zyx zyxin [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: zyxprovided by Xenbase
Official Full Name: zyxinprovided by Xenbase
Primary source: Xenbase:XB-GENE-6453993
See related: Ensembl:ENSXETG00000046190 AllianceGenome:Xenbase:XB-GENE-6453993
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: esp-2; hed-2; zyx-a; zyx-b
Summary: Predicted to enable DNA-binding transcription factor binding activity. Predicted to be involved in integrin-mediated signaling pathway and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in anchoring junction and cytoskeleton. Predicted to be active in cytoplasm; focal adhesion; and stress fiber. Orthologous to human ZYX (zyxin). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	7	NC_030683.2 (943774..950674)

Chromosome 7 - NC_030683.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_030683.2 Chromosome 7 Reference UCB_Xtro_10.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zyxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001078797.1 → NP_001072265.1 zyxin

See identical proteins and their annotated locations for NP_001072265.1

Status: PROVISIONAL

Source sequence(s)

BC121255

UniProtKB/Swiss-Prot

Q0VA45

UniProtKB/TrEMBL

A0A803JGV2

Related

ENSXETP00000107127.1, ENSXETT00000105286.1

Conserved Domains (3) summary

cd09349
Location:449 → 536

LIM1_Zyxin; The first LIM domain of Zyxin

cd09435
Location:603 → 669

LIM3_Zyxin; The third LIM domain of Zyxin

cl02475
Location:543 → 602

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers