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Rsph14 radial spoke head homolog 14 (Chlamydomonas) [ Mus musculus (house mouse) ]

Gene ID: 71236, updated on 2-Nov-2024

Summary

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Official Symbol
Rsph14provided by MGI
Official Full Name
radial spoke head homolog 14 (Chlamydomonas)provided by MGI
Primary source
MGI:MGI:1918486
See related
Ensembl:ENSMUSG00000009070 AllianceGenome:MGI:1918486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rtdr1; 4933431K05Rik
Summary
Predicted to be involved in epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and mating. Part of radial spoke. Is expressed in lung epithelium and nasal cavity respiratory epithelium. Orthologous to human RSPH14 (radial spoke head 14 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 5.7), ovary adult (RPKM 0.8) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Rsph14 in Genome Data Viewer
Location:
10 B5.3; 10 38.48 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (74793309..74868475, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (74957477..75032642, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene 6419 Neighboring gene STARR-seq mESC enhancer starr_27145 Neighboring gene guanine nucleotide binding protein, alpha z subunit Neighboring gene predicted gene, 40692 Neighboring gene RAB36, member RAS oncogene family Neighboring gene BCR activator of RhoGEF and GTPase Neighboring gene STARR-positive B cell enhancer ABC_E10622 Neighboring gene STARR-positive B cell enhancer mm9_chr10:74614065-74614365

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential requirements of IQUB for the assembly of radial spoke 1 and the motility of mouse cilia and flagella. Zhang X, et al. Cell Rep, 2022 Nov 22. PMID 36417862
  2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  3. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in epithelial cilium movement involved in extracellular fluid movement IC
Inferred by Curator
more info
 PubMed 
involved_in flagellated sperm motility IC
Inferred by Curator
more info
 PubMed 
involved_in mating IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in 9+2 motile cilium IC
Inferred by Curator
more info
 PubMed 
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of radial spoke IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
radial spoke head 14 homolog
Names
rhabdoid tumor deletion region gene 1
rhabdoid tumor deletion region protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163533.1 → NP_001157005.1  radial spoke head 14 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC142500, AK017008, BB616907
    Consensus CDS
    CCDS48597.1
    UniProtKB/TrEMBL
    E9PWZ8
    Related
    ENSMUSP00000131632.2, ENSMUST00000166088.8
    Conserved Domains (4) summary
    cd00020
    Location:257 → 370
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam13646
    Location:184 → 287
    HEAT_2; HEAT repeats
    sd00044
    Location:184 → 208
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:223 → 248
    ARM; armadillo repeat [structural motif]

  2. NM_001163534.1 → NP_001157006.1  radial spoke head 14 homolog isoform 3

    See identical proteins and their annotated locations for NP_001157006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' exon, which results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK017008, BB616907, BC147801
    Consensus CDS
    CCDS48596.1
    UniProtKB/Swiss-Prot
    Q9D3W1
    Related
    ENSMUSP00000136715.2, ENSMUST00000179546.8
    Conserved Domains (4) summary
    cd00020
    Location:224 → 337
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam13646
    Location:151 → 254
    HEAT_2; HEAT repeats
    sd00044
    Location:151 → 175
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:190 → 215
    ARM; armadillo repeat [structural motif]

  3. NM_001163535.1 → NP_001157007.1  radial spoke head 14 homolog isoform 3

    See identical proteins and their annotated locations for NP_001157007.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites in the 5' region, which result in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK017008, BC147792, BY716693
    Consensus CDS
    CCDS48596.1
    UniProtKB/Swiss-Prot
    Q9D3W1
    Related
    ENSMUSP00000009214.4, ENSMUST00000009214.10
    Conserved Domains (4) summary
    cd00020
    Location:224 → 337
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam13646
    Location:151 → 254
    HEAT_2; HEAT repeats
    sd00044
    Location:151 → 175
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:190 → 215
    ARM; armadillo repeat [structural motif]

  4. NM_027730.1 → NP_082006.1  radial spoke head 14 homolog isoform 2

    See identical proteins and their annotated locations for NP_082006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AK017008, BB616907
    UniProtKB/Swiss-Prot
    Q9D3W1
    Conserved Domains (4) summary
    cd00020
    Location:256 → 369
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam13646
    Location:183 → 286
    HEAT_2; HEAT repeats
    sd00044
    Location:183 → 207
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:222 → 247
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    74793309..74868475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514117.5 → XP_006514180.1  radial spoke head 14 homolog isoform X1

    Conserved Domains (3) summary
    sd00044
    Location:102 → 126
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:177 → 208
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:253 → 286
    Arm; Armadillo/beta-catenin-like repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3W1.1 GenPept UniProtKB/Swiss-Prot:Q9D3W1

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