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thrb.L thyroid hormone receptor, beta L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 779054, updated on 18-Sep-2024

Summary

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Official Symbol
thrb.L
Official Full Name
thyroid hormone receptor, beta L homeolog
Primary source
Xenbase:XB-GENE-6070716
Locus tag
XELAEV_18031049mg
See related
EnsemblRapid:ENSXLAG00005012948
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
TRB; grth; prth; thr1; erba2; nr1a2; thrb1; TRbeta; thrb-a; thrb-b; nr1a2-a; thrbetaA; erba-beta
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See thrb.L in Genome Data Viewer
Location:
chromosome: 6L
Exon count:
6
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (48312694..48319441, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (44531951..44538698, complement)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15 L homeolog Neighboring gene nuclear receptor subfamily 1 group D member 2 L homeolog Neighboring gene retinoic acid receptor beta L homeolog Neighboring gene protein kinase C-like 1B Neighboring gene protein kinase C-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vitro and in vivo analysis of the thyroid system-disrupting activities of brominated phenolic and phenol compounds in Xenopus laevis. Kudo Y, et al. Toxicol Sci, 2006 Jul. PMID 16627555
  2. In vitro and in vivo analysis of the thyroid disrupting activities of phenolic and phenol compounds in Xenopus laevis. Kudo Y, et al. Toxicol Sci, 2005 Mar. PMID 15590892
  3. The effects of endocrine-disrupting chemicals on thyroid hormone binding to Xenopus laevis transthyretin and thyroid hormone receptor. Yamauchi K, et al. Clin Chem Lab Med, 2002 Dec. PMID 12553426
  4. A role for nucleosome assembly in both silencing and activation of the Xenopus TR beta A gene by the thyroid hormone receptor. Wong J, et al. Genes Dev, 1995 Nov 1. PMID 7590246
  5. Xenopus laevis alpha and beta thyroid hormone receptors. Yaoita Y, et al. Proc Natl Acad Sci U S A, 1990 Nov. PMID 2236080, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that forced expression of Kruppel-like factor 9 (Klf9) in the brain of thyroid-intact tadpoles increased baseline thyroid hormone receptor-beta (trb) mRNA and enhanced trb autoinduction.
    Title: A Mechanism to Enhance Cellular Responsivity to Hormone Action: Krüppel-Like Factor 9 Promotes Thyroid Hormone Receptor-β Autoinduction During Postembryonic Brain Development.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IC
Inferred by Curator
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thyroid hormone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within thyroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thyroid hormone receptor beta-A
Names
TRbetaA
nuclear receptor subfamily 1 group A member 2-A
xTR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096713.1 → NP_001090182.1  thyroid hormone receptor beta-A

    See identical proteins and their annotated locations for NP_001090182.1

    Status: PROVISIONAL

    Source sequence(s)
    M35360
    UniProtKB/Swiss-Prot
    P18116, P18117
    UniProtKB/TrEMBL
    A0A974CNF0
    Related
    ENSXLAP00005038468.1, ENSXLAT00005039380.1
    Conserved Domains (2) summary
    cd06935
    Location:128 → 370
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:18 → 104
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    48312694..48319441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18117.1 GenPept UniProtKB/Swiss-Prot:P18117

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.