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ADF actin depolymerizing factor ADF [ Toxoplasma gondii ME49 ]

Gene ID: 7893682, updated on 26-Oct-2024

Summary

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Gene symbol
ADF
Gene description
actin depolymerizing factor ADF
Locus tag
TGME49_220400
See related
ToxoDB:TGME49_220400; VEuPathDB:TGME49_220400
Gene type
protein coding
RNA name
actin depolymerizing factor ADF
RefSeq status
PROVISIONAL
Organism
Toxoplasma gondii ME49 (strain: ME49)
Lineage
Eukaryota; Alveolata; Apicomplexa; Conoidasida; Coccidia; Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma
Old locus tag
TGME49_020400
Orthologs
all
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Genomic context

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Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_031472.1 (352732..354045, complement)

Chromosome V - NC_031472.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Neighboring gene tRNA-Arg Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_031472.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solution structure and dynamics of ADF from Toxoplasma gondii. Yadav R, et al. J Struct Biol, 2011 Oct. PMID 21820516, Free PMC Article
  2. Actin depolymerizing factor controls actin turnover and gliding motility in Toxoplasma gondii. Mehta S, et al. Mol Biol Cell, 2011 Apr 15. PMID 21346192, Free PMC Article
  3. Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin. Mehta S, et al. J Biol Chem, 2010 Feb 26. PMID 20042603, Free PMC Article
  4. Toxoplasma gondii deoxyribose phosphate aldolase-like protein (TgDPA) interacts with actin depolymerizing factor (TgADF) to enhance the actin filament dynamics in the bradyzoite stage. Ueno A, et al. Mol Biochem Parasitol, 2010 Sep. PMID 20433874
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Solution structure and dynamics of ADF from Toxoplasma gondii
    Title: Solution structure and dynamics of ADF from Toxoplasma gondii.
  2. Actin depolymerizing factor controls actin turnover and gliding motility in Toxoplasma gondii.
    Title: Actin depolymerizing factor controls actin turnover and gliding motility in Toxoplasma gondii.
  3. Deoxyribose phosphate aldolase-like protein interacts with actin depolymerizing factor to enhance the actin filament dynamics in the bradyzoite stage.
    Title: Toxoplasma gondii deoxyribose phosphate aldolase-like protein (TgDPA) interacts with actin depolymerizing factor (TgADF) to enhance the actin filament dynamics in the bradyzoite stage.
  4. dual role for TgADF in maintaining high G-actin concentrations and effecting rapid filament turnover.
    Title: Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Names
actin depolymerizing factor ADF
XP_002371565.1
  • encoded by transcript TGME49_220400
    Gene product name based on ToxoDB Community Expert Annotation.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_031472.1 Reference assembly

    Range
    352732..354045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002371524.2 → XP_002371565.1  actin depolymerizing factor ADF [Toxoplasma gondii ME49]

    See identical proteins and their annotated locations for XP_002371565.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A086J855, A0A086JEA4, A0A086JTG3, A0A086M2A1, A0A086PI60, A0A086PYD3, A0A0F7UUE8, A0A125YJR5, A0A139XXR9, A0A151H1R1, A0A2G8XY76, A0A2T6IF24, A0A3R8AGF2, A0A7J6KAH7, B9Q2C8, B9QPU9, S7VPG2, S8GGZ6
    Conserved Domains (1) summary
    PTZ00152
    Location:1 → 118
    PTZ00152; cofilin/actin-depolymerizing factor 1-like protein; Provisional
Nucleotide Protein
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Gene LinkOut

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Molecular Biology Databases
Research Materials