U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

epha4.S EPH receptor A4 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 779062, updated on 4-Nov-2024

Summary

Official Symbol
epha4.S
Official Full Name
EPH receptor A4 S homeolog
Primary source
Xenbase:XB-GENE-6253098
Locus tag
XELAEV_18029854mg
See related
EnsemblRapid:ENSXLAG00005003235 AllianceGenome:Xenbase:XB-GENE-6253098
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
Pag; sek; hek8; rtk1; sek1; epha4; sek-1; tyr01; XEpha4; eph-a4; epha4-a; epha4-b; epha4.L; Pagliaccio
Summary
Predicted to enable GPI-linked ephrin receptor activity and transmembrane-ephrin receptor activity. Predicted to act upstream of or within several processes, including axon guidance; ephrin receptor signaling pathway; and protein phosphorylation. Predicted to be located in early endosome membrane and plasma membrane. Is expressed in anatomical system; mesenchyme; pharyngeal arch; and primary germ layer. Orthologous to human EPHA4 (EPH receptor A4). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See epha4.S in Genome Data Viewer
Location:
chromosome: 5S
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5S NC_054380.1 (112401465..112456534, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5S NC_030733.1 (105646285..105701164, complement)

Chromosome 5S - NC_054380.1Genomic Context describing neighboring genes Neighboring gene putative serine protease K12H4.7 Neighboring gene serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 S homeolog Neighboring gene paired box 3 S homeolog Neighboring gene sphingosine-1-phosphate phosphatase 2 S homeolog

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GPI-linked ephrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane-ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane-ephrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ephrin type-A receptor 4-A
Names
EPH receptor A4 L homeolog
receptor tyrosin kinase
tyrosine-protein kinase receptor SEK-1
xSEK-1
NP_001090183.1
XP_018120100.1
XP_018120101.1
XP_018120102.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096714.1NP_001090183.1  ephrin type-A receptor 4-A precursor

    See identical proteins and their annotated locations for NP_001090183.1

    Status: PROVISIONAL

    Source sequence(s)
    X91191
    UniProtKB/Swiss-Prot
    Q91694, Q91845
    Related
    ENSXLAP00005009643.1, ENSXLAT00005009799.1
    Conserved Domains (7) summary
    cd09545
    Location:911981
    SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
    smart00454
    Location:908975
    SAM; Sterile alpha motif
    cd10482
    Location:30203
    EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
    cd00063
    Location:440531
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:615881
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:620877
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:551615
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    112401465..112456534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018264613.2XP_018120102.1  ephrin type-A receptor 4-A isoform X3

    UniProtKB/Swiss-Prot
    Q91694
    UniProtKB/TrEMBL
    A0A8J0VDQ9
  2. XM_018264612.2XP_018120101.1  ephrin type-A receptor 4-A isoform X2

    UniProtKB/Swiss-Prot
    Q91694
    UniProtKB/TrEMBL
    A0A8J0VAU6
    Related
    ENSXLAP00005009686.1, ENSXLAT00005009842.1
  3. XM_018264611.2XP_018120100.1  ephrin type-A receptor 4-A isoform X1

    UniProtKB/Swiss-Prot
    Q91694
    UniProtKB/TrEMBL
    A0A8J0VE21