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ERN2 endoplasmic reticulum to nucleus signaling 2 [ Gallus gallus (chicken) ]

Gene ID: 771230, updated on 17-Aug-2024

Summary

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Symbol
ERN2provided by CGNC
Full Name
endoplasmic reticulum to nucleus signaling 2provided by CGNC
Primary source
CGNC:56617
See related
Ensembl:ENSGALG00010017120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See ERN2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (6911557..6920390, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (6907449..6916285, complement)

Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene partner and localizer of BRCA2 Neighboring gene dynactin subunit 5 Neighboring gene polo like kinase 1 Neighboring gene ubiquitin family domain containing 1 Neighboring gene glutamyl-tRNA synthetase 2, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An expressed sequence tag analysis of the chicken reproductive tract transcriptome. Froman DP, et al. Poult Sci, 2006 Aug. PMID 16903475
  2. Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index. Carre W, et al. Physiol Genomics, 2006 May 16. PMID 16554550
  3. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  4. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of IRE1-TRAF2-ASK1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase/endoribonuclease IRE2
Names
serine/threonine-protein kinase/endoribonuclease IRE1
NP_001272430.2
XP_015149741.2
XP_046783517.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285501.2 → NP_001272430.2  serine/threonine-protein kinase/endoribonuclease IRE2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000257
    UniProtKB/TrEMBL
    A0A8V0Z6T1
    Related
    ENSGALP00010024197.1, ENSGALT00010041316.1
    Conserved Domains (3) summary
    cd09769
    Location:35 → 303
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:822 → 947
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:554 → 819
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    6911557..6920390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015294255.4 → XP_015149741.2  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1

    Conserved Domains (3) summary
    cd09769
    Location:35 → 303
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:814 → 932
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:554 → 793
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

RNA

  1. XR_005839737.2 RNA Sequence

  2. XR_001468965.4 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    6907449..6916285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046927561.1 → XP_046783517.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1

RNA

  1. XR_006936204.1 RNA Sequence

  2. XR_006936205.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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