Full Name
solute carrier family 25 member 23provided by HGNC
Primary source
HGNC:HGNC:19375
See related
Ensembl:ENSG00000125648 MIM:608746; AllianceGenome:HGNC:19375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC2; MCSC2; SCAMC3; SCaMC-3
Summary
Enables ADP:phosphate antiporter activity and ATP:phosphate antiporter activity. Involved in mitochondrial transmembrane transport; positive regulation of mitochondrial calcium ion concentration; and regulation of cellular hyperosmotic salinity response. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 40.2), thyroid (RPKM 28.7) and 23 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See SLC25A23 in Genome Data Viewer
Location:
19p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6436081..6459792, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6425594..6449293, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6440075..6459803, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adenylate kinase isoenzyme 1-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6411708-6412532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6412533-6413357 Neighboring gene KH-type splicing regulatory protein Neighboring gene microRNA 3940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13824 Neighboring gene solute carrier family 25 member 41 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6464149-6464690 Neighboring gene DENN domain containing 1C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6475606-6476345 Neighboring gene crumbs cell polarity complex component 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6479893-6480392 Neighboring gene Sharpr-MPRA regulatory region 5032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9956 Neighboring gene tubulin beta 4A class IVa

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC2615

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP:phosphate antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP:phosphate antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenine nucleotide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mitochondrial adenyl nucleotide antiporter SLC25A23
Names
calcium-binding mitochondrial carrier protein SCaMC-3
mitochondrial ATP-Mg/Pi carrier protein 2
mitochondrial Ca(2+)-dependent solute carrier protein 2
mitochondrial Ca2+-dependent solute carrier protein 2
short calcium-binding mitochondrial carrier 3
short calcium-binding mitochondrial carrier protein 3
small calcium-binding mitochondrial carrier protein 3
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024103.3NP_077008.2  mitochondrial adenyl nucleotide antiporter SLC25A23

    See identical proteins and their annotated locations for NP_077008.2

    Status: VALIDATED

    Source sequence(s)
    AC010503, AJ619962, AW379976, BC001656, BG706035
    Consensus CDS
    CCDS32882.1
    UniProtKB/Swiss-Prot
    B4DGB6, Q4LBC2, Q705K3, Q86Y43, Q8N2N4, Q96NQ4, Q9BV35
    Related
    ENSP00000301454.3, ENST00000301454.9
    Conserved Domains (3) summary
    COG5126
    Location:7143
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15897
    Location:1245
    EFh_PEF; EF-hand motif [structural motif]
    cl28162
    Location:190463
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    6436081..6459792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439413.1XP_047295369.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X30

  2. XM_047439412.1XP_047295368.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X27

  3. XM_017027287.3XP_016882776.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X14

  4. XM_017027292.3XP_016882781.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X29

  5. XM_047439410.1XP_047295366.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X25

  6. XM_047439407.1XP_047295363.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X20

  7. XM_017027286.3XP_016882775.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X11

  8. XM_047439408.1XP_047295364.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X22

    Related
    ENSP00000334537.4, ENST00000334510.9
  9. XM_047439406.1XP_047295362.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X19

  10. XM_017027288.3XP_016882777.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X15

  11. XM_011528275.3XP_011526577.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X2

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:190463
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:275364
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  12. XM_047439411.1XP_047295367.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X26

  13. XM_011528279.3XP_011526581.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X9

    Conserved Domains (3) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:232319
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  14. XM_047439409.1XP_047295365.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X23

  15. XM_047439405.1XP_047295361.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X16

  16. XM_011528276.3XP_011526578.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X3

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:237454
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:232319
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  17. XM_011528284.3XP_011526586.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X17

    Related
    ENSP00000264088.3, ENST00000264088.8
    Conserved Domains (3) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  18. XM_011528282.3XP_011526584.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X12

    Conserved Domains (3) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  19. XM_011528280.3XP_011526582.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X10

    Conserved Domains (3) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  20. XM_011528283.3XP_011526585.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X13

    Conserved Domains (3) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:82137
    EF-hand_7; EF-hand domain pair
  21. XM_047439404.1XP_047295360.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X8

  22. XM_017027285.3XP_016882774.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X4

  23. XM_011528278.3XP_011526580.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X7

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:237510
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  24. XM_011528277.3XP_011526579.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X5

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:237510
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  25. XM_011528274.3XP_011526576.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X1

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:237510
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:322411
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair
  26. XM_047439403.1XP_047295359.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X6

  27. XM_017027291.3XP_016882780.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X28

    Conserved Domains (3) summary
    COG5126
    Location:7143
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam00153
    Location:185272
    Mito_carr; Mitochondrial carrier protein
    cd15897
    Location:1245
    EFh_PEF; EF-hand motif [structural motif]
  28. XM_017027290.3XP_016882779.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X24

    Conserved Domains (3) summary
    COG5126
    Location:7143
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam00153
    Location:185272
    Mito_carr; Mitochondrial carrier protein
    cd15897
    Location:1245
    EFh_PEF; EF-hand motif [structural motif]
  29. XM_017027289.3XP_016882778.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X21

  30. XM_011528285.3XP_011526587.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X18

    Conserved Domains (4) summary
    cd00051
    Location:85142
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    PTZ00169
    Location:237454
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:232319
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:1675
    EF-hand_7; EF-hand domain pair

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    6425594..6449293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322113.1XP_054178088.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X30

  2. XM_054322110.1XP_054178085.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X27

  3. XM_054322097.1XP_054178072.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X14

  4. XM_054322112.1XP_054178087.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X29

  5. XM_054322108.1XP_054178083.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X25

  6. XM_054322103.1XP_054178078.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X20

  7. XM_054322094.1XP_054178069.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X11

  8. XM_054322105.1XP_054178080.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X22

  9. XM_054322102.1XP_054178077.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X19

  10. XM_054322098.1XP_054178073.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X15

  11. XM_054322085.1XP_054178060.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X2

  12. XM_054322109.1XP_054178084.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X26

  13. XM_054322092.1XP_054178067.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X9

  14. XM_054322106.1XP_054178081.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X23

  15. XM_054322099.1XP_054178074.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X16

  16. XM_054322086.1XP_054178061.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X3

  17. XM_054322100.1XP_054178075.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X17

  18. XM_054322095.1XP_054178070.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X12

  19. XM_054322093.1XP_054178068.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X10

  20. XM_054322096.1XP_054178071.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X13

  21. XM_054322091.1XP_054178066.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X8

  22. XM_054322087.1XP_054178062.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X4

  23. XM_054322090.1XP_054178065.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X7

  24. XM_054322088.1XP_054178063.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X5

  25. XM_054322084.1XP_054178059.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X1

  26. XM_054322089.1XP_054178064.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X6

  27. XM_054322111.1XP_054178086.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X28

  28. XM_054322107.1XP_054178082.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X24

  29. XM_054322104.1XP_054178079.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X21

  30. XM_054322101.1XP_054178076.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X18