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TRAF3 TNF receptor associated factor 3 [ Homo sapiens (human) ]

Gene ID: 7187, updated on 14-Nov-2024

Summary

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Official Symbol
TRAF3provided by HGNC
Official Full Name
TNF receptor associated factor 3provided by HGNC
Primary source
HGNC:HGNC:12033
See related
Ensembl:ENSG00000131323 MIM:601896; AllianceGenome:HGNC:12033
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP1; LAP1; CAP-1; CRAF1; IIAE5; CD40bp; RNF118
Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in lymph node (RPKM 5.0), appendix (RPKM 4.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See TRAF3 in Genome Data Viewer
Location:
14q32.32
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102777449..102911500)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97013797..97147747)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103243786..103377837)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene REST corepressor 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103129073-103129810 Neighboring gene ribosomal protein L23a pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9077 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:103174038-103175237 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:103188411-103189610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103204471-103204972 Neighboring gene uncharacterized LOC124903390 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103213106-103213279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103216089-103216923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103224133-103224633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103236826-103237330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103237331-103237835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6130 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6131 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103249335-103249487 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9085 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103276021-103276180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103294403-103294902 Neighboring gene NANOG hESC enhancer GRCh37_chr14:103307110-103307650 Neighboring gene RNA, U6 small nuclear 1316, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:103352003-103353202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103357046-103357546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103357547-103358047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103366521-103367022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103367023-103367522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103379429-103380018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103380019-103380608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103380952-103381452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6134 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103390587-103390785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6136 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:103411482-103412681 Neighboring gene CDC42 binding protein kinase beta Neighboring gene amnion associated transmembrane protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103452779-103453413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103453414-103454047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103464738-103465284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9093 Neighboring gene Sharpr-MPRA regulatory region 6354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103486267-103486822 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103489632-103489899 Neighboring gene Sharpr-MPRA regulatory region 14595 Neighboring gene ribosomal protein L13 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRAF3 loss-of-function reveals the noncanonical NF-kappaB pathway as a therapeutic target in diffuse large B cell lymphoma.
    Title: TRAF3 loss-of-function reveals the noncanonical NF-κB pathway as a therapeutic target in diffuse large B cell lymphoma.
  2. FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3.
    Title: FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3.
  3. The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-beta1-induced BEAS-2B Cell Injury.
    Title: The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-β1-induced BEAS-2B Cell Injury.
  4. Effects of TRAF3 on the proliferation and migration of lung adenocarcinoma depend partly on pyroptosis.
    Title: Effects of TRAF3 on the proliferation and migration of lung adenocarcinoma depend partly on pyroptosis.
  5. TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses.
    Title: TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses.
  6. Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis.
    Title: Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis.
  7. LncRNA XIST Exacerbates Oxygen-Glucose Deprivation/Reoxygenation-Induced Cerebral Injury Through the miR-25-3p/TRAF3 Axis.
    Title: LncRNA XIST Exacerbates Oxygen-Glucose Deprivation/Reoxygenation-Induced Cerebral Injury Through the miR-25-3p/TRAF3 Axis.
  8. TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
    Title: TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
  9. Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.
    Title: Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations.
  10. Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury.
    Title: Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury.
Submit: New GeneRIF Correction See all GeneRIFs (140)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Herpes simplex encephalitis, susceptibility to, 3
MedGen: C3553868 OMIM: 614849 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells PubMed
tat HIV-1 Tat-induced upregulation of microRNA 32 results in downregulation of TRAF3 in human microglial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioesterase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in Toll signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of CD40 receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IC
Inferred by Curator
more info
 PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of serine/threonine protein kinase complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
TNF receptor-associated factor 3
Names
CD40 associated protein 1
CD40 binding protein
CD40 receptor associated factor 1
LMP1-associated protein 1
RING-type E3 ubiquitin transferase TRAF3
NP_001186356.1
NP_001372071.1
NP_001372072.1
NP_003291.2
NP_663777.1
NP_663778.1
XP_011535418.1
XP_011535419.1
XP_011535420.1
XP_016877106.1
XP_016877107.1
XP_016877108.1
XP_016877109.1
XP_047287694.1
XP_047287695.1
XP_047287696.1
XP_047287697.1
XP_047287698.1
XP_054232638.1
XP_054232639.1
XP_054232640.1
XP_054232641.1
XP_054232642.1
XP_054232643.1
XP_054232644.1
XP_054232645.1
XP_054232646.1
XP_054232647.1
XP_054232648.1
XP_054232649.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027973.1 RefSeqGene

    Range
    5001..139022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_229

mRNA and Protein(s)

  1. NM_001199427.2 → NP_001186356.1  TNF receptor-associated factor 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame coding segment compared to variant 1. The resulting isoform (2) lacks an internal region as compared to isoform 1.
    Source sequence(s)
    AK303172, AL117209, AL132801, BQ000015, U21092
    Consensus CDS
    CCDS55946.1
    UniProtKB/Swiss-Prot
    Q13114
    Related
    ENSP00000445998.1, ENST00000539721.5
    Conserved Domains (4) summary
    smart00184
    Location:53 → 88
    RING; Ring finger
    cd03777
    Location:295 → 480
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:136 → 190
    zf-TRAF; TRAF-type zinc finger
    pfam17082
    Location:224 → 283
    Spc29; Spindle Pole Component 29

  2. NM_001385142.1 → NP_001372071.1  TNF receptor-associated factor 3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL117209, AL132801
    Conserved Domains (4) summary
    cd03777
    Location:331 → 516
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:136 → 192
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:51 → 92
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    cl40617
    Location:197 → 247
    zf-TRAF; TRAF-type zinc finger

  3. NM_001385143.1 → NP_001372072.1  TNF receptor-associated factor 3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL117209, AL132801
    Related
    ENST00000699895.1
    Conserved Domains (4) summary
    COG1196
    Location:225 → 406
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03777
    Location:351 → 536
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:136 → 190
    zf-TRAF; TRAF-type zinc finger
    cd16640
    Location:51 → 92
    RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

  4. NM_003300.4 → NP_003291.2  TNF receptor-associated factor 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL117209, AL132801, BQ000015, BX247977, U21092
    Consensus CDS
    CCDS9975.1
    UniProtKB/Swiss-Prot
    B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
    Related
    ENSP00000454207.1, ENST00000560371.5
    Conserved Domains (5) summary
    cd03777
    Location:378 → 563
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam00097
    Location:56 → 91
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:136 → 192
    zf-TRAF; TRAF-type zinc finger
    pfam15272
    Location:263 → 321
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17082
    Location:307 → 366
    Spc29; Spindle Pole Component 29

  5. NM_145725.3 → NP_663777.1  TNF receptor-associated factor 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL117209, AL132801, BQ000015, BX247977, U21092
    Consensus CDS
    CCDS9975.1
    UniProtKB/Swiss-Prot
    B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
    Related
    ENSP00000376500.3, ENST00000392745.8
    Conserved Domains (5) summary
    cd03777
    Location:378 → 563
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam00097
    Location:56 → 91
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:136 → 192
    zf-TRAF; TRAF-type zinc finger
    pfam15272
    Location:263 → 321
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17082
    Location:307 → 366
    Spc29; Spindle Pole Component 29

  6. NM_145726.3 → NP_663778.1  TNF receptor-associated factor 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding segment compared to variant 1. The resulting isoform (2) lacks an internal region compared to isoform 1.
    Source sequence(s)
    AL117209, AL132801, BQ000015, BX247977, U21092
    Consensus CDS
    CCDS9976.1
    UniProtKB/TrEMBL
    A6NHG8
    Related
    ENSP00000332468.5, ENST00000351691.10
    Conserved Domains (4) summary
    cd03777
    Location:353 → 538
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    TIGR04527
    Location:235 → 361
    mycoplas_twoTM; two transmembrane protein
    pfam00097
    Location:56 → 91
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:136 → 192
    zf-TRAF; TRAF-type zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    102777449..102911500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537117.4 → XP_011535419.1  TNF receptor-associated factor 3 isoform X4

    Conserved Domains (4) summary
    cd03777
    Location:322 → 507
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam00097
    Location:56 → 91
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:136 → 192
    zf-TRAF; TRAF-type zinc finger
    pfam17082
    Location:251 → 310
    Spc29; Spindle Pole Component 29

  2. XM_011537116.4 → XP_011535418.1  TNF receptor-associated factor 3 isoform X3

    Conserved Domains (4) summary
    smart00184
    Location:53 → 88
    RING; Ring finger
    cd03777
    Location:326 → 511
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    TIGR04527
    Location:208 → 334
    mycoplas_twoTM; two transmembrane protein
    pfam02176
    Location:136 → 190
    zf-TRAF; TRAF-type zinc finger

  3. XM_011537118.4 → XP_011535420.1  TNF receptor-associated factor 3 isoform X5

    UniProtKB/Swiss-Prot
    Q13114
    Conserved Domains (4) summary
    smart00184
    Location:53 → 88
    RING; Ring finger
    cd03777
    Location:295 → 480
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:136 → 190
    zf-TRAF; TRAF-type zinc finger
    pfam17082
    Location:224 → 283
    Spc29; Spindle Pole Component 29

  4. XM_047431739.1 → XP_047287695.1  TNF receptor-associated factor 3 isoform X2

    UniProtKB/TrEMBL
    A6NHG8

  5. XM_047431742.1 → XP_047287698.1  TNF receptor-associated factor 3 isoform X4

  6. XM_047431740.1 → XP_047287696.1  TNF receptor-associated factor 3 isoform X3

  7. XM_017021620.3 → XP_016877109.1  TNF receptor-associated factor 3 isoform X6

  8. XM_017021617.2 → XP_016877106.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/Swiss-Prot
    B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
    Conserved Domains (5) summary
    cd03777
    Location:378 → 563
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam00097
    Location:56 → 91
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:136 → 192
    zf-TRAF; TRAF-type zinc finger
    pfam15272
    Location:263 → 321
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17082
    Location:307 → 366
    Spc29; Spindle Pole Component 29

  9. XM_047431738.1 → XP_047287694.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/Swiss-Prot
    B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1

  10. XM_017021618.2 → XP_016877107.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/Swiss-Prot
    B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
    Related
    ENSP00000514678.1, ENST00000699894.1
    Conserved Domains (5) summary
    cd03777
    Location:378 → 563
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam00097
    Location:56 → 91
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:136 → 192
    zf-TRAF; TRAF-type zinc finger
    pfam15272
    Location:263 → 321
    BBP1_C; Spindle pole body component BBP1, C-terminal
    pfam17082
    Location:307 → 366
    Spc29; Spindle Pole Component 29

  11. XM_017021619.2 → XP_016877108.1  TNF receptor-associated factor 3 isoform X2

    UniProtKB/TrEMBL
    A6NHG8
    Related
    ENSP00000514677.1, ENST00000699893.1
    Conserved Domains (4) summary
    cd03777
    Location:353 → 538
    MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    TIGR04527
    Location:235 → 361
    mycoplas_twoTM; two transmembrane protein
    pfam00097
    Location:56 → 91
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:136 → 192
    zf-TRAF; TRAF-type zinc finger

  12. XM_047431741.1 → XP_047287697.1  TNF receptor-associated factor 3 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    97013797..97147747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376670.1 → XP_054232645.1  TNF receptor-associated factor 3 isoform X4

  2. XM_054376668.1 → XP_054232643.1  TNF receptor-associated factor 3 isoform X3

  3. XM_054376673.1 → XP_054232648.1  TNF receptor-associated factor 3 isoform X5

  4. XM_054376667.1 → XP_054232642.1  TNF receptor-associated factor 3 isoform X2

    UniProtKB/TrEMBL
    A6NHG8

  5. XM_054376672.1 → XP_054232647.1  TNF receptor-associated factor 3 isoform X4

  6. XM_054376669.1 → XP_054232644.1  TNF receptor-associated factor 3 isoform X3

  7. XM_054376674.1 → XP_054232649.1  TNF receptor-associated factor 3 isoform X6

  8. XM_054376664.1 → XP_054232639.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/Swiss-Prot
    B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1

  9. XM_054376665.1 → XP_054232640.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/Swiss-Prot
    B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1

  10. XM_054376666.1 → XP_054232641.1  TNF receptor-associated factor 3 isoform X2

    UniProtKB/TrEMBL
    A6NHG8

  11. XM_054376671.1 → XP_054232646.1  TNF receptor-associated factor 3 isoform X4

  12. XM_054376663.1 → XP_054232638.1  TNF receptor-associated factor 3 isoform X1

    UniProtKB/Swiss-Prot
    B7Z8C4, Q12990, Q13076, Q13114, Q13947, Q6AZX1, Q9UNL1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13114.2 GenPept UniProtKB/Swiss-Prot:Q13114

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