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ednrb endothelin receptor type B [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 779931, updated on 4-Nov-2024

Summary

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Official Symbol
ednrbprovided by Xenbase
Official Full Name
endothelin receptor type Bprovided by Xenbase
Primary source
Xenbase:XB-GENE-963709
See related
Ensembl:ENSXETG00000015454 AllianceGenome:Xenbase:XB-GENE-963709
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
etb; etrb; hscr; abcds; hscr2; ednrb1-a
Summary
Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; and protein N-linked glycosylation. Predicted to act upstream of or within several processes, including G protein-coupled receptor signaling pathway; enteric nervous system development; and vasoconstriction. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg syndrome (multiple); asthma; and pulmonary hypertension. Orthologous to human EDNRB (endothelin receptor type B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ednrb in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (125830520..125881911)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (122500539..122551443)

Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101732680 Neighboring gene uncharacterized LOC105946542 Neighboring gene uncharacterized protein K02A2.6-like Neighboring gene SLAIN motif family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC145633

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables endothelin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP-N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blood circulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within enteric nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of biological quality IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vasoconstriction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
endothelin receptor type B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079008.1 → NP_001072476.1  endothelin receptor type B precursor

    See identical proteins and their annotated locations for NP_001072476.1

    Status: PROVISIONAL

    Source sequence(s)
    BC121898
    UniProtKB/TrEMBL
    Q0P4U7
    Related
    ENSXETP00000033726.4, ENSXETT00000033726.5
    Conserved Domains (1) summary
    cd15976
    Location:93 → 388
    7tmA_ET-BR; endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    125830520..125881911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012957268.3 → XP_012812722.1  endothelin receptor type B isoform X1

    See identical proteins and their annotated locations for XP_012812722.1

    UniProtKB/TrEMBL
    F6RQM0
    Conserved Domains (1) summary
    cd15976
    Location:94 → 389
    7tmA_ET-BR; endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_012957271.3 → XP_012812725.1  endothelin receptor type B isoform X2

    UniProtKB/TrEMBL
    A0A8J0SG48
    Conserved Domains (1) summary
    pfam00001
    Location:67 → 333
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. XM_012957269.3 → XP_012812723.1  endothelin receptor type B isoform X1

    See identical proteins and their annotated locations for XP_012812723.1

    UniProtKB/TrEMBL
    F6RQM0
    Conserved Domains (1) summary
    cd15976
    Location:94 → 389
    7tmA_ET-BR; endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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