ap2a2.L adaptor related protein complex 2 subunit alpha 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ap2a2.L
Official Full Name: adaptor related protein complex 2 subunit alpha 2 L homeolog
Primary source: Xenbase:XB-GENE-865570
Locus tag: XELAEV_18022090mg
See related: EnsemblRapid:ENSXLAG00005018761 AllianceGenome:Xenbase:XB-GENE-865570
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ap2a2
Summary: Predicted to enable clathrin adaptor activity. Predicted to act upstream of or within clathrin-dependent endocytosis and intracellular protein transport. Predicted to be located in clathrin-coated pit. Predicted to be part of AP-2 adaptor complex. Is expressed in ectoderm. Orthologous to human AP2A2 (adaptor related protein complex 2 subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (22213557..22279298, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (20668171..20734048, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within clathrin-dependent endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of membrane coat	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adaptor related protein complex 2 subunit alpha 2 L homeolog

Names: adaptor related protein complex 2 alpha 2 subunit L homeolog; adaptor-related protein complex 2, alpha 2 subunit; alpha-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001095834.1 → NP_001089303.1 adaptor related protein complex 2 subunit alpha 2 L homeolog

See identical proteins and their annotated locations for NP_001089303.1

Status: PROVISIONAL

Source sequence(s)

BC091638

UniProtKB/TrEMBL

A0A974D427, Q5BJ37

Conserved Domains (4) summary

pfam01602
Location:29 → 591

Adaptin_N; Adaptin N terminal region

pfam02296
Location:826 → 934

Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain

pfam02883
Location:713 → 819

Alpha_adaptinC2; Adaptin C-terminal domain

sd00044
Location:332 → 355

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

22213557..22279298 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018256921.2 → XP_018112410.1 adaptor related protein complex 2 subunit alpha 2 L homeolog isoform X3

UniProtKB/TrEMBL

A0A8J0V3H9, A0A974D427

Related

ENSXLAP00005055418.1, ENSXLAT00005056623.1
XM_041589407.1 → XP_041445341.1 adaptor related protein complex 2 subunit alpha 2 L homeolog isoform X2

UniProtKB/TrEMBL

A0A8J1MV71, A0A974D427

Related

ENSXLAP00005055394.1, ENSXLAT00005056599.1

Conserved Domains (3) summary

smart00809
Location:763 → 866

Alpha_adaptinC2; Adaptin C-terminal domain

COG5096
Location:53 → 601

COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]

pfam02296
Location:872 → 980

Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
XM_041589406.1 → XP_041445340.1 adaptor related protein complex 2 subunit alpha 2 L homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1MWG7, A0A974D427

Conserved Domains (4) summary

smart00809
Location:789 → 892

Alpha_adaptinC2; Adaptin C-terminal domain

COG5096
Location:53 → 601

COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]

sd00044
Location:332 → 355

HEAT; HEAT repeat [structural motif]

pfam02296
Location:898 → 1006

Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain