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Abcb6 ATP-binding cassette, sub-family B member 6 [ Mus musculus (house mouse) ]

Gene ID: 74104, updated on 2-Nov-2024

Summary

Official Symbol
Abcb6provided by MGI
Official Full Name
ATP-binding cassette, sub-family B member 6provided by MGI
Primary source
MGI:MGI:1921354
See related
Ensembl:ENSMUSG00000026198 AllianceGenome:MGI:1921354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200005B17Rik
Summary
Enables ABC-type transporter activity. Involved in porphyrin-containing compound metabolic process. Located in endosome and extracellular exosome. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver adult (RPKM 38.1), colon adult (RPKM 25.7) and 28 other tissues See more
Orthologs
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Genomic context

See Abcb6 in Genome Data Viewer
Location:
1 C4; 1 38.62 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75148284..75157066, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75171640..75180392, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene reticulophagy regulator family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1550 Neighboring gene zinc finger, AN1 type domain 2B Neighboring gene STARR-positive B cell enhancer ABC_E8982 Neighboring gene autophagy related 9A Neighboring gene STARR-positive B cell enhancer ABC_E321 Neighboring gene ankyrin repeat and zinc finger domain containing 1 Neighboring gene galactosidase, beta 1-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type heme transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ABC-type heme transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ABC-type heme transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ABC-type transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ABC-type transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ABC-type transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ABC-type transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables tetrapyrrole binding ISO
Inferred from Sequence Orthology
more info
 
enables tetrapyrrole binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular detoxification of cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular detoxification of cadmium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heme metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heme transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in heme transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heme transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heme transport ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular copper ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular copper ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in melanosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in melanosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in porphyrin-containing compound biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in porphyrin-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in porphyrin-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in skin development IEA
Inferred from Electronic Annotation
more info
 
involved_in skin development ISO
Inferred from Sequence Orthology
more info
 
involved_in tetrapyrrole metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in tetrapyrrole metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endolysosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endolysosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in melanosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial envelope ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in multivesicular body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in multivesicular body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ATP-binding cassette sub-family B member 6
Names
ABC-type heme transporter ABCB6
ATP-binding cassette sub-family B member 6, mitochondrial
ATP-binding cassette, sub-family B (MDR/TAP), member 6
NP_076221.1
XP_006496615.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023732.3NP_076221.1  ATP-binding cassette sub-family B member 6

    See identical proteins and their annotated locations for NP_076221.1

    Status: VALIDATED

    Source sequence(s)
    AC166150, AI843102, AK004605, AK151165
    Consensus CDS
    CCDS15065.1
    UniProtKB/Swiss-Prot
    Q3U7N5, Q3UAZ6, Q9DC29
    Related
    ENSMUSP00000027396.9, ENSMUST00000027396.15
    Conserved Domains (4) summary
    cd03253
    Location:590825
    ABCC_ATM1_transporter; ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C
    COG5265
    Location:329823
    ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
    pfam16185
    Location:6255
    MTABC_N; Mitochondrial ABC-transporter N-terminal five TM region
    cl00549
    Location:277544
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75148284..75157066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496552.4XP_006496615.1  ATP-binding cassette sub-family B member 6 isoform X1

    Conserved Domains (1) summary
    COG5265
    Location:41535
    ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]