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Cdc16 CDC16 cell division cycle 16 [ Mus musculus (house mouse) ]

Gene ID: 69957, updated on 2-Nov-2024

Summary

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Official Symbol
Cdc16provided by MGI
Official Full Name
CDC16 cell division cycle 16provided by MGI
Primary source
MGI:MGI:1917207
See related
Ensembl:ENSMUSG00000038416 AllianceGenome:MGI:1917207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APC6; 2700071J12Rik; 2810431D22Rik
Summary
Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Located in nucleus. Is expressed in brain; cerebellum; and cerebral cortex. Orthologous to human CDC16 (cell division cycle 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 32.5), CNS E11.5 (RPKM 27.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cdc16 in Genome Data Viewer
Location:
8 A1.1; 8 6.38 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13807650..13831951)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13757649..13781951)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46032 Neighboring gene CFAP97 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_20774 Neighboring gene STARR-seq mESC enhancer starr_20775 Neighboring gene STARR-positive B cell enhancer mm9_chr8:13753700-13754000 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene UPF3 regulator of nonsense transcripts homolog A (yeast) Neighboring gene SUMO/sentrin specific peptidase 2-like 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Fan M, et al. Genes Dev, 2004 Feb 1. PMID 14744933, Free PMC Article
  2. An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance. Li N, et al. Oncogenesis, 2019 Feb 19. PMID 30783098, Free PMC Article
  3. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Ferguson CJ, et al. Mol Cell, 2022 Jan 6. PMID 34942119, Free PMC Article
  4. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
  5. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein branched polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
part_of anaphase-promoting complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell division cycle protein 16 homolog
Names
anaphase-promoting complex subunit 6
cyclosome subunit 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357247.1 → NP_001344176.1  cell division cycle protein 16 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134623
    Conserved Domains (4) summary
    COG3063
    Location:277 → 417
    PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
    TIGR02917
    Location:135 → 414
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:353 → 379
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:353 → 417
    TPR_12; Tetratricopeptide repeat

  2. NM_027276.3 → NP_081552.2  cell division cycle protein 16 homolog isoform 1

    See identical proteins and their annotated locations for NP_081552.2

    Status: VALIDATED

    Source sequence(s)
    AC134623, AK147938
    Consensus CDS
    CCDS22114.1
    UniProtKB/Swiss-Prot
    Q8R349, Q9CYX9
    UniProtKB/TrEMBL
    Q3TI84
    Related
    ENSMUSP00000047950.9, ENSMUST00000043962.9
    Conserved Domains (4) summary
    smart00028
    Location:448 → 478
    TPR; Tetratricopeptide repeats
    sd00006
    Location:447 → 473
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:15 → 94
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13414
    Location:447 → 509
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13807650..13831951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154276.1 → XP_036010169.1  cell division cycle protein 16 homolog isoform X2

    Conserved Domains (3) summary
    COG3063
    Location:65 → 205
    PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
    sd00006
    Location:141 → 167
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:141 → 205
    TPR_12; Tetratricopeptide repeat

  2. XM_006508882.4 → XP_006508945.1  cell division cycle protein 16 homolog isoform X1

    See identical proteins and their annotated locations for XP_006508945.1

    Conserved Domains (4) summary
    COG3063
    Location:277 → 417
    PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
    TIGR02917
    Location:135 → 414
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:353 → 379
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:353 → 417
    TPR_12; Tetratricopeptide repeat

  3. XM_036154277.1 → XP_036010170.1  cell division cycle protein 16 homolog isoform X2

    Conserved Domains (3) summary
    COG3063
    Location:65 → 205
    PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
    sd00006
    Location:141 → 167
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:141 → 205
    TPR_12; Tetratricopeptide repeat

RNA

  1. XR_004934874.1 RNA Sequence

  2. XR_004934875.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R349.1 GenPept UniProtKB/Swiss-Prot:Q8R349

Gene LinkOut

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