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clcn5 chloride channel, voltage-sensitive 5 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 734069, updated on 4-Nov-2024

Summary

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Official Symbol
clcn5provided by Xenbase
Official Full Name
chloride channel, voltage-sensitive 5provided by Xenbase
Primary source
Xenbase:XB-GENE-5957241
See related
Ensembl:ENSXETG00000002095 AllianceGenome:Xenbase:XB-GENE-5957241
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
ClC-5
Summary
Predicted to enable ATP binding activity and voltage-gated chloride channel activity. Predicted to act upstream of or within chloride transport and transmembrane transport. Predicted to be located in Golgi membrane; endosome membrane; and plasma membrane. Human ortholog(s) of this gene implicated in Dent disease 1; X-linked nephrolithiasis type I; X-linked recessive hypophosphatemic rickets; and low molecular weight proteinuria with hypercalciuric nephrocalcinosis. Orthologous to human CLCN5 (chloride voltage-gated channel 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See clcn5 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
16
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (40060281..40097190)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (18925129..18964267)

Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase Nek6 Neighboring gene gastrula zinc finger protein XlCGF8.2DB-like Neighboring gene cyclin-O protein B Neighboring gene midline 2 Neighboring gene uncharacterized LOC116406766

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
H(+)/Cl(-) exchange transporter 5
Names
chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045745.1 → NP_001039210.1  H(+)/Cl(-) exchange transporter 5

    See identical proteins and their annotated locations for NP_001039210.1

    Status: PROVISIONAL

    Source sequence(s)
    CR942488
    UniProtKB/TrEMBL
    K9J7M1, Q28C29
    Related
    ENSXETP00000080840.1, ENSXETT00000104146.2
    Conserved Domains (2) summary
    cd03684
    Location:127 → 632
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:643 → 793
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    40060281..40097190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012968564.3 → XP_012824018.1  H(+)/Cl(-) exchange transporter 5 isoform X1

    See identical proteins and their annotated locations for XP_012824018.1

    UniProtKB/TrEMBL
    K9J7M1, Q28C29
    Conserved Domains (2) summary
    cd03684
    Location:127 → 632
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:643 → 793
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria

  2. XM_012968566.3 → XP_012824020.1  H(+)/Cl(-) exchange transporter 5 isoform X2

    UniProtKB/TrEMBL
    A0A6I8S600, K9J7M1
    Related
    ENSXETP00000088138.2, ENSXETT00000066884.2
    Conserved Domains (2) summary
    cd03684
    Location:90 → 595
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:606 → 756
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
Nucleotide Protein Strain
Heading Accession and Version

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