TP53 tumor protein p53 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: TP53provided by VGNC
Official Full Name: tumor protein p53provided by VGNC
Primary source: VGNC:VGNC:78627
Locus tag: EGK_08142
See related: Ensembl:ENSMMUG00000008639
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	16	NC_041769.1 (7447315..7466507, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	16	NC_027908.1 (7652077..7670934, complement)

Chromosome 16 - NC_041769.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Non-human primate papillomavirus E6-mediated p53 degradation reveals ancient evolutionary adaptation of carcinogenic phenotype to host niche.
Title: Non-human primate papillomavirus E6-mediated p53 degradation reveals ancient evolutionary adaptation of carcinogenic phenotype to host niche.

Submit: New GeneRIF Correction

General gene information

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Markers

GDB:604633 (e-PCR)
- UniSTS:158212

PMC105081P1 (e-PCR)
- UniSTS:270116

GDB:177797 (e-PCR)
- UniSTS:154963

GDB:177814 (e-PCR)
- UniSTS:154969

GDB:227151 (e-PCR)
- UniSTS:156250

GDB:186560 (e-PCR)
- UniSTS:155496

GDB:363686 (e-PCR)
- UniSTS:156783

GDB:363689 (e-PCR)
- UniSTS:156784

GDB:363692 (e-PCR)
- UniSTS:156785

GDB:363698 (e-PCR)
- UniSTS:156787

GDB:363704 (e-PCR)
- UniSTS:156789

GDB:363724 (e-PCR)
- UniSTS:156790

GDB:363795 (e-PCR)
- UniSTS:156792

GDB:186921 (e-PCR)
- UniSTS:155522

GDB:178567 (e-PCR)
- UniSTS:155019

D17S1506E (e-PCR)
- UniSTS:151711

GDB:316876 (e-PCR)
- UniSTS:156580

PMC135765P1 (e-PCR)
- UniSTS:270771

PMC135765P2 (e-PCR)
- UniSTS:270772

PMC22021P1 (e-PCR)
- UniSTS:272087

PMC22021P2 (e-PCR)
- UniSTS:272088

GDB:190076 (e-PCR)
- UniSTS:155620

PMC156059P1 (e-PCR)
- UniSTS:271356

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cellular tumor antigen p53

Names: P53; tumor suppressor p53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047151.2 → NP_001040616.1 cellular tumor antigen p53

See identical proteins and their annotated locations for NP_001040616.1

Status: PROVISIONAL

Source sequence(s)

L20442

UniProtKB/Swiss-Prot

P56424

UniProtKB/TrEMBL

A0A1I7Q490, A0A8J8XH32, E3U906, G7NIG9

Related

ENSMMUP00000011334.3, ENSMMUT00000012081.4

Conserved Domains (4) summary

cd08367
Location:109 → 289

P53; P53 DNA-binding domain

pfam18521
Location:35 → 59

TAD2; Transactivation domain 2

pfam07710
Location:319 → 355

P53_tetramer; P53 tetramerisation motif

pfam08563
Location:6 → 30

P53_TAD; P53 transactivation motif

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041769.1 Reference Mmul_10 Primary Assembly

Range

7447315..7466507 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028835713.1 → XP_028691546.1 cellular tumor antigen p53 isoform X1

UniProtKB/Swiss-Prot

P56424

UniProtKB/TrEMBL

A0A1I7Q490, A0A8J8XH32, E3U906, G7NIG9

Conserved Domains (4) summary

cd08367
Location:109 → 289

P53; P53 DNA-binding domain

pfam18521
Location:35 → 59

TAD2; Transactivation domain 2

pfam07710
Location:319 → 355

P53_tetramer; P53 tetramerisation motif

pfam08563
Location:6 → 30

P53_TAD; P53 transactivation motif