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TNFAIP2 TNF alpha induced protein 2 [ Homo sapiens (human) ]

Gene ID: 7127, updated on 3-Nov-2024

Summary

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Official Symbol
TNFAIP2provided by HGNC
Official Full Name
TNF alpha induced protein 2provided by HGNC
Primary source
HGNC:HGNC:11895
See related
Ensembl:ENSG00000185215 MIM:603300; AllianceGenome:HGNC:11895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B94; EXOC3L3
Summary
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in urinary bladder (RPKM 54.5), spleen (RPKM 53.6) and 22 other tissues See more
Orthologs
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Genomic context

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See TNFAIP2 in Genome Data Viewer
Location:
14q32.32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103121469..103137439)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97357363..97373355)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103589798..103603776)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene LBH domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103559931-103560500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103561071-103561640 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103564684-103564853 Neighboring gene exocyst complex component 3 like 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103570895-103571645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103576032-103576642 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103576643-103577253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103588729-103589261 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103589262-103589795 Neighboring gene long intergenic non-protein coding RNA 677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103594547-103595312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103598606-103599176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103599177-103599745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103601649-103602150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9098 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 11 Neighboring gene ribosomal protein L21 pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TNFAIP2 Inhibits Early TNFα-Induced NF-x03BA;B Signaling and Decreases Survival in Septic Shock Patients. Thair SA, et al. J Innate Immun, 2016. PMID 26347487, Free PMC Article
  2. Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. Sarma V, et al. J Immunol, 1992 May 15. PMID 1374453
  3. Identification of B94 (TNFAIP2) as a potential retinoic acid target gene in acute promyelocytic leukemia. Rusiniak ME, et al. Cancer Res, 2000 Apr 1. PMID 10766166
  4. A novel role for TNFAIP2: its correlation with invasion and metastasis in nasopharyngeal carcinoma. Chen LC, et al. Mod Pathol, 2011 Feb. PMID 21057457
  5. Aberrant expression of the dendritic cell marker TNFAIP2 by the malignant cells of Hodgkin lymphoma and primary mediastinal large B-cell lymphoma distinguishes these tumor types from morphologically and phenotypically similar lymphomas. Kondratiev S, et al. Am J Surg Pathol, 2011 Oct. PMID 21921781, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The miR-146b-3p/TNFAIP2 axis regulates cell differentiation in acute myeloid leukaemia.
    Title: The miR-146b-3p/TNFAIP2 axis regulates cell differentiation in acute myeloid leukaemia.
  2. TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling.
    Title: TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling.
  3. Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia.
    Title: Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia.
  4. STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease.
    Title: STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease.
  5. M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms.
    Title: M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms.
  6. Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China.
    Title: Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China.
  7. Knockdown of TNFAIP2 resulted in upregulation of E-cadherin expression and downregulation of TWIST1 expression, which decreased motile function in platinum-resistant urothelial cancer cells.
    Title: TNFAIP2 expression induces epithelial-to-mesenchymal transition and confers platinum resistance in urothelial cancer cells.
  8. we establish TNFAIP2 as a novel target of uORF-mediated translational regulation. Furthermore, our findings suggest that during macrophage differentiation a major uORF-dependent translational switch occurs.
    Title: Translation of TNFAIP2 is tightly controlled by upstream open reading frames.
  9. ERp29-MSec interaction appeared to require the presence of other bridging protein(s), perhaps triggered by post-translational modification of ERp29
    Title: The chaperone ERp29 is required for tunneling nanotube formation by stabilizing MSec.
  10. The expression of TNFAIP2 is frequently abnormal in human cancers and in infectious diseases. Due to its significant functions in cell proliferation, angiogenesis, migration and invasion, TNFAIP2 could be a potential diagnostic biomarker and therapeutic target for cancer.
    Title: The roles of TNFAIP2 in cancers and infectious diseases.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in exocyst localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor alpha-induced protein 2
Names
exocyst complex component 3-like 3
primary response gene B94 protein
tumor necrosis factor, alpha induced protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371220.1 → NP_001358149.1  tumor necrosis factor alpha-induced protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL161669
    Related
    ENSP00000452914.2, ENST00000559255.2
    Conserved Domains (1) summary
    pfam06046
    Location:122 → 651
    Sec6; Exocyst complex component Sec6

  2. NM_001371221.1 → NP_001358150.1  tumor necrosis factor alpha-induced protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL161669
    Conserved Domains (1) summary
    pfam06046
    Location:122 → 651
    Sec6; Exocyst complex component Sec6

  3. NM_006291.4 → NP_006282.2  tumor necrosis factor alpha-induced protein 2 isoform 1

    See identical proteins and their annotated locations for NP_006282.2

    Status: REVIEWED

    Source sequence(s)
    AL161669
    Consensus CDS
    CCDS9979.1
    UniProtKB/Swiss-Prot
    Q03169, Q86VI0
    Related
    ENSP00000452634.2, ENST00000560869.6
    Conserved Domains (1) summary
    pfam06046
    Location:122 → 651
    Sec6; Exocyst complex component Sec6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    103121469..103137439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431737.1 → XP_047287693.1  tumor necrosis factor alpha-induced protein 2 isoform X1

  2. XM_011537113.3 → XP_011535415.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011535415.1

    Conserved Domains (1) summary
    pfam06046
    Location:122 → 651
    Sec6; Exocyst complex component Sec6

  3. XM_047431736.1 → XP_047287692.1  tumor necrosis factor alpha-induced protein 2 isoform X1

  4. XM_011537112.3 → XP_011535414.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011535414.1

    Conserved Domains (1) summary
    pfam06046
    Location:122 → 651
    Sec6; Exocyst complex component Sec6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    97357363..97373355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376662.1 → XP_054232637.1  tumor necrosis factor alpha-induced protein 2 isoform X1

  2. XM_054376658.1 → XP_054232633.1  tumor necrosis factor alpha-induced protein 2 isoform X1

  3. XM_054376661.1 → XP_054232636.1  tumor necrosis factor alpha-induced protein 2 isoform X1

  4. XM_054376659.1 → XP_054232634.1  tumor necrosis factor alpha-induced protein 2 isoform X1

  5. XM_054376660.1 → XP_054232635.1  tumor necrosis factor alpha-induced protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03169.2 GenPept UniProtKB/Swiss-Prot:Q03169

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