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Thap12 THAP domain containing 12 [ Mus musculus (house mouse) ]

Gene ID: 72981, updated on 2-Nov-2024

Summary

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Official Symbol
Thap12provided by MGI
Official Full Name
THAP domain containing 12provided by MGI
Primary source
MGI:MGI:1920231
See related
Ensembl:ENSMUSG00000030753 AllianceGenome:MGI:1920231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dap4; Prkrir; Rpkrir; 2900052B10Rik
Summary
Predicted to enable DNA binding activity; metal ion binding activity; and protein dimerization activity. Located in nucleus. Is expressed in 1st branchial arch; 2nd branchial arch; heart; and trunk. Orthologous to human THAP12 (THAP domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.2), bladder adult (RPKM 15.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Thap12 in Genome Data Viewer
Location:
7 E1; 7 53.86 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (98352254..98367269)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (98703036..98718062)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:105737605-105737906 Neighboring gene EMSY, BRCA2-interacting transcriptional repressor Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:105805164-105805273 Neighboring gene STARR-positive B cell enhancer mm9_chr7:105842676-105842977 Neighboring gene predicted gene 15506 Neighboring gene STARR-positive B cell enhancer ABC_E2833 Neighboring gene predicted gene, 57488 Neighboring gene thymosin, beta 10 pseudogene Neighboring gene predicted gene, 33720

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Zhong X, et al. Proc Natl Acad Sci U S A, 2024 Jul 30. PMID 39047044,
  2. Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. Lin Y, et al. J Biol Chem, 2002 Dec 13. PMID 12384512
  3. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Roussigne M, et al. Trends Biochem Sci, 2003 Feb. PMID 12575992
  4. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article
  5. Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Prescott K, et al. Hum Genet, 2005 May. PMID 15778864

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.
    Title: Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31389

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
52 kDa repressor of the inhibitor of the protein kinase
Names
58 kDa interferon-induced protein kinase-interacting protein
P52rIPK
THAP domain-containing protein 0
THAP domain-containing protein 12
interferon-inducible, double stranded RNA dependent inhibitor, protein-kinase
p58IPK-interacting protein
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355114.1 → NP_001342043.1  52 kDa repressor of the inhibitor of the protein kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC111124
    Conserved Domains (2) summary
    pfam05699
    Location:498 → 555
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam14291
    Location:3 → 155
    DUF4371; Domain of unknown function (DUF4371)

  2. NM_028410.2 → NP_082686.1  52 kDa repressor of the inhibitor of the protein kinase isoform 1

    See identical proteins and their annotated locations for NP_082686.1

    Status: VALIDATED

    Source sequence(s)
    AC111124
    Consensus CDS
    CCDS21474.1
    UniProtKB/Swiss-Prot
    Q80Y58, Q9CUX1
    Related
    ENSMUSP00000033009.10, ENSMUST00000033009.16
    Conserved Domains (3) summary
    pfam05485
    Location:5 → 86
    THAP; THAP domain
    pfam05699
    Location:669 → 726
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam14291
    Location:152 → 326
    DUF4371; Domain of unknown function (DUF4371)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    98352254..98367269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241915.4 → XP_011240217.1  52 kDa repressor of the inhibitor of the protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011240217.1

    UniProtKB/Swiss-Prot
    Q80Y58, Q9CUX1
    Conserved Domains (3) summary
    pfam05485
    Location:5 → 86
    THAP; THAP domain
    pfam05699
    Location:669 → 726
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam14291
    Location:152 → 326
    DUF4371; Domain of unknown function (DUF4371)

  2. XM_036153467.1 → XP_036009360.1  52 kDa repressor of the inhibitor of the protein kinase isoform X2

    Conserved Domains (2) summary
    pfam05699
    Location:498 → 555
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam14291
    Location:3 → 155
    DUF4371; Domain of unknown function (DUF4371)

  3. XM_006508224.5 → XP_006508287.1  52 kDa repressor of the inhibitor of the protein kinase isoform X2

    See identical proteins and their annotated locations for XP_006508287.1

    Conserved Domains (2) summary
    pfam05699
    Location:498 → 555
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    pfam14291
    Location:3 → 155
    DUF4371; Domain of unknown function (DUF4371)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CUX1.2 GenPept UniProtKB/Swiss-Prot:Q9CUX1

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