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mtm1.S myotubularin 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 734460, updated on 4-Nov-2024

Summary

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Official Symbol
mtm1.S
Official Full Name
myotubularin 1 S homeolog
Primary source
Xenbase:XB-GENE-6256190
Locus tag
XELAEV_18042185mg
See related
EnsemblRapid:ENSXLAG00005014306 AllianceGenome:Xenbase:XB-GENE-6256190
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
mtm1
Summary
Predicted to enable phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; and phosphoprotein phosphatase activity. Predicted to act upstream of or within several processes, including muscle cell cellular homeostasis; negative regulation of autophagosome assembly; and phosphatidylinositol dephosphorylation. Predicted to be located in several cellular components, including late endosome; ruffle; and sarcomere. Human ortholog(s) of this gene implicated in congenital structural myopathy. Orthologous to human MTM1 (myotubularin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mtm1.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (66398523..66450442)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (64110565..64162493)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 185A S homeolog Neighboring gene mastermind like domain containing 1 S homeolog Neighboring gene myotubularin related protein 1 S homeolog Neighboring gene CD99 molecule like 2 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC115089

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitochondrion distribution IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle cell cellular homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myotubularin
Names
phosphatidylinositol-3,5-bisphosphate 3-phosphatase
phosphatidylinositol-3-phosphate phosphatase
NP_001089410.1
XP_018087605.1
XP_018087606.1
XP_018087608.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095941.1 → NP_001089410.1  myotubularin

    See identical proteins and their annotated locations for NP_001089410.1

    Status: PROVISIONAL

    Source sequence(s)
    BC094184
    UniProtKB/Swiss-Prot
    Q52KU6
    UniProtKB/TrEMBL
    A0A974C3K0
    Related
    ENSXLAP00005041949.1, ENSXLAT00005042995.1
    Conserved Domains (2) summary
    cd13355
    Location:43 → 142
    PH-GRAM_MTM1; Myotubularian 1 protein (MTM1) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam06602
    Location:150 → 482
    Myotub-related; Myotubularin-like phosphatase domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    66398523..66450442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018232119.2 → XP_018087608.2  myotubularin isoform X1

    Conserved Domains (2) summary
    cd13355
    Location:70 → 169
    PH-GRAM_MTM1; Myotubularian 1 protein (MTM1) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd14591
    Location:249 → 497
    PTP-MTM1; protein tyrosine phosphatase-like domain of myotubularin phosphoinositide phosphatase 1

  2. XM_018232116.2 → XP_018087605.1  myotubularin isoform X2

    UniProtKB/Swiss-Prot
    Q52KU6
    UniProtKB/TrEMBL
    A0A974C3K0

  3. XM_018232117.2 → XP_018087606.1  myotubularin isoform X2

    UniProtKB/Swiss-Prot
    Q52KU6
    UniProtKB/TrEMBL
    A0A974C3K0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q52KU6.1 GenPept UniProtKB/Swiss-Prot:Q52KU6

Gene LinkOut

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