tyro3 TYRO3 protein tyrosine kinase [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: tyro3provided by Xenbase
Official Full Name: TYRO3 protein tyrosine kinaseprovided by Xenbase
Primary source: Xenbase:XB-GENE-922144
See related: Ensembl:ENSXETG00000000052 AllianceGenome:Xenbase:XB-GENE-922144
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: brt; byk; dtk; rse; sky; tif; Xksy
Summary: Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including cell migration; cell surface receptor protein tyrosine kinase signaling pathway; and phagocytosis. Predicted to act upstream of or within cell adhesion and protein phosphorylation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human TYRO3 (TYRO3 protein tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (105198703..105305192, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	8	NC_030684.1 (84892063..84989630, complement)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase receptor TYRO3

NP_001072731.1

EC 2.7.10.1

XP_012824144.1

EC 2.7.10.1

XP_031746456.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079263.1 → NP_001072731.1 tyrosine-protein kinase receptor TYRO3 precursor

See identical proteins and their annotated locations for NP_001072731.1

Status: PROVISIONAL

Source sequence(s)

BC125706

UniProtKB/Swiss-Prot

A0JM20

UniProtKB/TrEMBL

A0A6I8QYX9

Related

ENSXETP00000060585.1, ENSXETT00000063715.3

Conserved Domains (5) summary

cd05749
Location:127 → 206

Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)

smart00408
Location:42 → 108

IGc2; Immunoglobulin C-2 Type

cd00063
Location:211 → 303

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05074
Location:493 → 776

PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3

pfam00041
Location:312 → 390

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

105198703..105305192 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012968690.3 → XP_012824144.1 tyrosine-protein kinase receptor TYRO3 isoform X1

UniProtKB/TrEMBL

A0A6I8QYX9, A0A8J0SWM1

Conserved Domains (8) summary

cd05749
Location:127 → 206

Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)

smart00408
Location:42 → 108

IGc2; Immunoglobulin C-2 Type

smart00410
Location:131 → 207

IG_like; Immunoglobulin like

cd00063
Location:211 → 328

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:31 → 116

I-set; Immunoglobulin I-set domain

cd05074
Location:518 → 801

PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3

pfam00041
Location:337 → 416

fn3; Fibronectin type III domain

pfam07714
Location:528 → 796

Pkinase_Tyr; Protein tyrosine kinase
XM_031890596.1 → XP_031746456.1 tyrosine-protein kinase receptor TYRO3 isoform X2

UniProtKB/TrEMBL

A0A6I8QYX9, A0A8J1IPM3

Conserved Domains (5) summary

cd00063
Location:68 → 185

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05074
Location:375 → 658

PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3

pfam00041
Location:194 → 273

fn3; Fibronectin type III domain

cd00096
Location:11 → 18

Ig; Ig strand C [structural motif]

cl11960
Location:1 → 63

Ig; Immunoglobulin domain