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TRIO trio Rho guanine nucleotide exchange factor [ Homo sapiens (human) ]

Gene ID: 7204, updated on 14-Nov-2024

Summary

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Official Symbol
TRIOprovided by HGNC
Official Full Name
trio Rho guanine nucleotide exchange factorprovided by HGNC
Primary source
HGNC:HGNC:12303
See related
Ensembl:ENSG00000038382 MIM:601893; AllianceGenome:HGNC:12303
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
tgat; MEBAS; MRD44; MRD63; ARHGEF23
Summary
This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in brain (RPKM 8.0), spleen (RPKM 6.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See TRIO in Genome Data Viewer
Location:
5p15.2
Exon count:
61
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (14143342..14510204)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (14080499..14449245)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (14143451..14510313)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 pseudogene 13 Neighboring gene meiotic recombination hotspot J Neighboring gene dynein axonemal heavy chain 5 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:13858976-13860175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15932 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:14034965-14035492 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:14035876-14037075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:14055383-14055883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15933 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:14108867-14110066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14118635-14119191 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14119192-14119747 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:14125559-14126060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15939 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22387 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22388 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14174256-14174781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22396 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:14254265-14254435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22399 Neighboring gene Sharpr-MPRA regulatory region 5150 Neighboring gene uncharacterized LOC124900943 Neighboring gene OCT4 hESC enhancer GRCh37_chr5:14346974-14347475 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14358109-14358798 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:14399912-14401111 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:14406263-14407462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14417547-14418093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14445485-14446012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:14446013-14446539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22403 Neighboring gene Sharpr-MPRA regulatory region 14564 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:14465686-14465857 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:14497716-14498915 Neighboring gene small nucleolar RNA, C/D box 170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:14521506-14522006 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:14522007-14522507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:14577633-14578133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15941 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22406 Neighboring gene pleckstrin homology domain containing A1 pseudogene Neighboring gene OTU deubiquitinase with linear linkage specificity like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation. van Rijssel J, et al. Mol Biol Cell, 2012 Aug. PMID 22696684, Free PMC Article
  2. Novel loss-of-function variants in TRIO are associated with neurodevelopmental disorder: case report. Schultz-Rogers L, et al. BMC Med Genet, 2020 Nov 10. PMID 33167890, Free PMC Article
  3. Genetics of physiological dysregulation: findings from the long life family study using joint models. Arbeev KG, et al. Aging (Albany NY), 2020 Apr 1. PMID 32235003, Free PMC Article
  4. More evidence on TRIO missense mutations in the spectrin repeat domain causing severe developmental delay and recognizable facial dysmorphism with macrocephaly. Kloth K, et al. Neurogenetics, 2021 Jul. PMID 34013494
  5. The Role of Trio, a Rho Guanine Nucleotide Exchange Factor, in Glomerular Podocytes. Maier M, et al. Int J Mol Sci, 2018 Feb 6. PMID 29415466, Free PMC Article

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Detection of autism spectrum disorder-related pathogenic trio variants by a novel structure-based approach.
    Title: Detection of autism spectrum disorder-related pathogenic trio variants by a novel structure-based approach.
  2. Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo.
    Title: Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo.
  3. Autoinhibition of the GEF activity of cytoskeletal regulatory protein Trio is disrupted in neurodevelopmental disorder-related genetic variants.
    Title: Autoinhibition of the GEF activity of cytoskeletal regulatory protein Trio is disrupted in neurodevelopmental disorder-related genetic variants.
  4. Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.
    Title: Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.
  5. Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA.
    Title: Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA.
  6. More evidence on TRIO missense mutations in the spectrin repeat domain causing severe developmental delay and recognizable facial dysmorphism with macrocephaly.
    Title: More evidence on TRIO missense mutations in the spectrin repeat domain causing severe developmental delay and recognizable facial dysmorphism with macrocephaly.
  7. Complex interactions between the angiotensin II type 1 receptor, the epidermal growth factor receptor and TRIO-dependent signaling partners.
    Title: Complex interactions between the angiotensin II type 1 receptor, the epidermal growth factor receptor and TRIO-dependent signaling partners.
  8. Genetics of physiological dysregulation: findings from the long life family study using joint models.
    Title: Genetics of physiological dysregulation: findings from the long life family study using joint models.
  9. Novel loss-of-function variants in TRIO are associated with neurodevelopmental disorder: case report.
    Title: Novel loss-of-function variants in TRIO are associated with neurodevelopmental disorder: case report.
  10. The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled.
    Title: The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2018-01-24)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2018-01-24)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
EBI GWAS Catalog
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42780

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine phosphatase signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
triple functional domain protein
Names
PTPRF-interacting protein
triple functional domain (PTPRF interacting)
NP_009049.2
XP_011512409.1
XP_011512410.1
XP_011512411.1
XP_011512412.1
XP_016865290.1
XP_016865291.1
XP_016865292.1
XP_047273635.1
XP_047273637.1
XP_054209360.1
XP_054209361.1
XP_054209362.1
XP_054209363.1
XP_054209364.1
XP_054209365.1
XP_054209366.1
XP_054209367.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052962.1 RefSeqGene

    Range
    4641..371503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007118.4 → NP_009049.2  triple functional domain protein

    See identical proteins and their annotated locations for NP_009049.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AC010419, AF091395, AI478154, AK131423, BC017268, BC035585, BF058117, BQ184284, BQ691537, U42390
    Consensus CDS
    CCDS3883.1
    UniProtKB/Swiss-Prot
    D3DTD1, O75962, Q13458, Q59EQ7, Q6PJC9, Q6ZN05, Q8IWK8
    UniProtKB/TrEMBL
    A0A2X0SFJ0
    Related
    ENSP00000339299.4, ENST00000344204.9
    Conserved Domains (14) summary
    smart00150
    Location:1143 → 1243
    SPEC; Spectrin repeats
    cd11852
    Location:1659 → 1718
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2555 → 2613
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2796 → 3050
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:69 → 204
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1970 → 2143
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:567 → 783
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2685 → 2776
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1472 → 1594
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2148 → 2286
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:2788 → 3050
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam00169
    Location:2175 → 2271
    PH; PH domain
    pfam16609
    Location:1715 → 1972
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl11960
    Location:2699 → 2776
    Ig; Immunoglobulin domain

RNA

  1. NR_134469.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010419, AF091395, AI478154, AK131423, BC017268, BC035585, BF058117, BQ184284, BQ691537, U42390
    Related
    ENST00000512070.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    14143342..14510204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417679.1 → XP_047273635.1  triple functional domain protein isoform X2

  2. XM_017009802.2 → XP_016865291.1  triple functional domain protein isoform X6

    UniProtKB/TrEMBL
    A0A2X0SFJ0
    Related
    ENSP00000426342.2, ENST00000513206.5

  3. XM_017009801.2 → XP_016865290.1  triple functional domain protein isoform X1

    UniProtKB/TrEMBL
    A0A2X0SFJ0

  4. XM_047417681.1 → XP_047273637.1  triple functional domain protein isoform X7

  5. XM_011514110.4 → XP_011512412.1  triple functional domain protein isoform X5

    See identical proteins and their annotated locations for XP_011512412.1

    UniProtKB/TrEMBL
    A0A2X0SFJ0
    Conserved Domains (14) summary
    smart00150
    Location:1084 → 1184
    SPEC; Spectrin repeats
    cd11852
    Location:1600 → 1659
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2496 → 2554
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2737 → 2991
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:10 → 145
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1911 → 2084
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:508 → 724
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2626 → 2717
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1413 → 1535
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2089 → 2227
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:2729 → 2991
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam00169
    Location:2116 → 2212
    PH; PH domain
    pfam16609
    Location:1656 → 1913
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl11960
    Location:2640 → 2717
    Ig; Immunoglobulin domain

  6. XM_011514108.2 → XP_011512410.1  triple functional domain protein isoform X3

    UniProtKB/TrEMBL
    A0A2X0SFJ0
    Conserved Domains (14) summary
    smart00150
    Location:1104 → 1204
    SPEC; Spectrin repeats
    cd11852
    Location:1620 → 1679
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2516 → 2574
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2757 → 3011
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:30 → 165
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1931 → 2104
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:528 → 744
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2646 → 2737
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1433 → 1555
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:2749 → 3011
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam00169
    Location:2136 → 2232
    PH; PH domain
    pfam16609
    Location:1676 → 1933
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl11960
    Location:2660 → 2737
    Ig; Immunoglobulin domain

  7. XM_011514109.4 → XP_011512411.1  triple functional domain protein isoform X4

    UniProtKB/TrEMBL
    A0A2X0SFJ0
    Conserved Domains (14) summary
    smart00150
    Location:1094 → 1194
    SPEC; Spectrin repeats
    cd11852
    Location:1610 → 1669
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2506 → 2564
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2747 → 3001
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:20 → 155
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1921 → 2094
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:518 → 734
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2636 → 2727
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1423 → 1545
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2099 → 2237
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:2739 → 3001
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam00169
    Location:2126 → 2222
    PH; PH domain
    pfam16609
    Location:1666 → 1923
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl11960
    Location:2650 → 2727
    Ig; Immunoglobulin domain

  8. XM_011514107.3 → XP_011512409.1  triple functional domain protein isoform X2

    UniProtKB/TrEMBL
    A0A2X0SFJ0
    Conserved Domains (14) summary
    smart00150
    Location:1122 → 1222
    SPEC; Spectrin repeats
    cd11852
    Location:1638 → 1697
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2534 → 2592
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2775 → 3029
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:48 → 183
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1949 → 2122
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:546 → 762
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2664 → 2755
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1451 → 1573
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2127 → 2265
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:2767 → 3029
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam00169
    Location:2154 → 2250
    PH; PH domain
    pfam16609
    Location:1694 → 1951
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl11960
    Location:2678 → 2755
    Ig; Immunoglobulin domain

  9. XM_017009803.2 → XP_016865292.1  triple functional domain protein isoform X8

    UniProtKB/TrEMBL
    A0A2X0SFJ0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    14080499..14449245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353386.1 → XP_054209361.1  triple functional domain protein isoform X2

  2. XM_054353390.1 → XP_054209365.1  triple functional domain protein isoform X6

  3. XM_054353385.1 → XP_054209360.1  triple functional domain protein isoform X1

  4. XM_054353391.1 → XP_054209366.1  triple functional domain protein isoform X7

  5. XM_054353389.1 → XP_054209364.1  triple functional domain protein isoform X5

  6. XM_054353387.1 → XP_054209362.1  triple functional domain protein isoform X3

  7. XM_054353388.1 → XP_054209363.1  triple functional domain protein isoform X4

  8. XM_054353392.1 → XP_054209367.1  triple functional domain protein isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75962.2 GenPept UniProtKB/Swiss-Prot:O75962

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