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Pip4p2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [ Mus musculus (house mouse) ]

Gene ID: 72519, updated on 2-Nov-2024

Summary

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Official Symbol
Pip4p2provided by MGI
Official Full Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2provided by MGI
Primary source
MGI:MGI:1919769
See related
Ensembl:ENSMUSG00000028221 AllianceGenome:MGI:1919769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem55a; 2610319K07Rik
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Involved in negative regulation of phagocytosis and phosphatidylinositol dephosphorylation. Located in late endosome membrane; phagocytic vesicle membrane; and plasma membrane. Orthologous to human PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 23.5), CNS E11.5 (RPKM 19.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pip4p2 in Genome Data Viewer
Location:
4 A1; 4 6.41 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (14864219..14915501)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (14864219..14915260)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 69 Neighboring gene STARR-seq mESC enhancer starr_09637 Neighboring gene STARR-positive B cell enhancer ABC_E6153 Neighboring gene OTU domain containing 6B Neighboring gene predicted gene 11837 Neighboring gene STARR-seq mESC enhancer starr_09640 Neighboring gene N-terminal EF-hand calcium binding protein 1 Neighboring gene predicted gene 11844

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis. Morioka S, et al. J Cell Sci, 2018 Mar 6. PMID 29378918
  2. Ash2l interacts with Tbx1 and is required during early embryogenesis. Stoller JZ, et al. Exp Biol Med (Maywood), 2010 May. PMID 20463296, Free PMC Article
  3. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in phagocytic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Names
ptdIns-4,5-P2 4-Ptase II
transmembrane protein 55A
type 2 PtdIns-4,5-P2 4-Ptase
type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase
NP_001406160.1
NP_082540.1
XP_036020355.1
XP_036020356.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419231.1 → NP_001406160.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL831792

  2. NM_028264.5 → NP_082540.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1

    See identical proteins and their annotated locations for NP_082540.1

    Status: VALIDATED

    Source sequence(s)
    AL831792
    Consensus CDS
    CCDS17981.1
    UniProtKB/Swiss-Prot
    Q9CZX7
    Related
    ENSMUSP00000029875.4, ENSMUST00000029875.4
    Conserved Domains (1) summary
    pfam09788
    Location:7 → 250
    Tmemb_55A; Transmembrane protein 55A

RNA

  1. NR_185048.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831792

  2. NR_185049.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831792

  3. NR_185050.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831792

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    14864219..14915501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164462.1 → XP_036020355.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1

    Conserved Domains (1) summary
    pfam09788
    Location:19 → 147
    Tmemb_55A; Transmembrane protein 55A

  2. XM_036164463.1 → XP_036020356.1  type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1

    Conserved Domains (1) summary
    pfam09788
    Location:19 → 147
    Tmemb_55A; Transmembrane protein 55A
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZX7.1 GenPept UniProtKB/Swiss-Prot:Q9CZX7

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