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atp6v1a.L ATPase H+ transporting V1 subunit A L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 734627, updated on 4-Nov-2024

Summary

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Official Symbol
atp6v1a.L
Official Full Name
ATPase H+ transporting V1 subunit A L homeolog
Primary source
Xenbase:XB-GENE-865279
Locus tag
XELAEV_18011281mg
See related
EnsemblRapid:ENSXLAG00005029167 AllianceGenome:Xenbase:XB-GENE-865279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
v1a; ho68; va68; vma1; vpp2; atp6a1; atpv1a; atp6v1a; atp6v1a1
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and proton transmembrane transporter activity. Predicted to act upstream of or within ATP metabolic process and proton transmembrane transport. Predicted to be located in lysosomal membrane. Predicted to be part of proton-transporting V-type ATPase, V1 domain. Is expressed in dermal system. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See atp6v1a.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
17
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (2599141..2644208)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (2606503..2650630)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene upstream transcription factor family member 3 L homeolog Neighboring gene N(alpha)-acetyltransferase 50, NatE catalytic subunit L homeolog Neighboring gene lamina-associated polypeptide 2 Neighboring gene GRAM domain containing 1C L homeolog Neighboring gene uncharacterized LOC121399793

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC114675

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting V-type ATPase, V1 domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATPase H+ transporting V1 subunit A L homeolog
Names
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A L homeolog
NP_001089571.1
XP_041437033.1
XP_041437034.1
XP_041437035.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096102.1 → NP_001089571.1  ATPase H+ transporting V1 subunit A L homeolog

    See identical proteins and their annotated locations for NP_001089571.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098963
    UniProtKB/TrEMBL
    A0A974DMS2, Q4KLX0
    Conserved Domains (1) summary
    TIGR01042
    Location:17 → 609
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    2599141..2644208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041581100.1 → XP_041437034.1  ATPase H+ transporting V1 subunit A L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974DMS2, Q4KLX0
    Related
    ENSXLAP00005087656.1, ENSXLAT00005089318.1
    Conserved Domains (1) summary
    TIGR01042
    Location:17 → 609
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

  2. XM_041581099.1 → XP_041437033.1  ATPase H+ transporting V1 subunit A L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974DMS2, Q4KLX0
    Related
    ENSXLAP00005087271.1, ENSXLAT00005088933.1
    Conserved Domains (1) summary
    TIGR01042
    Location:17 → 609
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

  3. XM_041581101.1 → XP_041437035.1  ATPase H+ transporting V1 subunit A L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974DMS2, Q4KLX0
    Related
    ENSXLAP00005087354.1, ENSXLAT00005089016.1
    Conserved Domains (1) summary
    TIGR01042
    Location:17 → 609
    V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
Nucleotide Protein Strain
Heading Accession and Version

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