grin1 glutamate ionotropic receptor NMDA type subunit 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: grin1provided by Xenbase
Official Full Name: glutamate ionotropic receptor NMDA type subunit 1provided by Xenbase
Primary source: Xenbase:XB-GENE-494200
See related: Ensembl:ENSXETG00000022933 AllianceGenome:Xenbase:XB-GENE-494200
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: NR1; nmda1; nmdar1
Summary: Predicted to enable ligand-gated monoatomic ion channel activity and signaling receptor activity. Predicted to act upstream of or within ionotropic glutamate receptor signaling pathway and monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of NMDA selective glutamate receptor complex. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy 101. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (1606495..1657500)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	Unplaced Scaffold	NW_016683614.1 (37841..72687, complement)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that amplitudes of agonist-induced currents show little dependency on the C-terminally spliced NR1 variants in NR1/NR3B diheteromers.
Title: Effects of NR1 splicing on NR1/NR3B-type excitatory glycine receptors.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 1

Names: glutamate receptor, ionotropic, N-methyl D-aspartate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079125.1 → NP_001072593.1 glutamate receptor ionotropic, NMDA 1 precursor

See identical proteins and their annotated locations for NP_001072593.1

Status: PROVISIONAL

Source sequence(s)

BC122961

UniProtKB/TrEMBL

A0A1B8Y0N3, Q05B24

Related

ENSXETP00000072024.2, ENSXETT00000079588.2

Conserved Domains (3) summary

cd06379
Location:18 → 383

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:395 → 797

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10562
Location:833 → 861

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

1606495..1657500

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_031890572.1 → XP_031746432.1 glutamate receptor ionotropic, NMDA 1 isoform X10

UniProtKB/TrEMBL

A0A1B8Y0Q0, A0A8J1ILR3

Conserved Domains (3) summary

cd13719
Location:271 → 673

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10562
Location:709 → 737

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cl10011
Location:1 → 259

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_031890571.1 → XP_031746431.1 glutamate receptor ionotropic, NMDA 1 isoform X9

UniProtKB/TrEMBL

A0A1B8Y0Q0, A0A8J1IPJ9

Conserved Domains (3) summary

cd13719
Location:292 → 694

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam10562
Location:730 → 758

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cl10011
Location:1 → 280

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_031890569.1 → XP_031746429.1 glutamate receptor ionotropic, NMDA 1 isoform X2

UniProtKB/TrEMBL

A0A6I8QUI0, F7CS95

Related

ENSXETP00000049600.4, ENSXETT00000049600.5

Conserved Domains (3) summary

cd13719
Location:416 → 818

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06379
Location:25 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

pfam10562
Location:854 → 882

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_031890570.1 → XP_031746430.1 glutamate receptor ionotropic, NMDA 1 isoform X2

UniProtKB/TrEMBL

A0A6I8QUI0, F7CS95

Related

ENSXETP00000083969.2, ENSXETT00000080222.2

Conserved Domains (3) summary

cd13719
Location:416 → 818

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06379
Location:25 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

pfam10562
Location:854 → 882

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_012969767.3 → XP_012825221.1 glutamate receptor ionotropic, NMDA 1 isoform X4

UniProtKB/TrEMBL

A0A1B8Y0N3, A0A8J0SWD4

Conserved Domains (6) summary

cd06379
Location:18 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:416 → 818

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:580 → 843

Lig_chan; Ligand-gated ion channel

pfam01094
Location:39 → 378

ANF_receptor; Receptor family ligand binding region

pfam07885
Location:621 → 675

Ion_trans_2; Ion channel

pfam10562
Location:854 → 882

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_012969766.3 → XP_012825220.1 glutamate receptor ionotropic, NMDA 1 isoform X1

UniProtKB/TrEMBL

A0A1B8Y0N3, A0A803KAR9

Related

ENSXETP00000117498.1, ENSXETT00000117405.1

Conserved Domains (4) summary

cd13719
Location:416 → 818

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam07885
Location:620 → 675

Ion_trans_2; Ion channel

pfam10562
Location:854 → 882

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cd06379
Location:25 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
XM_012969770.3 → XP_012825224.1 glutamate receptor ionotropic, NMDA 1 isoform X6

UniProtKB/TrEMBL

A0A1B8Y0P4, A0A8J0SMF7

Related

ENSXETP00000100456.2, ENSXETT00000082534.2

Conserved Domains (5) summary

cd06379
Location:18 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:416 → 818

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:580 → 843

Lig_chan; Ligand-gated ion channel

pfam01094
Location:39 → 378

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:854 → 882

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_012969772.3 → XP_012825226.1 glutamate receptor ionotropic, NMDA 1 isoform X8

UniProtKB/TrEMBL

A0A1B8Y0P8, A0A8J0SWE0

Conserved Domains (5) summary

cd06379
Location:18 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:416 → 818

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:580 → 843

Lig_chan; Ligand-gated ion channel

pfam01094
Location:39 → 378

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:854 → 882

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_012969769.3 → XP_012825223.1 glutamate receptor ionotropic, NMDA 1 isoform X5

UniProtKB/TrEMBL

A0A1B8Y0P8, A0A6I8QSJ4

Related

ENSXETP00000072206.2, ENSXETT00000094935.2

Conserved Domains (4) summary

cd13719
Location:416 → 818

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam07885
Location:620 → 675

Ion_trans_2; Ion channel

pfam10562
Location:854 → 882

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cd06379
Location:25 → 404

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor
XM_012969768.3 → XP_012825222.1 glutamate receptor ionotropic, NMDA 1 isoform X3

UniProtKB/TrEMBL

A0A1B8Y0N3, A0A6I8RU42, A0A6I8T169

Related

ENSXETP00000088414.2, ENSXETT00000081985.2

Conserved Domains (5) summary

cd06379
Location:18 → 383

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

cd13719
Location:395 → 797

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:559 → 822

Lig_chan; Ligand-gated ion channel

pfam01094
Location:39 → 357

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:833 → 861

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
XM_012969771.3 → XP_012825225.1 glutamate receptor ionotropic, NMDA 1 isoform X7

UniProtKB/TrEMBL

A0A1B8Y0P8, F7CS79

Related

ENSXETP00000049601.5, ENSXETT00000049601.5

Conserved Domains (4) summary

cd13719
Location:395 → 797

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam07885
Location:599 → 654

Ion_trans_2; Ion channel

pfam10562
Location:833 → 861

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cd06379
Location:25 → 383

PBP1_iGluR_NMDA_NR1; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor