TRBV20OR9-2 T cell receptor beta variable 20/OR9-2 (non-functional) [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRBV20OR9-2provided by HGNC
Official Full Name: T cell receptor beta variable 20/OR9-2 (non-functional)provided by HGNC
Primary source: HGNC:HGNC:12197
See related: Ensembl:ENSG00000205274 IMGT/GENE-DB:TRBV20/OR9-2; AllianceGenome:HGNC:12197
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TCR; TRB; CDR3; TCRB; TCRBV2O; TCRBV20S2; TCRBV2S2O
Summary: Predicted to be involved in cell surface receptor signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 9p13.3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (33617845..33618508)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (33636357..33637020)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (33617843..33618506)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modifications outside CDR1, 2 and 3 of the TCR variable beta domain increase TCR expression and antigen-specific function.
Title: Modifications outside CDR1, 2 and 3 of the TCR variable β domain increase TCR expression and antigen-specific function.
Circulating tumor DNA by high-throughput sequencing of T cell receptor monitored treatment response and predicted treatment failure in T cell lymphomas.
Title: Circulating tumor DNA by high-throughput sequencing of T cell receptor monitored treatment response and predicted treatment failure in T cell lymphomas.
Intra-tumoral T cell receptor beta (TCR beta) repertoires were spatially homogeneous between different regions of a single tumor tissue.
Title: T cell receptor β-chain repertoire analysis of tumor-infiltrating lymphocytes in pancreatic cancer.
Authors failed to detect a subset with an abnormally long CDR3 repertoire, as would be predicted by a failure in selection.
Title: A normal T cell receptor beta CDR3 length distribution in patients with APECED.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Other Names

T cell receptor beta chain
T cell receptor beta variable 20/OR9-2 pseudogene
T-cell receptor beta chain variable region
T-cell receptor, beta variable region 2, orphon
TRBV20/OR9-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.