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THAPS_264496 aldo-keto oxidoreductase [ Thalassiosira pseudonana CCMP1335 ]

Gene ID: 7442947, updated on 11-Apr-2024

Summary

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Gene symbol
THAPS_264496
Gene description
aldo-keto oxidoreductase
Locus tag
THAPS_264496
Gene type
protein coding
RNA name
aldo-keto oxidoreductase
RefSeq status
PROVISIONAL
Organism
Thalassiosira pseudonana CCMP1335 (strain: CCMP1335)
Lineage
Eukaryota; Stramenopiles; Bacillariophyta; Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales; Thalassiosiraceae; Thalassiosira
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Genomic context

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Location:
chromosome: 18
Exon count:
2
Sequence:
Chromosome: 18; NC_012081.1 (227737..228953)

Chromosome 18 - NC_012081.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hisD, histidinol dehydrogenase Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_012081.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism. Armbrust EV, et al. Science, 2004 Oct 1. PMID 15459382
  2. The Phaeodactylum genome reveals the evolutionary history of diatom genomes. Bowler C, et al. Nature, 2008 Nov 13. PMID 18923393

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables aldose-6-phosphate reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Names
aldo-keto oxidoreductase
XP_002295386.1
  • The aldo-keto reductase family includes a number of related monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase, aldose reductase, prostaglandin F synthase, xylose reductase, rho crystallin, and many others. All possess a similar structure, with a beta-alpha-beta fold characteristic of nucleotide binding proteins. The fold comprises a parallel beta-8/alpha-8-barrel, which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. The hydrophobic nature of the pocket favours aromatic and apolar substrates over highly polar ones.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012081.1 Reference assembly

    Range
    227737..228953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002295350.1 → XP_002295386.1  aldo-keto oxidoreductase [Thalassiosira pseudonana CCMP1335]

    See identical proteins and their annotated locations for XP_002295386.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    B5YLL9
    Conserved Domains (2) summary
    COG0656
    Location:19 → 319
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:51 → 316
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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