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MZF1 myeloid zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 7593, updated on 2-Nov-2024

Summary

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Official Symbol
MZF1provided by HGNC
Official Full Name
myeloid zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:13108
See related
Ensembl:ENSG00000099326 MIM:194550; AllianceGenome:HGNC:13108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen (RPKM 4.6), prostate (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

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See MZF1 in Genome Data Viewer
Location:
19q13.43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58561932..58573573, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61659609..61672553, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59073299..59084940, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59067095-59067778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15211 Neighboring gene ubiquitin conjugating enzyme E2 M Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59070738-59071334 Neighboring gene MZF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11096 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59083407-59084268 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59084269-59085128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15214 Neighboring gene CENPB DNA-binding domains containing 2, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59093108-59093611 Neighboring gene uncharacterized LOC107987272

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MZF1 mediates oncogene-induced senescence by promoting the transcription of p16(INK4A). Wu D, et al. Oncogene, 2022 Jan. PMID 34773072, Free PMC Article
  2. Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro. Bavisotto L, et al. J Exp Med, 1991 Nov 1. PMID 1719120, Free PMC Article
  3. Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein. Peterson MJ, et al. Gene, 2000 Aug 22. PMID 10974541
  4. Haplotype of single nucleotide polymorphisms in exon 6 of the MZF-1 gene and Alzheimer's disease. Porcellini E, et al. J Alzheimers Dis, 2013. PMID 23241556
  5. Expression of myeloid zinc finger 1 and the correlation to clinical aspects of oral squamous cell carcinoma. Ko CP, et al. Tumour Biol, 2015 Sep. PMID 25877752

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant Progression of Hepatocellular Carcinoma.
    Title: LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant Progression of Hepatocellular Carcinoma.
  2. MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription.
    Title: MZF1 alleviates oxidative stress and apoptosis induced by rotenone in SH-SY5Y cells by promoting RBM3 transcription.
  3. MZF1 mediates oncogene-induced senescence by promoting the transcription of p16(INK4A).
    Title: MZF1 mediates oncogene-induced senescence by promoting the transcription of p16(INK4A).
  4. Cigarette smoke modulates binding of the transcription factor MZF1 to the VEGF promoter and regulates VEGF expression in dependence of genetic variation SNP 405.
    Title: Cigarette smoke modulates binding of the transcription factor MZF1 to the VEGF promoter and regulates VEGF expression in dependence of genetic variation SNP 405.
  5. Metallothionein 2A (MT2A)/myeloid zinc-finger 1 (MZF1) may serve as a prognostic marker and a therapeutic target for human gastric cancer.
    Title: Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human Gastric Carcinogenesis by Interacting with Metallothionein 2A.
  6. Exogenous expression of the acidic domain of MZF1 repressed the binding of endogenous MZF1 to IGF1R promoter via blocking the interaction with ETS-like gene 1 (ELK1). This blockage not only caused MZF1 protein degradation, but also restrained ELK1 nuclear localization in high-level MZF1-expressing TNBC cells. MZF1, but not ELK1, was necessary for the retention of mesenchymal phenotype by repressing IGF1R promoter activity
    Title: Myeloid Zinc Finger 1 (MZF1) Maintains the Mesenchymal Phenotype by Down-regulating IGF1R/p38 MAPK/ERα Signaling Pathway in High-level MZF1-expressing TNBC cells.
  7. Mechanistically, FTO enhanced MZF1 expression by reducing m(6)A levels and mRNA stability in MZF1 mRNA transcript, leading to oncogenic functions.
    Title: m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.
  8. MZF1 gene expression was not significantly correlated with PYROXD2 protein expression in the samples of resected tumor tissues, which revealed that the PYROXD2 promoter transcription activity was determined by the aggregated effect of numerous transcription factors. This finding may be helpful in understanding the underlying mechanism which regulates the PYROXD2 expression.
    Title: Myeloid zinc finger 1 protein is a key transcription stimulating factor of PYROXD2 promoter.
  9. PAX2 is involved in the carcinogenesis of endometrial cancer by stimulating cell growth and promoting cell motility; the overexpression of PAX2 in endometrial cancer is regulated by promoter hypermethylation and the transcription factor MZF1
    Title: DNA methylation promotes paired box 2 expression via myeloid zinc finger 1 in endometrial cancer.
  10. miR-337-3p directly binds to the MMP-14 promoter to repress MZF1-facilitatd MMP-14 expression, thus suppressing the progression of gastric cancer
    Title: miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
myeloid zinc finger 1
Names
zinc finger and SCAN domain-containing protein 6
zinc finger protein 42 (myeloid-specific retinoic acid-responsive)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267033.2 → NP_001253962.1  myeloid zinc finger 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF055078, BC007777, BC053316
    Consensus CDS
    CCDS59427.1
    UniProtKB/TrEMBL
    M0R1U5
    Related
    ENSP00000469378.1, ENST00000594234.5
    Conserved Domains (2) summary
    smart00431
    Location:40 → 152
    SCAN; leucine rich region
    pfam02023
    Location:40 → 128
    SCAN; SCAN domain

  2. NM_003422.3 → NP_003413.2  myeloid zinc finger 1 isoform 1

    See identical proteins and their annotated locations for NP_003413.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AF055077, BC007777
    Consensus CDS
    CCDS12988.1
    UniProtKB/Swiss-Prot
    M0QXU0, P28698, Q7Z729, Q96I71, Q9NRY0, Q9UBW2
    Related
    ENSP00000469493.1, ENST00000599369.5
    Conserved Domains (4) summary
    smart00431
    Location:40 → 152
    SCAN; leucine rich region
    COG5048
    Location:358 → 716
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:543 → 563
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_198055.2 → NP_932172.1  myeloid zinc finger 1 isoform 1

    See identical proteins and their annotated locations for NP_932172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AF055078, BC007777
    Consensus CDS
    CCDS12988.1
    UniProtKB/Swiss-Prot
    M0QXU0, P28698, Q7Z729, Q96I71, Q9NRY0, Q9UBW2
    Related
    ENSP00000215057.1, ENST00000215057.7
    Conserved Domains (4) summary
    smart00431
    Location:40 → 152
    SCAN; leucine rich region
    COG5048
    Location:358 → 716
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:543 → 563
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58561932..58573573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439312.1 → XP_047295268.1  myeloid zinc finger 1 isoform X1

  2. XM_011527264.4 → XP_011525566.1  myeloid zinc finger 1 isoform X2

    Conserved Domains (7) summary
    smart00431
    Location:70 → 182
    SCAN; leucine rich region
    COG5048
    Location:388 → 746
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:573 → 593
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:472 → 492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:388 → 408
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:70 → 158
    SCAN; SCAN domain
    pfam13465
    Location:697 → 722
    zf-H2C2_2; Zinc-finger double domain

  3. XM_047439313.1 → XP_047295269.1  myeloid zinc finger 1 isoform X1

  4. XM_005259204.4 → XP_005259261.1  myeloid zinc finger 1 isoform X1

    See identical proteins and their annotated locations for XP_005259261.1

    Conserved Domains (4) summary
    smart00431
    Location:81 → 193
    SCAN; leucine rich region
    COG5048
    Location:399 → 757
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:584 → 604
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:483 → 503
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_017027206.2 → XP_016882695.1  myeloid zinc finger 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61659609..61672553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321951.1 → XP_054177926.1  myeloid zinc finger 1 isoform X2

  2. XM_054321948.1 → XP_054177923.1  myeloid zinc finger 1 isoform X1

  3. XM_054321950.1 → XP_054177925.1  myeloid zinc finger 1 isoform X1

  4. XM_054321949.1 → XP_054177924.1  myeloid zinc finger 1 isoform X1

  5. XM_054321952.1 → XP_054177927.1  myeloid zinc finger 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28698.3 GenPept UniProtKB/Swiss-Prot:P28698

Gene LinkOut

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