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LIAS lipoic acid synthetase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 699244, updated on 5-Mar-2024

Summary

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Official Symbol
LIASprovided by VGNC
Official Full Name
lipoic acid synthetaseprovided by VGNC
Primary source
VGNC:VGNC:74057
Locus tag
EGK_15657
See related
Ensembl:ENSMMUG00000013851
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See LIAS in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (38579655..38598572)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (39089718..39108382)

Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene klotho beta Neighboring gene ribosomal protein L9 Neighboring gene WD repeat-containing protein 5 pseudogene Neighboring gene UDP-glucose 6-dehydrogenase Neighboring gene uncharacterized LOC114678106

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipoate synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipoate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lipoyl synthase, mitochondrial
NP_001248031.1
XP_028703846.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261102.1 → NP_001248031.1  lipoyl synthase, mitochondrial

    See identical proteins and their annotated locations for NP_001248031.1

    Status: PROVISIONAL

    Source sequence(s)
    JU321514
    UniProtKB/TrEMBL
    A0A1D5QS99, A0A8J8XVD6, F6RMC6, G7MSS0
    Related
    ENSMMUP00000018203.2, ENSMMUT00000019439.4
    Conserved Domains (3) summary
    cd01335
    Location:134 → 330
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    PLN02428
    Location:22 → 371
    PLN02428; lipoic acid synthase
    pfam16881
    Location:15 → 111
    LIAS_N; N-terminal domain of lipoyl synthase of Radical_SAM family

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041758.1 Reference Mmul_10 Primary Assembly

    Range
    38579655..38598572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028848013.1 → XP_028703846.1  lipoyl synthase, mitochondrial isoform X1

    Conserved Domains (2) summary
    PLN02428
    Location:101 → 268
    PLN02428; lipoic acid synthase
    pfam16881
    Location:15 → 78
    LIAS_N; N-terminal domain of lipoyl synthase of Radical_SAM family
Nucleotide Protein
Heading Accession and Version

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