PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: PIK3R2provided by VGNC
Official Full Name: phosphoinositide-3-kinase regulatory subunit 2provided by VGNC
Primary source: VGNC:VGNC:112021
See related: Ensembl:ENSMMUG00000003162
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	19	NC_041772.1 (17676293..17695959)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	19	NC_027911.1 (18155660..18174858)

Chromosome 19 - NC_041772.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that microRNA-126 plays role in diabetic retinopathy; here, choroid-retinal endothelial cells exposed to high glucose exhibit down-regulation of microRNA-126 and up-regulation of VEGFA and PIK3R2; overexpression of microRNA-126 down-regulates expression of VEGFA and PIK3R2. (VEGFA = vascular endothelial growth factor A; PIK3R2 = class Ia phosphoinositol-3 kinase regulatory subunit 2)
Title: MiR-126 overexpression inhibits high glucose-induced migration and tube formation of rhesus macaque choroid-retinal endothelial cells by obstructing VEGFA and PIK3R2.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 3-kinase regulatory subunit beta

Names: phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001258052.1 → NP_001244981.1 phosphatidylinositol 3-kinase regulatory subunit beta

See identical proteins and their annotated locations for NP_001244981.1

Status: PROVISIONAL

Source sequence(s)

JU476014

UniProtKB/TrEMBL

F7EP57, H9FVU8, H9ZA52

Related

ENSMMUP00000004228.4, ENSMMUT00000004480.4

Conserved Domains (5) summary

cd09930
Location:614 → 716

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:321 → 431

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd11909
Location:7 → 80

SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases

cd12926
Location:436 → 596

iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta

cd04388
Location:110 → 295

RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041772.1 Reference Mmul_10 Primary Assembly

Range

17676293..17695959

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015123291.2 → XP_014978777.1 phosphatidylinositol 3-kinase regulatory subunit beta isoform X1

UniProtKB/TrEMBL

F7EP57, H9FVU8, H9ZA52

Conserved Domains (5) summary

cd09930
Location:614 → 716

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:321 → 431

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd11909
Location:7 → 80

SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases

cd12926
Location:436 → 596

iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta

cd04388
Location:110 → 295

RhoGAP_p85; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) ...