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cyb5r2 cytochrome b5 reductase 2 [ Danio rerio (zebrafish) ]

Gene ID: 751641, updated on 12-Sep-2024

Summary

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Official Symbol
cyb5r2provided by ZNC
Official Full Name
cytochrome b5 reductase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060825-83
See related
Ensembl:ENSDARG00000051925 AllianceGenome:ZFIN:ZDB-GENE-060825-83
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7147295; zgc:153291
Summary
Predicted to enable FAD binding activity. Acts upstream of or within response to yeast. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human CYB5R2 (cytochrome b5 reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See cyb5r2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (16046615..16057540, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (15950215..15961140, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene PPFIA binding protein 2b Neighboring gene sb:cb470 Neighboring gene ovochymase-2 Neighboring gene fatty acyl CoA reductase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of the proteins required for fatty acid desaturation in zebrafish (Danio rerio). Chen YS, et al. Biochem Biophys Res Commun, 2013 Nov 1. PMID 24103751
  2. Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway. Sun X, et al. Nat Commun, 2020 Jan 24. PMID 31980602, Free PMC Article
  3. Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. Wang YC, et al. BMC Syst Biol, 2013 Aug 16. PMID 23947337, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC153291

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADH-cytochrome b5 reductase 2
Names
b5R.2
NP_001038825.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045360.1 → NP_001038825.1  NADH-cytochrome b5 reductase 2

    See identical proteins and their annotated locations for NP_001038825.1

    Status: PROVISIONAL

    Source sequence(s)
    BC122221
    UniProtKB/Swiss-Prot
    A2CET6, Q0P487
    Related
    ENSDARP00000084821.5, ENSDART00000090388.6
    Conserved Domains (2) summary
    cd06183
    Location:53 → 309
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    PTZ00319
    Location:9 → 309
    PTZ00319; NADH-cytochrome B5 reductase; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    16046615..16057540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P487.2 GenPept UniProtKB/Swiss-Prot:Q0P487

Gene LinkOut

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