fanca.L FA complementation group A L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: fanca.L
Official Full Name: FA complementation group A L homeolog
Primary source: Xenbase:XB-GENE-1000619
Locus tag: XELAEV_18004708mg
See related: EnsemblRapid:ENSXLAG00005034641 AllianceGenome:Xenbase:XB-GENE-1000619
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: fa1; faa; xFA; faca; fanca; fanch; xfanca
Summary: Predicted to act upstream of or within interstrand cross-link repair. Predicted to be located in membrane. Predicted to be part of Fanconi anaemia nuclear complex. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); acute myeloid leukemia; esophagus squamous cell carcinoma; ovarian disease (multiple); and skin melanoma. Orthologous to human FANCA (FA complementation group A). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 4L

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (52713098..52756136)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694888.1 (45680..88790, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

To understand the basis of the FA-associated FANCA mutations, we determined the cryo-electron microscopy (EM) structures of Xenopus laevis FANCA alone at 3.35 A and 3.46 A resolution and two distinct FANCA-FANCG complexes at 4.59 and 4.84 A resolution, respectively.
Title: Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within interstrand cross-link repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Fanconi anaemia nuclear complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: FA complementation group A L homeolog

Names: Fanconi anemia complementation group A L homeolog; Fanconi anemia, complementation group A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001095690.1 → NP_001089159.1 FA complementation group A L homeolog

See identical proteins and their annotated locations for NP_001089159.1

Status: PROVISIONAL

Source sequence(s)

AY633664

UniProtKB/TrEMBL

A0A974GZP0, Q4VT51

Related

ENSXLAP00005103996.1, ENSXLAT00005106015.1

Conserved Domains (2) summary

pfam03511
Location:1231 → 1289

Fanconi_A; Fanconi anaemia group A protein

pfam15865
Location:164 → 507

Fanconi_A_N; Fanconi anaemia group A protein N terminus