GNRH1 gonadotropin releasing hormone 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: GNRH1provided by CGNC
Official Full Name: gonadotropin releasing hormone 1provided by CGNC
Primary source: CGNC:162
See related: Ensembl:ENSGALG00010018891
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: GnRH-I; LHRH-I; CGNRH-I
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	22	NC_052553.1 (882800..885803)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	22	NC_052594.1 (896228..899231)

Chromosome 22 - NC_052553.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The haplogroups of GnRHI had a significant effect on body weight and egg production up to 64 weeks of age, yolk content, Haugh units and egg shell parameters. The h1h2 haplogroup of the GnRHI gene showed the highest egg production, with 211.0 +/- 24.3 eggs up to 64 weeks of age, while the highest yolk content and Haugh unit was found in h3h10 haplogrouped birds.
Title: Polymorphisms in GnRHI and GnRHII genes and their association with egg production and egg quality traits in chicken.
Data show that the gonadotropin-releasing hormone (GnRH) protein was discovered to be expressed successfully in Escherichia coli BL21 cells.
Title: Molecular cloning and characterization, and prokaryotic expression of the GnRH1 gene obtained from Jinghai yellow chicken.
analysis of gonadotropin-releasing hormone ligand conformation and receptor selectivity
Title: Evolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity.
results indicate that GnRH-I expression is correlated with the reproductive state in the native Thai chicken and may be, in part, regulated by it; study also confirms a pivotal role of GnRH-I in controlling avian reproduction of this non-seasonal breeding, equatorial species
Title: Distribution and variation in gonadotropin releasing hormone-I (GnRH-I) immunoreactive neurons in the brain of the native Thai chicken during the reproductive cycle.
FGF signaling is required and sufficient to induce GnRH-1 neurons in the olfactory placode, where they are specified shortly after olfactory sensory neurons.
Title: Specification of GnRH-1 neurons by antagonistic FGF and retinoic acid signaling.
GNRH1 stimulates LH release from the pituitary in vivo with differences in response between males and females
Title: Sex differences in the LH responses to chicken LHRH-I and -II in the domestic fowl.
High and moderate pulse frequencies of chicken GnRH-I (15-30 min) increased the FSH release from FSH cells while low pulse frequency (60 min) of cGnRH-I increased LH release.
Title: Effects of differential pulse frequencies of chicken gonadotrophin-releasing hormone-I (cGnRH-I) on laying hen gonadotrope responses in vitro.
These results provide evidence that netrin 1 acts as chemoattractant to migrating GnRH neurons at the dorsocaudal part of the septum and has the potential to regulate the ventral migration of GnRH neurons to the ventral septum and the preoptic area.
Title: Netrin 1 provides a chemoattractive cue for the ventral migration of GnRH neurons in the chick forebrain.

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General gene information

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Markers

ROS0058 (e-PCR), detects polymorphism
- UniSTS:280264

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables gonadotropin hormone-releasing hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: progonadoliberin-1

Names: Gonadotrophin releasing hormone I; chicken gonadotrophin releasing hormone-I; gonadotrophin-releasing hormone I; gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); luteinizing hormone releasing hormone I; progonadoliberin I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.