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Lonrf3 LON peptidase N-terminal domain and ring finger 3 [ Mus musculus (house mouse) ]

Gene ID: 74365, updated on 14-Nov-2024

Summary

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Official Symbol
Lonrf3provided by MGI
Official Full Name
LON peptidase N-terminal domain and ring finger 3provided by MGI
Primary source
MGI:MGI:1921615
See related
Ensembl:ENSMUSG00000016239 AllianceGenome:MGI:1921615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnf127; 4932412G04Rik; 5730439E01Rik; A830039N02Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be located in cytoplasm. Is expressed in telencephalon mantle layer and telencephalon ventricular layer. Orthologous to human LONRF3 (LON peptidase N-terminal domain and ring finger 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 2.7), placenta adult (RPKM 2.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Lonrf3 in Genome Data Viewer
Location:
X A3.3; X 20.72 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (35592011..35630510)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36328358..36366857)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 42406 Neighboring gene STARR-seq mESC enhancer starr_46996 Neighboring gene zinc finger, CCHC domain containing 12 Neighboring gene predicted gene 6023 Neighboring gene predicted gene, 25047 Neighboring gene predicted gene, 22364 Neighboring gene cancer/testis antigen 47

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  2. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
  3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
LON peptidase N-terminal domain and RING finger protein 3
Names
ring finger protein 127

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028894.1 → NP_083170.1  LON peptidase N-terminal domain and RING finger protein 3

    See identical proteins and their annotated locations for NP_083170.1

    Status: VALIDATED

    Source sequence(s)
    AK016522, AL450395, BC058671, BY740851
    Consensus CDS
    CCDS30059.1
    UniProtKB/Swiss-Prot
    Q9D4H7
    Related
    ENSMUSP00000016383.4, ENSMUST00000016383.10
    Conserved Domains (7) summary
    COG5152
    Location:340 → 498
    COG5152; Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only]
    cd00162
    Location:460 → 499
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl19481
    Location:560 → 746
    LON; Found in ATP-dependent protease La (LON)
    sd00006
    Location:244 → 272
    TPR; TPR repeat [structural motif]
    pfam02190
    Location:549 → 750
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    pfam13414
    Location:243 → 309
    TPR_11; TPR repeat
    pfam14634
    Location:158 → 197
    zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    35592011..35630510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541404.1 → XP_006541467.1  LON peptidase N-terminal domain and RING finger protein 3 isoform X1

    Conserved Domains (6) summary
    COG5574
    Location:456 → 551
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    TIGR00990
    Location:244 → 359
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:244 → 272
    TPR; TPR repeat [structural motif]
    cd16513
    Location:159 → 197
    RING1-HC_LONFs; RING finger 1, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
    cd16514
    Location:510 → 551
    RING2-HC_LONFs; RING finger 2, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
    pfam02190
    Location:601 → 802
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4H7.1 GenPept UniProtKB/Swiss-Prot:Q9D4H7

Gene LinkOut

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