EDN3 endothelin 3 [Gallus gallus (chicken)] - Gene

Summary

Symbol: EDN3provided by CGNC
Full Name: endothelin 3provided by CGNC
Primary source: CGNC:66601
See related: Ensembl:ENSGALG00010016253
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	20	NC_052551.1 (11141887..11158648, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	20	NC_052592.1 (10929220..10946062, complement)

Chromosome 20 - NC_052551.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

EDN3 expression is increased in the developing Silkie embryo during the time in which melanoblasts are migrating, and elevated levels of expression are maintained in the adult skin tissue.
Title: A complex genomic rearrangement involving the endothelin 3 locus causes dermal hyperpigmentation in the chicken.
Increased expression associated with dermal hyperpigmentation in Fibromelanosis mutant chickens.
Title: A complex genomic rearrangement involving the endothelin 3 locus causes dermal hyperpigmentation in the chicken.
Influences neural crest cell proliferation, differentiation, and migration.
Title: Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system.

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Function	Evidence Code	Pubs
enables endothelin B receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of prostaglandin-endoperoxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of systemic arterial blood pressure by endothelin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vein smooth muscle contraction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain