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aldh1a3.L aldehyde dehydrogenase 1 family member A3 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 733178, updated on 4-Nov-2024

Summary

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Official Symbol
aldh1a3.L
Official Full Name
aldehyde dehydrogenase 1 family member A3 L homeolog
Primary source
Xenbase:XB-GENE-992888
Locus tag
XELAEV_18018413mg
See related
AllianceGenome:Xenbase:XB-GENE-992888
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
aldh1a3
Summary
Predicted to enable retinal dehydrogenase activity. Involved in retinoic acid biosynthetic process. Acts upstream of or within anterior/posterior axis specification. Is expressed in appendage; musculoskeletal system; and nervous system. Human ortholog(s) of this gene implicated in isolated microphthalmia 8. Orthologous to human ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aldh1a3.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
13
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (122061253..122092588)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (106650830..106682284)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene lines homolog 1 L homeolog Neighboring gene ankyrin repeat and SOCS box containing 7 L homeolog Neighboring gene leucine-rich repeat kinase 1 L homeolog Neighboring gene uncharacterized LOC108711483

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dorsoventral patterning of the Xenopus eye: a collaboration of Retinoid, Hedgehog and FGF receptor signaling. Lupo G, et al. Development, 2005 Apr. PMID 15753216
  2. Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly. Gur M, et al. Front Cell Dev Biol, 2022. PMID 35372345, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables retinal dehydrogenase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior axis specification IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of head development TAS
Traceable Author Statement
more info
 PubMed 
involved_in retinoic acid biosynthetic process EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within_positive_effect retinoic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinoic acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
aldehyde dehydrogenase 1A3
Names
RALDH3
aldehyde dehydrogenase 1 family, member A3
NP_001089074.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095605.1 → NP_001089074.1  aldehyde dehydrogenase 1A3

    See identical proteins and their annotated locations for NP_001089074.1

    Status: PROVISIONAL

    Source sequence(s)
    AY692028
    UniProtKB/TrEMBL
    A0A974DE78, Q58YE0
    Conserved Domains (1) summary
    cd07141
    Location:26 → 506
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    122061253..122092588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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