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hes5.2.S hairy and enhancer of split 5, gene 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 733286, updated on 4-Nov-2024

Summary

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Official Symbol
hes5.2.S
Official Full Name
hairy and enhancer of split 5, gene 2 S homeolog
Primary source
Xenbase:XB-GENE-6253436
Locus tag
XELAEV_18037484mg
See related
EnsemblRapid:ENSXLAG00005007456 AllianceGenome:Xenbase:XB-GENE-6253436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
esr3; esr7; esr-7; bHLHb38; esr3/7b; hes5.2-a; hes5.2-b
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to act upstream of or within anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; and regulation of neurogenesis. Predicted to be located in nucleus. Orthologous to human HES5 (hes family bHLH transcription factor 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hes5.2.S in Genome Data Viewer
Location:
chromosome: 7S
Exon count:
3
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7S NC_054384.1 (78332234..78334625, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7S NC_030737.1 (59301366..59303757, complement)

Chromosome 7S - NC_054384.1Genomic Context describing neighboring genes Neighboring gene hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) S homeolog Neighboring gene splA/ryanodine receptor domain and SOCS box containing 1 S homeolog Neighboring gene hes family bHLH transcription factor 5 gene 1 S homeolog Neighboring gene pantothenate kinase 4 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of target genes for the Xenopus Hes-related protein XHR1, a prepattern factor specifying the midbrain-hindbrain boundary. Takada H, et al. Dev Biol, 2005 Jul 1. PMID 15935340

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hairy and enhancer of split 5, gene 2 S homeolog
Names
enhancer of split related protein 3/7b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095626.2 → NP_001089095.1  hairy and enhancer of split 5, gene 2 S homeolog

    See identical proteins and their annotated locations for NP_001089095.1

    Status: PROVISIONAL

    Source sequence(s)
    AB211545
    UniProtKB/TrEMBL
    A0A974CDH2, Q53U32
    Related
    ENSXLAP00005021216.1, ENSXLAT00005021882.1
    Conserved Domains (2) summary
    smart00511
    Location:90 → 125
    ORANGE; Orange domain
    cd00083
    Location:16 → 73
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054384.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    78332234..78334625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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