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PRDX2 peroxiredoxin 2 [ Homo sapiens (human) ]

Gene ID: 7001, updated on 3-Nov-2024

Summary

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Official Symbol
PRDX2provided by HGNC
Official Full Name
peroxiredoxin 2provided by HGNC
Primary source
HGNC:HGNC:9353
See related
Ensembl:ENSG00000167815 MIM:600538; AllianceGenome:HGNC:9353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a
Summary
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
Expression
Ubiquitous expression in bone marrow (RPKM 201.9), heart (RPKM 194.1) and 25 other tissues See more
Orthologs
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Genomic context

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See PRDX2 in Genome Data Viewer
Location:
19p13.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12796823..12801800, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12921315..12926305, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12907637..12912614, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene hook microtubule tethering protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14079 Neighboring gene CRISPRi-FlowFISH-validated JUNB regulatory element Neighboring gene microRNA 5684 Neighboring gene CRISPRi-FlowFISH-validated PRDX2 regulatory element 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10173 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12904163-12904664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14082 Neighboring gene JunB proto-oncogene, AP-1 transcription factor subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14083 Neighboring gene CRISPRi-FlowFISH-validated RNASEH2A regulatory element Neighboring gene CRISPRi-FlowFISH-validated PRDX2 regulatory element 4 Neighboring gene thrombospondin type 1 domain containing 8 Neighboring gene ribonuclease H2 subunit A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human pancreatic cancer cells with acquired gemcitabine resistance exhibit significant up-regulation of peroxiredoxin-2 compared to sensitive parental cells. Suenaga S, et al. Anticancer Res, 2013 Nov. PMID 24222118
  2. The malarial parasite Plasmodium falciparum imports the human protein peroxiredoxin 2 for peroxide detoxification. Koncarevic S, et al. Proc Natl Acad Sci U S A, 2009 Aug 11. PMID 19666612, Free PMC Article
  3. Prx2 links ROS homeostasis to stemness of cancer stem cells. Son YW, et al. Free Radic Biol Med, 2019 Apr. PMID 30611866
  4. Overexpression of peroxiredoxin 2 in pterygium. A proteomic approach. Bautista-de Lucio VM, et al. Exp Eye Res, 2013 May. PMID 23499777
  5. Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2. Peskin AV, et al. J Biol Chem, 2021 Jan-Jun. PMID 33667550, Free PMC Article

See all (346) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of PRDX2 Inhibits the Proliferation, Growth, Migration, Invasion, and MMP9 Activity of Ewing's Sarcoma Cells Cultured In Vitro.
    Title: Knockdown of PRDX2 Inhibits the Proliferation, Growth, Migration, Invasion, and MMP9 Activity of Ewing's Sarcoma Cells Cultured In Vitro.
  2. PRDX2 regulates stemness contributing to cisplatin resistance and metastasis in bladder cancer.
    Title: PRDX2 regulates stemness contributing to cisplatin resistance and metastasis in bladder cancer.
  3. Implications and progression of peroxiredoxin 2 (PRDX2) in various human diseases.
    Title: Implications and progression of peroxiredoxin 2 (PRDX2) in various human diseases.
  4. MiR-92a-2-5p suppresses esophageal squamous cell carcinoma cell proliferation and invasion by targeting PRDX2.
    Title: MiR-92a-2-5p suppresses esophageal squamous cell carcinoma cell proliferation and invasion by targeting PRDX2.
  5. Silencing of peroxiredoxin 2 suppresses proliferation and Wnt/beta-catenin pathway, and induces senescence in hepatocellular carcinoma.
    Title: Silencing of peroxiredoxin 2 suppresses proliferation and Wnt/β-catenin pathway, and induces senescence in hepatocellular carcinoma.
  6. Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells.
    Title: Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells.
  7. Negative pressure wound therapy promotes wound healing of diabetic foot ulcers by up-regulating PRDX2 in wound margin tissue.
    Title: Negative pressure wound therapy promotes wound healing of diabetic foot ulcers by up-regulating PRDX2 in wound margin tissue.
  8. The Study of Overexpression of Peroxiredoxin-2 Reduces MPP[+]-Induced Toxicity in the Cell Model of Parkinson's Disease.
    Title: The Study of Overexpression of Peroxiredoxin-2 Reduces MPP(+)-Induced Toxicity in the Cell Model of Parkinson's Disease.
  9. Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway.
    Title: Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway.
  10. ANXA2, SP17, SERPINA5, PRDX2 genes, and sperm DNA fragmentation differentially represented in male partners of infertile couples with normal and abnormal sperm parameters.
    Title: ANXA2, SP17, SERPINA5, PRDX2 genes, and sperm DNA fragmentation differentially represented in male partners of infertile couples with normal and abnormal sperm parameters.
Submit: New GeneRIF Correction See all GeneRIFs (160)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human peroxiredoxin 2 (PRDX2) at amino acid residues 47-48 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC4104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antioxidant activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables antioxidant activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin peroxidase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to tumor cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in leukocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of hydrogen peroxide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in removal of superoxide radicals IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in respiratory burst involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in thymus development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
peroxiredoxin-2
Names
epididymis secretory sperm binding protein Li 2a
natural killer cell-enhancing factor B
thiol-specific antioxidant 1
thioredoxin peroxidase 1
thioredoxin-dependent peroxide reductase 1
thioredoxin-dependent peroxiredoxin 2
torin
NP_005800.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029901.1 RefSeqGene

    Range
    5081..10058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005809.6 → NP_005800.3  peroxiredoxin-2

    See identical proteins and their annotated locations for NP_005800.3

    Status: REVIEWED

    Source sequence(s)
    BC000452, BP248561
    Consensus CDS
    CCDS12281.1
    UniProtKB/Swiss-Prot
    A8K0C0, P31945, P32118, P32119, P35701, Q6FHG4, Q92763, Q9UC23
    UniProtKB/TrEMBL
    V9HW12
    Related
    ENSP00000301522.2, ENST00000301522.3
    Conserved Domains (1) summary
    cd03015
    Location:8 → 179
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12796823..12801800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12921315..12926305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181737.1: Suppressed sequence

    Description
    NM_181737.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_181738.1: Suppressed sequence

    Description
    NM_181738.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32119.5 GenPept UniProtKB/Swiss-Prot:P32119

Gene LinkOut

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