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TPM1 tropomyosin 1 [ Homo sapiens (human) ]

Gene ID: 7168, updated on 3-Nov-2024

Summary

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Official Symbol
TPM1provided by HGNC
Official Full Name
tropomyosin 1provided by HGNC
Primary source
HGNC:HGNC:12010
See related
Ensembl:ENSG00000140416 MIM:191010; AllianceGenome:HGNC:12010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha
Summary
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022]
Expression
Biased expression in heart (RPKM 615.8), prostate (RPKM 140.5) and 9 other tissues See more
Orthologs
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Genomic context

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See TPM1 in Genome Data Viewer
Location:
15q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (63042747..63071915)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (60846575..60875760)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (63334946..63364114)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene talin 2 Neighboring gene uncharacterized LOC105370854 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:63126856-63128055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63137585-63138085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63138767-63139268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63139269-63139768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63167575-63168413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63189794-63190559 Neighboring gene Y-box-binding protein 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:63253469-63253969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63281148-63281648 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63281649-63282149 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63333890-63334804 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:63335718-63336631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63370949-63371626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:63371627-63372302 Neighboring gene VISTA enhancer hs2160 Neighboring gene TPM1 antisense RNA Neighboring gene Sharpr-MPRA regulatory region 14461 Neighboring gene uncharacterized LOC107984798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6509 Neighboring gene lactamase beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end. Racca AW, et al. J Biol Chem, 2020 Dec 11. PMID 33020181, Free PMC Article
  2. Association of single nucleotide polymorphisms in the 3'UTR region of TPM1 gene with dilated cardiomyopathy: A case-control study. Yao Q, et al. Medicine (Baltimore), 2019 Nov. PMID 31689804, Free PMC Article
  3. Facilitated cross-bridge interactions with thin filaments by familial hypertrophic cardiomyopathy mutations in α-tropomyosin. Wang F, et al. J Biomed Biotechnol, 2011. PMID 22187526, Free PMC Article
  4. TPM1 is a Novel Predictive Biomarker for Gastric Cancer Diagnosis and Prognosis. Hu L, et al. Clin Lab, 2020 Apr 1. PMID 32255282
  5. Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy. Kuusisto J, et al. Heart, 2012 Jul. PMID 22447464, Free PMC Article

See all (305) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin.
    Title: Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin.
  2. MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1.
    Title: MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1.
  3. Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability.
    Title: Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability.
  4. The prognostic value of TPM1-4 in hepatocellular carcinoma.
    Title: The prognostic value of TPM1-4 in hepatocellular carcinoma.
  5. Genotype-phenotype correlations in hypertrophic cardiomyopathy: a multicenter study in Portugal and Spain of the TPM1 p.Arg21Leu variant.
    Title: Genotype-phenotype correlations in hypertrophic cardiomyopathy: a multicenter study in Portugal and Spain of the TPM1 p.Arg21Leu variant.
  6. Identification of a novel missense mutation in the TPM1 gene via exome sequencing in a Chinese family with dilated cardiomyopathy: A case report and literature review.
    Title: Identification of a novel missense mutation in the TPM1 gene via exome sequencing in a Chinese family with dilated cardiomyopathy: A case report and literature review.
  7. The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ.
    Title: The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ.
  8. Association Between TPM1 Gene Polymorphisms and Idiopathic Congenital Talipes Equinovarus Risk in a Chinese Population.
    Title: Association Between TPM1 Gene Polymorphisms and Idiopathic Congenital Talipes Equinovarus Risk in a Chinese Population.
  9. Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation.
    Title: Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation.
  10. Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558.
    Title: Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558.
Submit: New GeneRIF Correction See all GeneRIFs (120)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in TPM1 that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Associated conditions

Description Tests
Dilated cardiomyopathy 1Y
MedGen: C2678476 OMIM: 611878 GeneReviews: Dilated Cardiomyopathy Overview
not available
Hypertrophic cardiomyopathy 3
MedGen: C1861863 OMIM: 115196 GeneReviews: Hypertrophic Cardiomyopathy Overview
not available
Primary dilated cardiomyopathy
MedGen: C0007193 GeneReviews: Dilated Cardiomyopathy Overview
not available

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2015-11-09)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2015-11-09)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
EBI GWAS Catalog
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
EBI GWAS Catalog
New gene functions in megakaryopoiesis and platelet formation.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Exposure of human skin fibroblasts to HIV-1 protease induces the degradation of the vimentin filament network and the disappearance of the tropomyosin isoforms microfilament network PubMed
gag-pol HIV-1 protease cleaves tropomyosin in vitro at positions 30, 51, and 87 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding TAS
Traceable Author Statement
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
enables structural constituent of muscle TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to reactive oxygen species IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in muscle filament sliding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ATP-dependent activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of heart rate by epinephrine ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of heart contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in ruffle organization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bleb IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of muscle thin filament tropomyosin TAS
Traceable Author Statement
more info
 PubMed 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcomere TAS
Traceable Author Statement
more info
 PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tropomyosin alpha-1 chain
Names
cardiomyopathy, hypertrophic 3
epididymis secretory protein Li 265
sarcomeric tropomyosin kappa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007557.1 RefSeqGene

    Range
    5109..28540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_387

mRNA and Protein(s)

  1. NM_000366.6 → NP_000357.3  tropomyosin alpha-1 chain isoform Tpm1.5cy

    See identical proteins and their annotated locations for NP_000357.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.5, also known as variant 5) contains an alternate, in-frame exon and uses an alternate in-frame splice site and upstream stop codon, compared to variant Tpm1.1. It encodes isoform Tpm1.5cy, which has a different C-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, BC007433, BG107949, CN423344
    Consensus CDS
    CCDS10181.1
    UniProtKB/TrEMBL
    A0A0K0K1I0
    Related
    ENSP00000288398.6, ENST00000288398.10
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  2. NM_001018004.2 → NP_001018004.1  tropomyosin alpha-1 chain isoform Tpm1.6cy

    See identical proteins and their annotated locations for NP_001018004.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.6, also known as variant 3) contains an alternate, in-frame exon in the 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.6cy, also known as the TM-2 fibroblast isoform, which has a distinct C-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AJ000147
    Consensus CDS
    CCDS58369.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    O15513
    Related
    ENSP00000453941.1, ENST00000559556.5
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  3. NM_001018005.2 → NP_001018005.1  tropomyosin alpha-1 chain isoform Tpm1.1st

    See identical proteins and their annotated locations for NP_001018005.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.1, also known as variant 1) represents the shortest transcript. It encodes the longest isoform (Tpm1.1st), also known as the fast skeletal muscle isoform.
    Source sequence(s)
    AC079328, BC007433, BG107949, M19713
    Consensus CDS
    CCDS45273.1
    UniProtKB/Swiss-Prot
    B7Z5T7, D9YZV2, D9YZV3, D9YZV8, P09493, P09494, P10469, Q6DV89, Q6DV90, Q7Z6L8, Q86W64, Q96IK2, Q9UCI1, Q9UCI2, Q9UCY9, Q9Y427
    UniProtKB/TrEMBL
    A0AAQ5BH79, D9YZV4
    Related
    ENSP00000385107.4, ENST00000403994.9
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  4. NM_001018006.2 → NP_001018006.1  tropomyosin alpha-1 chain isoform Tpm1.7cy

    See identical proteins and their annotated locations for NP_001018006.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.7, also known as variant 4) contains alternate, in-frame exons in the 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.7cy, also known as the TM-3 fibroblast isoform, which has a distinct C-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AJ000147
    Consensus CDS
    CCDS32263.1
    UniProtKB/TrEMBL
    D9YZV5
    Related
    ENSP00000351022.3, ENST00000358278.7
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  5. NM_001018007.2 → NP_001018007.1  tropomyosin alpha-1 chain isoform Tpm1.4sm

    See identical proteins and their annotated locations for NP_001018007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.4, also known as variant 2) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.4sm, also known as the smooth muscle isoform, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
    Source sequence(s)
    AL050179, BG107949
    Consensus CDS
    CCDS32262.1
    Related
    ENSP00000267996.7, ENST00000267996.11
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  6. NM_001018008.2 → NP_001018008.1  tropomyosin alpha-1 chain isoform Tpm1.12br

    See identical proteins and their annotated locations for NP_001018008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.12, also known as variant 6) contains alternate in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.12br, also known as the TMBr-3 brain isoform, which has distinct N- and C-termini and is shorter than isoform Tpm1.1st.
    Source sequence(s)
    AC079328, BC050473, BC053545
    Consensus CDS
    CCDS32264.1
    UniProtKB/TrEMBL
    D9YZV7, Q59GR8
    Related
    ENSP00000334624.4, ENST00000334895.10
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 244
    Tropomyosin

  7. NM_001018020.2 → NP_001018020.1  tropomyosin alpha-1 chain isoform Tpm1.3sm

    See identical proteins and their annotated locations for NP_001018020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.3, also known as variant 7) contains alternate, in-frame exons in the coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.3sm, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AJ000147, BG107949, BX458841
    Consensus CDS
    CCDS58368.1
    UniProtKB/Swiss-Prot
    P09493
    UniProtKB/TrEMBL
    O15513
    Related
    ENSP00000452879.1, ENST00000559397.6
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  8. NM_001301244.2 → NP_001288173.1  tropomyosin alpha-1 chain isoform Tpm1.2st

    See identical proteins and their annotated locations for NP_001288173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.2, also known as variant 8) contains an alternate, in-frame exon in the 5' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.2st, which has a distinct N-terminus, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AY640414, CD679271, CN423297
    Consensus CDS
    CCDS86459.1
    UniProtKB/Swiss-Prot
    P09493
    Related
    ENSP00000453955.2, ENST00000561266.6
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  9. NM_001301289.2 → NP_001288218.1  tropomyosin alpha-1 chain isoform Tpm1.8cy

    See identical proteins and their annotated locations for NP_001288218.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.8, also known as variant 9) contains alternate in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.8cy, which has distinct N- and C-termini and is shorter than isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC079328
    UniProtKB/TrEMBL
    B7Z722
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin

  10. NM_001330344.2 → NP_001317273.1  tropomyosin alpha-1 chain isoform Tpm1.9cy

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.9, also known as variant 10) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.9cy, which has distinct N- and C-termini, compared to isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC079328, AL050179, AL558518
    Consensus CDS
    CCDS81892.1
    UniProtKB/TrEMBL
    H7BYY1
    Related
    ENSP00000384315.4, ENST00000404484.9
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin

  11. NM_001330346.2 → NP_001317275.1  tropomyosin alpha-1 chain isoform Tpm1.13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Tpm1.13, also known as variant 11) has a different 5' structure compared to variant Tpm1.1. It encodes isoform Tpm1.13, which has a distinct N-terminus, compared to isoform Tpm1.1st. Variants Tpm1.8, Tpm1.9 and Tpm1.13 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AC079328, BC007433
    Consensus CDS
    CCDS81894.1
    UniProtKB/TrEMBL
    H0YK48
    Related
    ENSP00000452658.1, ENST00000559281.6
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin

  12. NM_001330351.2 → NP_001317280.1  tropomyosin alpha-1 chain isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform 12, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
    Source sequence(s)
    AC079328, AL050179
    Consensus CDS
    CCDS81891.1
    UniProtKB/TrEMBL
    F5H7S3, Q1ZYL5
    Related
    ENSP00000322577.7, ENST00000317516.12
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 244
    Tropomyosin

  13. NM_001365776.1 → NP_001352705.1  tropomyosin alpha-1 chain isoform Tpm1.10br

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Related
    ENST00000651344.1
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 280
    Tropomyosin

  14. NM_001365777.1 → NP_001352706.1  tropomyosin alpha-1 chain isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Conserved Domains (2) summary
    pfam00261
    Location:48 → 259
    Tropomyosin
    pfam16526
    Location:13 → 72
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

  15. NM_001365778.1 → NP_001352707.1  tropomyosin alpha-1 chain isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC079328, AK131384
    Consensus CDS
    CCDS92009.1
    UniProtKB/TrEMBL
    Q6ZN40
    Related
    ENSP00000350667.4, ENST00000357980.9
    Conserved Domains (2) summary
    TIGR00998
    Location:1 → 159
    8a0101; efflux pump membrane protein (multidrug resistance protein A)
    pfam00261
    Location:90 → 324
    Tropomyosin

  16. NM_001365779.1 → NP_001352708.1  tropomyosin alpha-1 chain isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC079328, M19714
    Consensus CDS
    CCDS92010.1
    UniProtKB/TrEMBL
    A0A0S2Z4G6, A0AAQ5BH79, H0YL52
    Related
    ENSP00000453062.2, ENST00000560970.6
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin; Tropomyosin

  17. NM_001365780.1 → NP_001352709.1  tropomyosin alpha-1 chain isoform Tpm1.11br

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Consensus CDS
    CCDS92013.1
    UniProtKB/TrEMBL
    A0A494BZZ2
    Related
    ENSP00000498284.1, ENST00000651590.1
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 223
    Tropomyosin

  18. NM_001365781.2 → NP_001352710.1  tropomyosin alpha-1 chain isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC079328
    UniProtKB/TrEMBL
    Q1ZYL5
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin

  19. NM_001365782.1 → NP_001352711.1  tropomyosin alpha-1 chain isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Consensus CDS
    CCDS92012.1
    UniProtKB/TrEMBL
    A0A494C0I0, H0YKJ4
    Related
    ENSP00000452830.2, ENST00000558910.3
    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin; Tropomyosin

  20. NM_001407322.1 → NP_001394251.1  tropomyosin alpha-1 chain isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC079328

  21. NM_001407323.1 → NP_001394252.1  tropomyosin alpha-1 chain isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC079328

  22. NM_001407324.1 → NP_001394253.1  tropomyosin alpha-1 chain isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Related
    ENSP00000519303.1, ENST00000714013.1

  23. NM_001407325.1 → NP_001394254.1  tropomyosin alpha-1 chain isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Related
    ENST00000560131.2

  24. NM_001407326.1 → NP_001394255.1  tropomyosin alpha-1 chain isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC079328

  25. NM_001407327.1 → NP_001394256.1  tropomyosin alpha-1 chain isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC079328

  26. NM_001407328.1 → NP_001394257.1  tropomyosin alpha-1 chain isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC079328

  27. NM_001407329.1 → NP_001394258.1  tropomyosin alpha-1 chain isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC079328

  28. NM_001407330.1 → NP_001394259.1  tropomyosin alpha-1 chain isoform Tpm1.5cy

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Consensus CDS
    CCDS10181.1
    UniProtKB/TrEMBL
    A0A0K0K1I0

  29. NM_001407331.1 → NP_001394260.1  tropomyosin alpha-1 chain isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC079328

  30. NM_001407332.1 → NP_001394261.1  tropomyosin alpha-1 chain isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC079328

  31. NM_001407333.1 → NP_001394262.1  tropomyosin alpha-1 chain isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC079328
    UniProtKB/TrEMBL
    A0A0S2Z4G6, H0YL52

  32. NM_001407334.1 → NP_001394263.1  tropomyosin alpha-1 chain isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC079328

  33. NM_001407335.1 → NP_001394264.1  tropomyosin alpha-1 chain isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC079328

  34. NM_001407336.1 → NP_001394265.1  tropomyosin alpha-1 chain isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC079328

  35. NM_001407337.1 → NP_001394266.1  tropomyosin alpha-1 chain isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC079328

  36. NM_001407338.1 → NP_001394267.1  tropomyosin alpha-1 chain isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC079328

  37. NM_001407340.1 → NP_001394269.1  tropomyosin alpha-1 chain isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Consensus CDS
    CCDS92011.1
    UniProtKB/TrEMBL
    B7Z596
    Related
    ENSP00000453724.1, ENST00000560959.5

  38. NM_001407341.1 → NP_001394270.1  tropomyosin alpha-1 chain isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC079328

  39. NM_001407342.1 → NP_001394271.1  tropomyosin alpha-1 chain isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC079328

  40. NM_001407344.1 → NP_001394273.1  tropomyosin alpha-1 chain isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC079328

RNA

  1. NR_176337.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Related
    ENST00000558347.5

  2. NR_176338.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Related
    ENST00000559831.6

  3. NR_176339.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

  4. NR_176340.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

  5. NR_176341.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

  6. NR_176342.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

  7. NR_176343.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

  8. NR_176344.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

  9. NR_176345.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Related
    ENST00000714016.1

  10. NR_176346.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

  11. NR_176347.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

  12. NR_176348.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Related
    ENST00000644204.1

  13. NR_176349.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

  14. NR_176350.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Related
    ENST00000558544.5

  15. NR_176351.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

  16. NR_176352.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328

  17. NR_176353.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079328
    Related
    ENST00000705544.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    63042747..63071915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433001.1 → XP_047288957.1  tropomyosin alpha-1 chain isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    60846575..60875760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378740.1 → XP_054234715.1  tropomyosin alpha-1 chain isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09493.2 GenPept UniProtKB/Swiss-Prot:P09493

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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