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C7orf25 chromosome 7 open reading frame 25 [ Homo sapiens (human) ]

Gene ID: 79020, updated on 3-Nov-2024

Summary

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Official Symbol
C7orf25provided by HGNC
Official Full Name
chromosome 7 open reading frame 25provided by HGNC
Primary source
HGNC:HGNC:21703
See related
Ensembl:ENSG00000136197 AllianceGenome:HGNC:21703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 4.7), kidney (RPKM 3.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See C7orf25 in Genome Data Viewer
Location:
7p14.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (42909273..42912070, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (43067417..43070214, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (42948872..42951669, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr7:42845047-42845574 Neighboring gene t-complex 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18120 Neighboring gene uncharacterized LOC107986735 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:42910171-42910751 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:42915433-42916364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42917594-42918115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42923371-42924173 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42927975-42928518 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:42950498-42951195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:42951196-42951892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25904 Neighboring gene serine-threonine kinase receptor-associated protein-like Neighboring gene proteasome 20S subunit alpha 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25905 Neighboring gene mitochondrial ribosomal protein L32

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease. Bommel H, et al. J Cell Biol, 2002 Nov 25. PMID 12446740, Free PMC Article
  2. MxA interacts with and is modified by the SUMOylation machinery. Brantis-de-Carvalho CE, et al. Exp Cell Res, 2015 Jan 1. PMID 25447205
  3. Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions. Kliche J, et al. Mol Syst Biol, 2023 Jul 11. PMID 37219487, Free PMC Article
  4. RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease. Bishof I, et al. J Biol Chem, 2018 Jul 13. PMID 29802200, Free PMC Article
  5. Comprehensive classification of the PIN domain-like superfamily. Matelska D, et al. Nucleic Acids Res, 2017 Jul 7. PMID 28575517, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2821, FLJ21167

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
UPF0415 protein C7orf25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099858.2 → NP_001093328.2  UPF0415 protein C7orf25

    Status: VALIDATED

    Source sequence(s)
    AC010132
    Consensus CDS
    CCDS5466.1
    UniProtKB/Swiss-Prot
    A4D1V2, J3KR36, Q9BPX7, Q9H779
    UniProtKB/TrEMBL
    B4DQM3
    Related
    ENSP00000343364.4, ENST00000350427.5
    Conserved Domains (2) summary
    pfam07000
    Location:248 → 409
    DUF1308; Protein of unknown function (DUF1308)
    pfam18474
    Location:1 → 218
    DUF5614; Family of unknown function (DUF5614)

  2. NM_001363436.1 → NP_001350365.1  UPF0415 protein C7orf25

    Status: VALIDATED

    Source sequence(s)
    AK024820, BX401140, DB483522, DC303669
    Consensus CDS
    CCDS5466.1
    UniProtKB/Swiss-Prot
    A4D1V2, J3KR36, Q9BPX7, Q9H779
    UniProtKB/TrEMBL
    B4DQM3
    Related
    ENSP00000396597.1, ENST00000438029.1
    Conserved Domains (2) summary
    pfam07000
    Location:248 → 409
    DUF1308; Protein of unknown function (DUF1308)
    pfam18474
    Location:1 → 218
    DUF5614; Family of unknown function (DUF5614)

  3. NM_024054.3 → NP_076959.2  UPF0415 protein C7orf25

    See identical proteins and their annotated locations for NP_076959.2

    Status: VALIDATED

    Source sequence(s)
    AK024820, BC000769, DC303669, DC366585
    Consensus CDS
    CCDS5466.1
    UniProtKB/Swiss-Prot
    A4D1V2, J3KR36, Q9BPX7, Q9H779
    UniProtKB/TrEMBL
    B4DQM3
    Conserved Domains (2) summary
    pfam07000
    Location:248 → 409
    DUF1308; Protein of unknown function (DUF1308)
    pfam18474
    Location:1 → 218
    DUF5614; Family of unknown function (DUF5614)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    42909273..42912070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420827.1 → XP_047276783.1  UPF0415 protein C7orf25 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    43067417..43070214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358989.1 → XP_054214964.1  UPF0415 protein C7orf25 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BPX7.1 GenPept UniProtKB/Swiss-Prot:Q9BPX7

Gene LinkOut

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